Lonidamine-induced outer membrane permeability and susceptibility of mitochondria to inhibition by adriamycin.

abstract：BACKGROUND:Lung resistance-related protein (LRP) was first detected in a non-P-glycoprotein-mediated multidrug-resistant lung cancer cell line and has been shown to be the major human vault protein. The aim of this study was to evaluate the expression of LRP in germ cell testicular tumors (GCT) and to determine the cor...

journal_title：Anticancer research

authors： Mándoky L,Géczi L,Doleschall Z,Bodrogi I,Csuka O,Kásler M,Bak M

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND/AIM:We aimed to analyze the clinical impact of solid and micropapillary components in a series of Japanese patients resected for ≤3 cm lung adenocarcinoma. PATIENTS AND METHODS:A total of 115 patients with ≤3 cm lung adenocarcinomas were reviewed and classified according to the American Thoracic Society and...

journal_title：Anticancer research

authors： Matsuoka Y,Yurugi Y,Takagi Y,Wakahara M,Kubouchi Y,Sakabe T,Haruki T,Araki K,Taniguchi Y,Nakamura H,Umekita Y

更新日期：2016-09-01 00:00:00

abstract：:The aim of this study was to investigate the relationship between Technetium-99m (Tc-99m) tetrofosmin accumulation in tumors which may represent the expression of multidrug resistance (MDR)--mediated P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP) as well as response to chemotherapy in patients ...

journal_title：Anticancer research

authors： Kao CH,Ho YJ,Shen YY,Lee JK

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND/AIM:Tumor recurrence complicates more than half of patients at 5 years after primary hepatocellular carcinoma (HCC) resection. Repeat open liver resection (ROLR) is the standard procedure for patients eligible for repeat resection, whereas laparoscopic repeat liver resection (RLLR) has been proposed as an al...

journal_title：Anticancer research

authors： Machairas N,Papaconstantinou D,Stamopoulos P,Prodromidou A,Garoufalia Z,Spartalis E,Kostakis ID,Sotiropoulos GC

更新日期：2018-05-01 00:00:00

abstract：AIM:To evaluate the role of low mechanical index (MI) contrast-enhanced sonography (CEUS) for the characterization of small hepatocellular carcinomas (HCC) in cirrhotic patients by comparing the results to ultrafast dynamic gadolinium-enhanced magnetic resonance imaging (MRI) studies. MATERIALS AND METHODS:Between Sep...

journal_title：Anticancer research

authors： Giorgio A,De Stefano G,Coppola C,Ferraioli G,Esposito V,Di Sarno A,Giorgio V,De Stefano M,Sangiovanni V,Liorre G,Del Viscovo L

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:To further evaluate lung cancer risk associated with rare Hras1 VNTR alleles and possible biological mechanisms. MATERIALS AND METHODS:The Hras1 VNTR was genotyped in 295 lung cancer patients and 500 healthy controls by PCR and high resolution electrophoresis. Microsatellite alterations were examined in 168 tu...

journal_title：Anticancer research

authors： Lindstedt BA,Ryberg D,Zienolddiny S,Khan H,Haugen A

更新日期：1999-11-01 00:00:00

abstract：AIM:The aim of the present study was to evaluate the correlation between WT1 expression levels and clinical features, to investigate the prognostic value of WT1 expression and to use lentiviral constructs to examine whether overexpression of WT1 affects cell proliferation and invasion in ovarian cancer patients. MATER...

journal_title：Anticancer research

authors： Liu Z,Yamanouchi K,Ohtao T,Matsumura S,Seino M,Shridhar V,Takahashi T,Takahashi K,Kurachi H

更新日期：2014-05-01 00:00:00

abstract：AIM:To investigate the prognostic significance of cancer antigen 15-3 (CA15-3) in primary breast cancer (BC). PATIENTS AND METHODS:This prospective study included 368 women: 62 patients with benign breast disease (BBD), 159 patients with invasive BC and 88 healthy blood donors (control). The median follow-up was 76 mo...

journal_title：Anticancer research

authors： Nisman B,Maimon O,Allweis T,Kadouri L,Maly B,Hamburger T,Peretz T

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:To assess the prophylactic efficacy of postoperative single intravesical instillation with pirarubicin (THP) and mitomycin C (MMC) for low-risk non-muscle-invasive bladder cancer (NMBC). PATIENTS AND METHODS:A total of 103 clinically low-risk NMBC patients were preoperatively randomized into either THP (n=4...

journal_title：Anticancer research

authors： Yamamoto S,Kageyama Y,Fujii Y,Aizawa T,Urakami S,Fukui I

更新日期：2020-09-01 00:00:00

abstract：AIM:This study assessed the symptoms and health-related quality of life (HRQOL) of patients with advanced non-small cell lung cancer (NSCLC) and examined the symptom-associated characteristics. PATIENTS AND METHODS:The symptoms of 122 patients with NSCLC scheduled for chemotherapy before starting treatment were survey...

