Utility of DXA scanning and risk factors for osteoporosis in ankylosing spondylitis-A prospective study.


BACKGROUND:Conventional DXA imaging of spine and hip to measure bone mineral density (BMD) has limitations in patients with ankylosing spondylitis (AS). We investigated the correlation of hip and spine BMD measurements in patients with AS to determine if hip DXA will prove clinically useful while avoiding the confounding effect of spinal disease. Also, we studied risk factors for osteoporosis (OP) and osteopenia in AS. METHODS:We randomly identified patients from our validated AS registry ≥18 years of age who met the Modified New York Classification criteria for AS. BMD was measured and interpreted using ISCD 2007 guidelines and diagnosis of OP was based on WHO criteria. ESR, CRP, urinary N-telopeptide, and 25-hydroxy vitamin D were also measured. Correlation between the BMD (total hip and/or femoral neck) and lumbar spine was calculated. Statistical comparisons between the 2 sites, lumbar spine (AP) and hip (total hip and or femoral neck) were made using Bowker's test for symmetry and kappa statistics. Chi-square and odds ratio using logistic regression were used to assess the association of the purported risk factors for OP in these patients. RESULTS:Frequency of OP among AS patients ≥50 years of age was 23%, and that of osteopenia was 41%. Among patients <50 years of age, the frequency of low bone mass for expected age (Z-score ≤-2.0) was 14.7%. There was moderate correlation (ρ = 0.59) and a fair agreement (κ = 0.26; 95% CI: 0.10-0.42) between the lowest T-values of hip and lumbar spine (AP view). OP was significantly associated with elevated CRP level [OR = 4.2 (95% CI: 1.13-15.9), p < 0.03] and African American race [OR = 7.2 (95% CI: 1.18-44.99), p < 0.03]. CONCLUSION:Our results demonstrated a moderate correlation and fair agreement between the T-scores of hip and the lumbar spine (AP view) in patients with AS, suggesting that DXA of the hip and the lumbar spine (AP view) may both be useful for OP and osteopenia screening in patients with AS without fused spines. We confirm the previous reports of an association of elevated CRP level with an increased risk of OP in patients with AS, but this is the first study to demonstrate that African American patients with AS may be at a higher risk of developing OP compared to Caucasians.


Semin Arthritis Rheum


Magrey MN,Lewis S,Asim Khan M




Has Abstract


2016-08-01 00:00:00














  • Determinants of morbidity and mortality of systemic sclerosis in Canada.

    abstract:OBJECTIVES:To describe the morbidity and mortality in Canadian scleroderma (SSc) patients focusing on gender, SSc type, and organ-specific prognosis in a cohort of patients seen from 1994 to 2004 in a Southwestern Ontario SSc clinic. We also compared this cohort to data from the literature, which showed that mean survi...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Al-Dhaher FF,Pope JE,Ouimet JM

    更新日期:2010-02-01 00:00:00

  • High prevalence of hypovitaminosis D in Morocco: relationship to lifestyle, physical performance, bone markers, and bone mineral density.

    abstract:OBJECTIVES:We undertook this study to determine the prevalence of hypovitaminosis D, its determinants, and its relationships to physical performance, serum parathyroid hormone (PTH) concentration, bone mineral density, and biochemical markers of bone turnover in healthy, ambulatory, pre- and postmenopausal women. METH...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Allali F,El Aichaoui S,Khazani H,Benyahia B,Saoud B,El Kabbaj S,Bahiri R,Abouqal R,Hajjaj-Hassouni N

    更新日期:2009-06-01 00:00:00

  • Anti-TNF-α therapy in refractory uveitis associated with sarcoidosis: Multicenter study of 17 patients.

    abstract:OBJECTIVES:To assess anti-TNF-α therapy response in uveitis associated with sarcoidosis refractory to conventional immunosuppressive therapy. METHODS:Open-label, multicenter, retrospective study on patients with sarcoid uveitis who underwent anti-TNF-α therapy because of inadequate response to conventional therapy inc...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,多中心研究


    authors: Riancho-Zarrabeitia L,Calvo-Río V,Blanco R,Mesquida M,Adan AM,Herreras JM,Aparicio Á,Peiteado-Lopez D,Cordero-Coma M,García Serrano JL,Ortego-Centeno N,Maíz O,Blanco A,Sánchez-Bursón J,González-Suárez S,Fonollosa A,Santos

