Abstract：
:The interactive association of age and dopaminergic polymorphisms on cognitive function has been studied extensively. However, there is limited research on whether age interacts with the association between genetic polymorphisms and motor learning. We examined a group of young and older adults' performance in three motor tasks: explicit sequence learning, visuomotor adaptation, and grooved pegboard. We assessed whether individuals' motor learning and performance were associated with their age and genotypes. We selected three genetic polymorphisms: Catechol-O-Methyl Transferase (COMT val158met) and Dopamine D2 Receptor (DRD2 G>T), which are involved with dopaminergic regulation, and Brain Derived Neurotrophic Factor (BDNF val66met) that modulates neuroplasticity and has been shown to interact with dopaminergic genes. Although the underlying mechanisms of the function of these three genotypes are different, the high performance alleles of each have been linked to better learning and performance. We created a composite polygene score based on the Number of High Performance Alleles (NHPA) that each individual carried. We found several associations between genetic profile, motor performance, and sensorimotor adaptation. More importantly, we found that this association varies with age, task type, and engagement of implicit versus explicit learning processes.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Noohi F,Boyden NB,Kwak Y,Humfleet J,Müller ML,Bohnen NI,Seidler RDdoi
10.1016/j.neuropsychologia.2016.02.021subject
Has Abstractpub_date
2016-04-01 00:00:00pages
222-34eissn
0028-3932issn
1873-3514pii
S0028-3932(16)30047-1journal_volume
84pub_type
杂志文章相关文献
NEUROPSYCHOLOGIA文献大全abstract：:Common polymorphisms in the gene PCSK6, whose protein product mediates the development of brain and body asymmetry through the NODAL pathway, have recently been associated with handedness in three studies, making it a key candidate gene for understanding the developmental and expression of human lateralization. We tes...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2016.02.020
更新日期：2016-04-01 00:00:00
abstract：:The present EEG study investigated the impact of subjective reward preferences and agency on outcome processing. 47 healthy adults (11 male; 36 female) with preferences for either milk or white chocolate completed two runs of a gambling task involving their preferred chocolate (high preference outcomes, HPOs), non-pre...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2019.107139
更新日期：2019-09-01 00:00:00
abstract：:A growing body of literature shows that the emotional content of verbal material affects reading, wherein emotional words are given processing priority compared to neutral words. Human emotions can be conceptualised within a two-dimensional model comprised of emotional valence and arousal (intensity). These variables ...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2014.01.002
更新日期：2014-04-01 00:00:00
abstract：:We report a patient who, following a focal ischemic lesion of the left basal ganglia, developed right hand micrographia characterised by progressive reduction of letter size during writing (progressive micrographia). The patient did not show relevant cognitive impairments, but achieved pathological scores in tests for...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2007.01.002
更新日期：2007-04-09 00:00:00
abstract：:In this study, we attempted to better delineate the changes in corticospinal excitability that accompany perceptual to motor transformations when people are asked to observe, image or imitate actions. Motor evoked potentials (MEP) from transcranial magnetic stimulation were recorded in the first dorsal interosseous (F...
journal_title：Neuropsychologia
pub_type： 临床试验,杂志文章
doi：10.1016/s0028-3932(03)00144-1
更新日期：2004-01-01 00:00:00
abstract：:Studies demonstrating hippocampal activation associated with memories for persons from whom information is acquired (external source monitoring) are lacking. In this study, we used functional magnetic resonance imaging (fMRI) to investigate whether the medial temporal lobe (MTL), especially the hippocampus, is activat...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2010.01.021
更新日期：2010-05-01 00:00:00
abstract：:We investigated the neural basis of newly learned words in Spanish as a mother tongue (L1) and English as a second language (L2). Participants acquired new names for real but unfamiliar concepts in both languages over the course of two days. On day 3, they completed a semantic categorization task during fMRI scanning....