journal_title：Anticancer research

authors： Silvoniemi M,Vasankari T,Löyttyniemi E,Valtonen M,Salminen E

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND/AIM:Several epidemiological studies have reported the chemopreventive potential of biochanin A, in cancer development and progression. We investigated the anticancer potential of combination of biochanin A and temozolomide against U-87 MG and T98 G [glioblastoma multiforme (GBM)] cells. MATERIALS AND METHOD...

journal_title：Anticancer research

authors： Desai V,Jain A,Shaghaghi H,Summer R,Lai JCK,Bhushan A

更新日期：2019-01-01 00:00:00

abstract：:Homogeneous subpopulations, which are endowed with low or high metastatic potential, were selected from Lewis lung carcinoma (3LL) in an attempt to correlate metastatic phenotype with specific properties of tumor cells. Since the growth of malignant cells at secondary sites could depend on their ability to respond to ...

journal_title：Anticancer research

authors： Perrotti D,Cimino L,Falcioni R,Tibursi G,Gentileschi MP,Sacchi A

更新日期：1990-11-01 00:00:00

abstract：:Three sublines have been derived from the parental line Mv1Lu by transfection with normal and mutated Ha-ras, and myc oncogenes, and subsequent cloning. All the oncogenes have increased the growth rate of the cell in vitro, increased their plating efficiency in monolayer and suspension, and reduced their serum depende...

journal_title：Anticancer research

authors： Khan MZ,Spandidos DA,Kerr DJ,McNicol AM,Lang JC,De Ridder L,Freshney RI

更新日期：1991-05-01 00:00:00

abstract：AIM:To examine patterns of clinical practice in locally advanced esophageal cancer among US radiation oncologists after publication of the CROSS trial. MATERIALS AND METHODS:US radiation oncologists were surveyed on 13 questions pertaining to the management of esophageal cancer. Respondents' demographics and their cli...

journal_title：Anticancer research

authors： Elliott DA,Rana SR,Nabavizadeh N,Chen Y,Kusano A,Holland JM,Mitin T

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:For eradicating portal venous tumor extension and intrahepatic metastasis in hepatocellular carcinoma (HCC), anatomical resection is, in theory, preferable. PATIENTS AND METHODS:We carried-out a retrospective cohort study in 110 patients who underwent curative hepatic resection (anatomical resection; n=20, ...

journal_title：Anticancer research

authors： Yamashita Y,Imai D,Bekki Y,Takeishi K,Tsujita E,Ikegami T,Yoshizumi T,Ikeda T,Shirabe K,Ishida T,Maehara Y

更新日期：2014-08-01 00:00:00

abstract：:260 CB57BL/J6 mice were used in an experimental protocol designed to investigate the effects of 4 different varieties of splenectomy on the growth rate of subcutaneously implanted GB-16 melanoma. In addition, the mean and absolute survival of the mice, the histopathology of the tumour and the effects of the same proce...

journal_title：Anticancer research

authors： Fotiadis C,Zografos G,Aronis K,Troupis TG,Gorgoulis VG,Sechas MN,Skalkeas G

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Cancer of the small intestine is a rare disease, and its clinical features have not been clearly elucidated. Techniques such as double balloon endoscopy and capsule endoscopy allow the preoperative diagnosis of cancer of the small intestine, but this cancer is often detected at an advanced state and in many ...

journal_title：Anticancer research

authors： Higashi D,Ishibashi Y,Tamura T,Nii K,Egawa Y,Koga M,Tomiyasu T,Harimura T,Tanaka R,Futatsuki R,Noda S,Futami K,Maekawa T,Takaki Y,Hirai F,Matsui T

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:To improve long-term survival by reducing toxicity in intermediate stage Hodgkin's disease patients, we compared the effects of involved field (IF) versus extended field (EF) irradiation administered after four cycles of ABVD regimen. MATERIALS AND METHODS:Two hundred and ten Hodgkin's disease patients, at ...

journal_title：Anticancer research

authors： Anselmo AP,Cavalieri E,Osti FM,Cantonetti M,De Sanctis V,Alfo M,Amadori S,Enrici RM

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Microparticles are known to be increased in various malignancies. In this prospective study, microparticle levels were evaluated in patients with benign and malignant ovarian lesions. PATIENTS AND METHODS:Microparticles from platelets/megakaryocytes, activated platelets and endothelial cells, tissue factor ...

journal_title：Anticancer research

authors： Rank A,Liebhardt S,Zwirner J,Burges A,Nieuwland R,Toth B

更新日期：2012-05-01 00:00:00

abstract：:Hepatocellular carcinoma is one of the most common malignancies in the world, with the liver being the second most frequently involved organ in metastatic disease. Although the gold standard treatment for malignant liver disease is surgical resection, only few patients can undergo such an intervention. This explains t...