    更新日期:2015-12-01 00:00:00

  • Spontaneous pyogenic facet joint infection.

    abstract:OBJECTIVE:To analyze the clinical features, approaches to management, and outcome of spontaneous pyogenic facet joint infection (PFJI) in adults. PATIENTS AND METHODS:Case series of 10 adults with microbiologically proven PFJI diagnosed during a 10-year period in a teaching hospital, plus a review of 32 additional cas...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Narváez J,Nolla JM,Narváez JA,Martinez-Carnicero L,De Lama E,Gómez-Vaquero C,Murillo O,Valverde J,Ariza J

    更新日期:2006-04-01 00:00:00

  • Cytokine production by hepatic anaplastic large-cell lymphoma presenting as a rheumatic syndrome.

    abstract:OBJECTIVES:A variety of malignancies can present as rheumatic syndromes. Our aim was to describe a case of primary hepatic anaplastic large-cell lymphoma (ALCL) presenting as a rheumatic syndrome. We also describe cytokine production by the tumor. METHODS:A patient with ALCL presenting with arthralgia and systemic inf...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Siebert S,Amos N,Williams BD,Lawson TM

    更新日期:2007-08-01 00:00:00

  • Intra-articular hyaluronans: a review of product-specific safety profiles.

    abstract:BACKGROUND AND OBJECTIVES:Intra-articular (IA) hyaluronans (HAs) are indicated for pain relief of osteoarthritis (OA) of the knee. Hyalgan (sodium hyaluronate), Supartz (sodium hyaluronate), and Synvisc (hylan G-F 20) are Food and Drug Administration-approved HA products. They are derived from rooster combs; Hyalgan an...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Hamburger MI,Lakhanpal S,Mooar PA,Oster D

    更新日期:2003-04-01 00:00:00

  • Clinical efficacy and safety of denosumab in postmenopausal women with low bone mineral density and osteoporosis: a meta-analysis.

    abstract:OBJECTIVE:Clinical trials indicate that denosumab could be a potential treatment for postmenopausal osteoporosis. The objective of this meta-analysis was to assess the clinical efficacy and safety of offering denosumab to postmenopausal women with low bone mass. METHODS:Data sources included MEDLINE, EMBASE, and Cochr...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,meta分析


    authors: von Keyserlingk C,Hopkins R,Anastasilakis A,Toulis K,Goeree R,Tarride JE,Xie F

    更新日期:2011-10-01 00:00:00

  • Pulmonary disease during the treatment of rheumatoid arthritis with low dose pulse methotrexate.

    abstract::Methotrexate therapy has been effective in the treatment of RA with short term experience suggesting little serious adverse reactions. Our review of 168 patients receiving methotrexate has identified nine patients with probable or possible methotrexate-induced pulmonary toxicity, giving a prevalence of 5% and an incid...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Carson CW,Cannon GW,Egger MJ,Ward JR,Clegg DO

    更新日期:1987-02-01 00:00:00

  • Progressive bilateral lipoma arborescens of the knee complicated by juvenile spondyloarthropathy: a case report and review of the literature.

    abstract:OBJECTIVES:To report an unusual case of lipoma aborescens (LA) presented in a patient with treatment-responsive juvenile spondyloarthropathy (JSPA) and to summarize the clinical manifestations, therapy and prognosis of LA by literature review. METHODS:We report an atypical case of a 17-year-old patient with an initial...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Xue J,Alario AJ,Nelson SD,Wu H

    更新日期:2013-10-01 00:00:00

  • A cohort study reveals myocarditis to be a rare and life-threatening presentation of large vessel vasculitis.

    abstract:BACKGROUND:The predominant forms of adult large vessel vasculitis (LVV) are giant cell arteritis (GCA) and Takayasu arteritis (TA). Cardiac involvement in LVV is a cause of morbidity and mortality, particularly in TA. Cardiac failure is most commonly secondary to uncontrolled arterial hypertension or myocardial ischaem...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Bechman K,Gopalan D,Nihoyannopoulos P,Mason JC

    更新日期:2017-10-01 00:00:00

  • Sparing effect of hemiplegia on skin fibrosis and microvascular involvement: reports of two cases of systemic sclerosis and review of the literature.

