Abstract：
:There is growing evidence that Mangiferin possess therapeutic benefit during neuroinflammation on various brain injury models due to its anti-inflammatory properties. It is reported that inflammatory plays a crucial role in the pathogenesis of secondary injury induced by the blast-induced traumatic brain injury (bTBI). However, the role of mangiferin in bTBI is yet to be studied. In our study, the potential effect of mangiferin in the duration of bTBI was examined first. Fortunately, the amelioration of cerebral cortex damage was found in rats suffering bTBI after mangiferin administration. Furthermore, the detail mechanism of mangiferin's beneficial actions in bTBI was also studied. The results revealed that mangiferin might alleviate brain damage in rats with bTBI by inhibiting the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome activation, which was accompanied by mangiferin's inhibition of oxidative stress and pro-inflammatory cytokines production. Therefore, this research allows us to speculate that, for first time, NLRP3 is involved in the anti-inflammatory effect of mangiferin in the cerebral cortex, and mangiferin could be a potential therapy drug for bTBI.
journal_name
Chem Biol Interactjournal_title
Chemico-biological interactionsauthors
Fan K,Ma J,Xiao W,Chen J,Wu J,Ren J,Hou J,Hu Y,Gu J,Yu Bdoi
10.1016/j.cbi.2017.04.021subject
Has Abstractpub_date
2017-06-01 00:00:00pages
15-23eissn
0009-2797issn
1872-7786pii
S0009-2797(17)30156-4journal_volume
271pub_type
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