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2020.107703
更新日期：2020-12-09 00:00:00
abstract：:Moorlaas (1928) proposed that apraxic patients can identify objects and can remember the purpose they have been made for but do not know the way in which they must be used to achieve that purpose. Knowledge about the use of objects and tools can have two sources: It can be based on retrieval of instructions of use fro...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/s0028-3932(97)00165-6
更新日期：1998-07-01 00:00:00
abstract：:Directional motion processing is a pervasive and functionally important feature of the visual system. Behavioural and VEP studies indicate that it appears as a cortical function after about 7 weeks of age, with global processing, motion based segmentation, and the use of motion in complex perceptual tasks emerging sho...
journal_title：Neuropsychologia
pub_type： 杂志文章,评审
doi：10.1016/s0028-3932(03)00178-7
更新日期：2003-01-01 00:00:00
abstract：:We conducted a functional magnetic resonance imaging (fMRI) study and a voxel-based morphometry (VBM) study to investigate the functional and structural basis of how visual search for flavor labels in packaging is influenced by the color of the packaging. The participants were cued by a flavor word before searching fo...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2019.02.013
更新日期：2019-04-01 00:00:00
abstract：:Overweight or obesity can be accompanied by abnormalities in executive function and related neural markers. The aim of the present study was to investigate the behavioral and neural correlates of food-related decision-making in overweight and normal-weight adults. We used a delayed discounting task (DDT), which requir...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2019.107181
更新日期：2019-10-01 00:00:00
abstract：:Intraindividual trial-to-trial reaction time (RT) variability is commonly found to be higher in clinical populations or life periods that are associated with impaired cognition. In the present study, higher within-person trial-to-trial RT variability in a perceptual speed task is related to more forgetting and dediffe...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2011.03.013
更新日期：2011-06-01 00:00:00
abstract：:The serial reaction time (SRT) task has been frequently used to assess procedural learning of sequences. Patients with Parkinson's disease (PD) have been reported to show deficits on this task, but it is as yet unclear whether this impairment reflects a general sequencing deficit or a deficit in the sequencing of moto...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/s0028-3932(00)00059-2
更新日期：2000-01-01 00:00:00
abstract：:Heterotopagnosia is the acquired inability of brain-lesioned patients to point at someone else's body parts when prompted. The cognitive basis of this disorder is unclear. It might result from a biological function deficit critical for communication in human beings; alternatively, it could result from the disruption o...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2009.02.016
更新日期：2009-06-01 00:00:00
abstract：:With respect to what frames of reference, or spatial coordinate systems, is attention allocated to locations in space? We posed this question about the spatial attention system that has been damaged in neglect patients, distinguishing among three possible types of spatial reference frame: viewer-centered, according to...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/0028-3932(90)90060-2
更新日期：1990-01-01 00:00:00
abstract：:Prior fMRI studies have reported relationships between memory-related activity in the hippocampus and in-scanner memory performance, but whether such activity is predictive of longitudinal memory change remains unclear. Here, we administered a neuropsychological test battery to a sample of cognitively healthy older ad...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2020.107537
更新日期：2020-09-01 00:00:00
abstract：:Recent research posits that the cognitive system samples target stimuli in a rhythmic fashion, characterized by target detection fluctuating at frequencies of ~3-8 Hz. Besides prioritized encoding of targets, a key cognitive function is the protection of working memory from distractor intrusion. Here, we test to which...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2020.107505
更新日期：2020-09-01 00:00:00
abstract：:In primates fibres from nasal retinae project contralaterally and those from temporal retinae ipsilaterally. At the border between these two regions an area of overlap where ipsi- and contralaterally projecting ganglion cells intermingle has been demonstrated in monkeys and cats. However, behavioural studies have fail...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/0028-3932(84)90011-3
更新日期：1984-01-01 00:00:00
abstract：:The brain activity during a sentence reading task and a visual control task was examined with fMRI in 13 German dyslexic readers and 15 age-matched fluent readers (age: 14-16 years). These participants came from a longitudinal study and the dyslexic readers exhibited a persistent reading fluency deficit from early on....