    abstract:OBJECTIVES:The sparing effect of hemiplegia in rheumatic diseases has been described, but reports on systemic sclerosis (SSc)-spectrum disorders are unusual. SSc-spectrum disorders are complex diseases of unknown origin characterized by multisystem involvement, skin and organ fibrosis, microvascular alterations, and im...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Ughi N,Hervey SA,Gualtierotti R,Silvana Z,Herrick AL,Ingegnoli F,Meroni P

    更新日期:2015-04-01 00:00:00

  • Association of anti-cyclic citrullinated protein antibodies, erosions, and rheumatoid factor with disease activity and work productivity: A patient registry study.

    abstract:OBJECTIVES:To evaluate associations between the presence of anti-cyclic citrullinated protein antibodies (anti-CCP) and rheumatoid factor (RF) and other outcomes, including joint erosions and both clinical and economic endpoints, in patients with rheumatoid arthritis (RA). METHODS:Data from the Brigham and Women's Hos...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Alemao E,Guo Z,Frits ML,Iannaccone CK,Shadick NA,Weinblatt ME

    更新日期:2018-04-01 00:00:00

  • Epidemiological and clinical aspects relating to the variability of rheumatoid arthritis.

    abstract:OBJECTIVE:To review epidemiological studies dealing with the temporal and geographic variability in the occurrence of rheumatoid arthritis (RA) and clinical studies that address the variability of severity and manifestations among populations. METHODS:An extensive search of the literature, including a Medline search, ...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Abdel-Nasser AM,Rasker JJ,Valkenburg HA

    更新日期:1997-10-01 00:00:00

  • Autosplenectomy and antiphospholipid antibodies in systemic lupus erythematosus: A pathogenetic relationship?

    abstract:OBJECTIVES:To describe a systemic lupus erythematosus (SLE) patient with functional asplenia and antiphospholipid syndrome (APS) and to review the literature to better define its pathogenesis and diagnosis, emphasizing a possible relationship with antiphospholipid antibodies (aPL). METHODS:Descriptive report of 1 case...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Santilli D,Govoni M,Prandini N,Rizzo N,Trotta F

    更新日期:2003-10-01 00:00:00

  • Physical (in)activity and its influence on disease-related features, physical capacity, and health-related quality of life in a cohort of chronic juvenile dermatomyositis patients.

    abstract:OBJECTIVES:To objectively measure physical activity levels in a cohort of juvenile dermatomyositis (JDM) patients; to compare physical capacity and health-related quality of life in JDM patients and their healthy controls (CTRL) matched by physical activity levels; and to associate physical activity variables with dise...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Pinto AJ,Yazigi Solis M,de Sá Pinto AL,Silva CA,Maluf Elias Sallum A,Roschel H,Gualano B

    更新日期:2016-08-01 00:00:00

  • Immune-mediated inner ear disease: 10-year experience.

    abstract:BACKGROUND:Autoimmune inner ear disease (AIED) was first described in 1979 and the disease has become more widely recognized over the last decade. Limited information is available regarding clinical features of the disease, disease course, and response to treatment. OBJECTIVE:To analyze data from 42 patients with docu...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Broughton SS,Meyerhoff WE,Cohen SB

    更新日期:2004-10-01 00:00:00

  • Tumor necrosis factor inhibitors: clinical implications of their different immunogenicity profiles.

    abstract::The beneficial effects of the anti-tumor necrosis factor (TNF) monoclonal antibodies infliximab and adalimumab and the soluble receptor fusion protein etanercept in the treatment of rheumatoid arthritis and a variety of other inflammatory disorders have been well described. However, less is known about the propensity ...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Anderson PJ

    更新日期:2005-04-01 00:00:00

  • Amyloid arthropathy associated with multiple myeloma: a systematic analysis of 101 reported cases.

    abstract:OBJECTIVE:Amyloid deposition in multiple myeloma (MM) may lead to an arthropathy resembling rheumatoid arthritis (RA). Since a systematic description of its natural history is lacking, we have performed a systematic analysis of all published cases. METHODS:Literature review featuring backward and forward database sear...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Elsaman AM,Radwan AR,Akmatov MK,Della Beffa C,Walker A,Mayer CT,Dai L,Nativ S,Rygg M,Atsali E,Saijo K,Ogdie AR,Srinivasulu N,Fathi N,Schumacher HR,Pessler F

