Concomitant thyroid cancer in patients with primary hyperparathyroidism in an endemic goitre region.

Abstract:

OBJECTIVE:Primary hyperparathyroidism (pHPT) is often accompanied by underlying thyroid pathology and 1 to 36% of these thyroid pathologies are malignant. How the identification of these lesions affects patient management is unclear. We present a single-center experience with the prevalence of concomitant thyroid cancer in patients who underwent parathyroidectomy for pHPT. MATERIALS AND METHODS:This was a retrospective cohort study. Two hundred-two patients with primary hyperparathyroidism included study. Demographic data, clinical findings, and final histopathological diagnosis were recorded retrospectively. RESULTS:Preoperative cervical ultrasound examination revealed co-existent thyroid abnormalities in 117 (57.9%) patients. Mean age of these patients was 57.8 ± 12.2 years and 88% were female. Sixty-three (53.9%) of the patients with thyroid abnormalities, underwent preoperative fine needle aspiration biopsy (FNAB). Cytology result was malignant in one (1.6%) patient, benign in 47(85.7%) patients, indeterminate in six (9.5%) patients and Hurthle cell neoplasm in two (3.2%) patients. Ninety-four (80.3%) of the patients underwent simultaneous thyroid surgery. Final pathology of the thyroid specimen was malignant in 26 (12.9%) patients. Sixteen of the malignant patients had preoperative FNAB. Preoperative FNAB result of these patients was malignant in one patient, indeterminate in two patients and benign in 13 patients. CONCLUSION:By implementing a comprehensive approach to patients with pHPT who present with thyroid disease, concomitant pathology may be elucidated preoperatively. But, this approach will not facilitate the detection of otherwise unsuspected thyroid cancer in an endemic goitre region. KEY WORDS:Cancer, Parathyroid adenoma, Parathyroidectomy, Thyroid, Thyroidectomy. :L’iperparatiroidismo primario (pHPT) si accompagna spesso ad una patologia tiroidea concomitante, che da 1 a 36% è di natura maligna. Non è chiaro in che modo l’identificazione di tali patologia influenzino il trattamento dei relativi pazienti. Qui presentiamo l’esperienza di un singolo centro con rilevamento di un concomitante cancro della tiroide in pazienti sottoposti a paratiroidectomia per pHPT. Si tratta di uno studio retrospettivo che include 202 pazienti con iperparatiroidismo primario, con verifica dei dati demografici, dei rilievi clinici e diagnosi istopatologica definitiva, ed in 117 di questi pazienti (57,9&) l’ecografia preoperatoria del collo aveva rilevato la coesistenza di anomalie della tiroide, L’età media di questi pazienti è di 57.8 ± 12.2 anni con 88% di sesso femminile. In 63 dei pazienti con anomalie tiroidee (53,9%) si era proceduto a FNAB, con citologia indicante natura maligna in un caso (1,6%), natura benigna in 47 casi (85,7%) , risultato incerto in 6 pazienti (9%) e 2 casi di carcinoma di Hurthle in 2 pazienti (3.2%). In 94 pazienti (80,3%) alla paratiroidectomia era stata associata chirurgia della tiroide, con riscontro istopatologico di malignità in 26 casi (12,9%) in 16 di cui era stata effettuata la FNAB preoperatoria, con risultato di malignità in un caso, di incertezza in due casi e referto di benignità nei restanti 13 pazienti. Esiste dunque la possibilità di chiarire preoperatoriamente la natura della patologia tiroidea concomitante ad pHPT incrementando opportunamente lo studio pre-intervento, ma questo atteggiamento non varrà a facilitare l’individuazione in una regione di gozzo endemico popolazione di cancri tiroidei non sospettabili per altri motivi.

journal_name

Ann Ital Chir

authors

Simsek B,Guldogan CE,Ozden S,Saylam B,Karabeyoglu SM,Tez M

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

15-19

eissn

0003-469X

issn

2239-253X

pii

S0003469X17026227

journal_volume

88

pub_type

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