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2006.03.010
更新日期：2006-01-01 00:00:00
abstract：:An extensive network of cortical areas is involved in multisensory object and action recognition. This network draws on inferior frontal, posterior temporal, and parietal areas; activity is modulated by familiarity and the semantic congruency of auditory and visual component signals even if semantic incongruences are ...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2013.05.014
更新日期：2013-08-01 00:00:00
abstract：:Language tasks used for clinical fMRI studies may be too complex for some patients with cognitive impairments, and "easier" versions are sometimes substituted, though the effects on brain activity of such changes in task complexity are largely unknown. To investigate these differences, we compared two versions of an f...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2015.12.020
更新日期：2016-01-29 00:00:00
abstract：:Affect sharing and prosocial motivation are integral parts of empathy that are conceptually and mechanistically distinct. We used a neurodegenerative disease (NDG) lesion model to examine the neural correlates of these two aspects of real-world empathic responding. The study enrolled 275 participants, including 44 hea...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2017.02.010
更新日期：2018-07-31 00:00:00
abstract：:Consciousness and working memory (WM) have been thought to be closely related, but their exact relationship has remained unclear. The present study focused on the question whether visual awareness, the subjective experience of seeing, depends on resources of WM. Three dual-task experiments were run. The participants w...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2018.10.011
更新日期：2018-11-01 00:00:00
abstract：:Music and language processing share and sometimes compete for brain resources. An extreme case of such shared processing occurs in improvised rap music, in which performers, or 'lyricists', combine rhyming, rhythmic, and semantic structures of language with musical rhythm, harmony, and phrasing to create integrally me...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2019.03.022
更新日期：2019-06-01 00:00:00
abstract：:Although an enhancing effect of reward on cognitive performance has been observed consistently, its neural underpinnings remain elusive. Recent evidence suggests that the inferior frontal junction (IFJ) may be a key player underlying such an enhancement by integrating motivational processes and cognitive control. Howe...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2019.01.016
更新日期：2019-03-04 00:00:00
abstract：:This case study examined phonemic reading and reading comprehension in the presence of Broca's aphasia. The patient, T.B., a 16 yr old male, suffered an occlusion of the middle cerebral artery. Spontaneous speech was limited, naming difficulties were apparent, and comprehension was mildly impaired. Though the patient ...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/0028-3932(82)90028-8
更新日期：1982-01-01 00:00:00
abstract：:A series of experiments explored the mechanisms determining the encoding and storage of features and objects in visual working memory. We contrasted the effects of three types of visual suffix on cued recall of a display of colored shapes. The suffix was presented after the display and before the recall cue. The latte...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2010.11.030
更新日期：2011-05-01 00:00:00
abstract：:In the antisaccade paradigm, subjects are instructed to fixate a central point, and then move their eyes towards a position in space in the opposite direction but equidistant to a peripheral, sudden onset target. Antisaccade errors occur when subjects are "distracted" by the target and make a saccade towards it. These...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/s0028-3932(01)00145-2
更新日期：2002-01-01 00:00:00
abstract：:In two ERP experiments, we examined the attention-related mechanism involved in perceiving infant emotions following exposure to security priming. Specifically, we examined how security priming affected securely and insecurely attached women. We found that both supraliminal and subliminal security priming resulted in ...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2019.107216
更新日期：2019-11-01 00:00:00
abstract：:Behavioural findings indicate that the core executive functions of inhibition and working memory are closely linked, and neuroimaging studies indicate overlap between their neural correlates. There has not, however, been a comprehensive study, including several inhibition tasks and several working memory tasks, perfor...
journal_title：Neuropsychologia
pub_type： 杂志文章
doi：10.1016/j.neuropsychologia.2008.04.023
更新日期：2008-09-01 00:00:00
