Strong association between cardiorespiratory fitness and serum lipoprotein subclass pattern in prepubertal healthy children.

Abstract:

:This study reveals the lipoprotein subclass pattern associated with cardiorespiratory fitness (CRF) in healthy children. Serum concentrations of lipoprotein subclasses and concentrations and average particle size of their main classes were quantified in 94 ethnic Norwegian children using high-performance liquid chromatography (HPLC). Twenty-four lipoprotein features were used as input to multivariate regression analysis with CRF measured either by peak oxygen consumption (VO2peak) using a continuous treadmill protocol or indirectly by the 10-minute Andersen intermittent running field test. By including BMI and gender as descriptors, a predictive cross-validated multivariate regression model was obtained for both CRF measures. CRF correlated positively with average particle size for high-density lipoprotein (HDL) and its subclasses of large HDL particles and negatively with very small HDL particles, chylomicrons, triglycerides, and average size and concentration of very low-density lipoprotein (VLDL) particles and VLDL subclasses of large particles (P<.05). BMI correlated negatively with both measures of CRF, but exhibited a stronger association with VO2peak than with the Andersen test. Our data showed a strong association between CRF measured either by VO2peak or by the Andersen test and a subclass lipoprotein pattern that is associated with cardiovascular (CV) health. Thus, our results show why high levels of CRF are beneficial for children's CV health. The Andersen test, being a practical field test that involves minimal equipment and, being less influenced by BMI than VO2peak, represents a good measure of CRF, and, accordingly, a proxy measure of cardiovascular health status in children.

journal_name

Scand J Med Sci Sports

authors

Resaland GK,Rajalahti T,Aadland E,Kvalheim OM

doi

10.1111/sms.12897

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

220-227

issue

1

eissn

0905-7188

issn

1600-0838

journal_volume

28

pub_type

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