Abstract：
BACKGROUND:Sinus histiocytosis with massive lymphadenopathy, also known as Rosai-Dorfman disease, is a rare condition, classically characterized by painless, massive cervical lymphadenopathy. Histologically, the pathognomonic findings include a dense, mixed inflammatory infiltrate with areas of emperipolesis. Albeit infrequent, when Rosai-Dorfman disease affects the central nervous system, it typically manifests as an isolated dural lesion, often mimicking a meningioma. A purely intraparenchymal manifestation of Rosai-Dorfman disease of the brain and spine with absent dural involvement is exceedingly rare. CASE DESCRIPTION:In this report, we describe a 59-year-old woman who underwent surgical excision of an intraparenchymal cerebellar lesion. Histologic analysis of the resected specimen diagnosed isolated Rosai-Dorfman disease with absent systemic involvement. We also provide an updated review of the literature of nondural-based Rosai-Dorfman disease in the central nervous system. CONCLUSIONS:With the recent increase of such reported cases, it becomes imperative that Rosai-Dorfman be considered more than as a dural lesion that may mimic meningioma. Diagnostic and therapeutic challenges surrounding this disease entity are also discussed.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Hong CS,Starke RM,Hays MA,Mandell JW,Schiff D,Asthagiri ARdoi
10.1016/j.wneu.2016.02.121subject
Has Abstractpub_date
2016-06-01 00:00:00pages
702.e13-702.e20eissn
1878-8750issn
1878-8769pii
S1878-8750(16)00369-7journal_volume
90pub_type
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更新日期：2010-06-01 00:00:00
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