journal_title：Anticancer research

authors： Poggi G,Riccardi A,Quaretti P,Teragni C,Delmonte A,Amatu A,Saini G,Mazzucco M,Bernardo A,Palumbo R,Canto A,Bernieri S,Bernardo G

更新日期：2007-07-01 00:00:00

abstract：:Concomitant neoplasm and abdominal aortic aneurysm (AAA) is not a rare clinical association and can pose problems if antiblastic treatment is required. The literature shows lack of consensus owing to the fact that AAA can modify the liquid load and the hemodynamic setting so that chemotherapy toxicity profile becomes ...

journal_title：Anticancer research

authors： Lauro S,Lanzetta G,Bria E,Trasatti L,Gelibter A,Vecchione A

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:The tumors of the gastrointestinal system have been associated with various immune disorders. The goal of this study was to correlate the presence of the anti-dsDNA autoantibodies in the serum of patients with colorectal adenocarcinoma suffering from the prognosis of their disease. PATIENTS AND METHODS:We i...

journal_title：Anticancer research

authors： Syrigos KN,Charalambopoulos A,Pliarchopoulou K,Varsamidakis N,Machairas A,Mandrekas D

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:This study aimed to elucidate the prognostic value of vimentin expression in patients with intrahepatic cholangiocarcinoma (ICC). PATIENTS AND METHODS:A retrospective analysis of 21 patients who underwent resection for ICC was conducted. Vimentin expression was positive when single tumour cells or cell clus...

journal_title：Anticancer research

authors： Korita PV,Wakai T,Ajioka Y,Inoue M,Takamura M,Shirai Y,Hatakeyama K

更新日期：2010-06-01 00:00:00

abstract：:We have developed a chemosensitivity assay of human tumors growing on collagen-sponge-gel-supported histoculture. This assay is thus termed the Histoculture Drug Response Assay (HDRA). In the HDRA, the end points of [3H]thymidine incorporation measured by histological autoradiography and tetrazolium dye reduction were...

journal_title：Anticancer research

authors： Chang SG,Chai SE,Kim ES,Yoon C,Joo HZ,Hoffman RM

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Our aim was to analyze the impact of intraperitoneal chemotherapy (IPC), administered with direct peritoneal puncture, on the survival of patients with pretreated ovarian cancer in a real-life setting. PATIENTS AND METHODS:This was a retrospective study comparing patients with advanced ovarian cancer treate...

journal_title：Anticancer research

authors： Nicoletto MO,Casarin A,Baldoni A,Rulli E,Tasca G,Baretta Z,Artioli G,Lombardi G,Cappetta A,Floriani I,Randon G,Valpione S,Litta P,Conte P,Mocellin S,Aliberti C

更新日期：2016-12-01 00:00:00

abstract：:Carcinogenesis is a process that converts normal cells from controllable to uncontrollable growth. Coordinate regulation of the rates of cell proliferation and cell death is an important determinant in maintenance of homeostasis. Loss of control of this balance is central to the development of cancer. This loss may be...

journal_title：Anticancer research

authors： Wang XW

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:It is unclear whether radiomic phenotypes of brain metastases (BM) are related to radiation therapy prognosis. This study assessed whether a convolutional neural network (CNN)-based radiomics model which learned computer tomography (CT) image features with minimal preprocessing, could predict early response ...

journal_title：Anticancer research

authors： Cha YJ,Jang WI,Kim MS,Yoo HJ,Paik EK,Jeong HK,Youn SM

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Bipolar radiofrequency ablation (RFA) can avoid complications such as thermal tissue damage, a possible consequence of monopolar RFA. However, basic studies about the dosage/effect relationship of bipolar systems are missing. This is systematic research on ex vivo beef livers to find which capacity parameter...

journal_title：Anticancer research

authors： Zurbuchen U,Frericks B,Roggan A,Lehmann K,Bössenroth D,Buhr HJ,Ritz JP

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to analyze the pretreatment cytokeratin serum levels in head and neck squamous cell carcinoma (HNSCC) by three assays in relation to selected clinicopathological characteristics in an effort to find diagnostic/prognostic biomarkers for HNSCC and determine the best assay. PATIEN...

journal_title：Anticancer research

authors： Kalfert D,Ludvik J,Kucera R,Topolcan O,Celakovsky P,Pesta M,Kholova I,Plzak J,Ludvikova M

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Mistletoe lectins (MLs) are the active components of aqueous mistletoe extracts widely used in complementary cancer therapy, however, it is not clear if they bind to carbohydrate residues only or whether they interact with proteins as well. Protein-protein interactions do not seem unlikely as MLs act at very...

journal_title：Anticancer research

authors： Nehmann N,Schade UM,Pfüller U,Schachner M,Schumacher U

更新日期：2009-12-01 00:00:00