    更新日期:2013-12-01 00:00:00

  • Assessing the impact of psoriatic arthritis on patient function and quality of life: lessons learned from other rheumatologic conditions.

    abstract:OBJECTIVES:To identify and describe measures that can be used to assess the impact of psoriatic arthritis (PsA) on patient functioning and health-related quality of life (HRQOL). METHODS:A literature search of the PubMed database to identify papers describing assessment tools for quality of life and function in rheuma...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Mease PJ

    更新日期:2009-02-01 00:00:00

  • Racial disparities in the risk of Stevens-Johnson Syndrome and toxic epidermal necrolysis as urate-lowering drug adverse events in the United States.

    abstract:OBJECTIVES:HLA-B*5801 allele carriage (a strong determinant of allopurinol hypersensitivity syndrome) varies substantially among races, which may lead to racial disparities in the risk of Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) in the context of urate-lowering drug adverse events (ULDAEs). W...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Lu N,Rai SK,Terkeltaub R,Kim SC,Menendez ME,Choi HK

    更新日期:2016-10-01 00:00:00

  • The ocular safety of hydroxychloroquine.

    abstract::The insert currently supplied with hydroxychloroquine states that patients should have an initial ophthalmological assessment and then regular assessments every 3 months. The rheumatologist should expect a report from the ophthalmologist, which includes a corneal assessment of tissue dose, a reference to visual field ...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Easterbrook M

    更新日期:1993-10-01 00:00:00

  • Toxoplasmic chorioretinitis and antitumor necrosis factor treatment in rheumatoid arthritis.

    abstract:OBJECTIVES:To present the data supporting the possible relationship of ocular toxoplasmosis to antitumor necrosis factor-alpha (TNF-alpha) therapy in patients with rheumatoid arthritis (RA). METHODS:A Medline search was performed using the words "toxoplasmosis, anti-TNF-alpha antagonists, chorioretinitis." We report 2...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Lassoued S,Zabraniecki L,Marin F,Billey T

    更新日期:2007-02-01 00:00:00

  • Unmet needs in the treatment of rheumatoid arthritis. An observational study and a real-life experience from a single university center.

    abstract:OBJECTIVES:To estimate the size of unmet needs in the treatment of early Rheumatoid Arthritis (eRA), using all the conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and/or biological DMARDs (bDMARDs) in a long-term observational study. MATERIALS AND METHODS:538 patients with eRA were evaluated. T...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Kaltsonoudis E,Pelechas E,Voulgari PV,Drosos AA

    更新日期:2019-02-01 00:00:00

  • What is the prevalence of cognitive impairment in lupus and which instruments are used to measure it? A systematic review and meta-analysis.

    abstract:OBJECTIVES:To systematically review the literature on the prevalence of Cognitive Dysfunction (CD) in SLE patients in studies that used a specified neuropsychological instrument. METHODS:This review was prepared with a protocol following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis-Protocols ...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,meta分析


    authors: Rayes HA,Tani C,Kwan A,Marzouk S,Colosimo K,Medina-Rosas J,Mustafa A,Su J,Lambiris P,Mosca M,Touma Z

    更新日期:2018-10-01 00:00:00

  • A descriptive analysis of 14 cases of progressive-psuedorheumatoid-arthropathy of childhood from south India: review of literature in comparison with juvenile idiopathic arthritis.

    abstract:BACKGROUND:Progressive-psuedorheumatoid-arthropathy of childhood (PPAC) is an autosomal recessive single gene skeletal dysplasia involving joints. The gene attributed to its cause is WNT1-inducible-signaling pathway protein3 (WISP3). OBJECTIVE:To study the clinical and radiographic presentation of PPAC in Indian patie...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Ekbote AV,Danda D,Kumar S,Danda S,Madhuri V,Gibikote S

    更新日期:2013-06-01 00:00:00

  • Primary preventive services in patients with systemic lupus erythematosus: study from a population-based sample in Southeast U.S.

    abstract:OBJECTIVES:Systemic lupus erythematosus (SLE) patients are at risk for complications that can be mitigated by appropriate preventive care. We examined the receipt of immunizations, cancer screening, and cardiovascular risk preventive services in a predominantly Black cohort of SLE patients from the Southeast U.S. To id...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Drenkard C,Rask KJ,Easley KA,Bao G,Lim SS

    更新日期:2013-10-01 00:00:00

  • Anti-nuclear antibody development is associated with poor treatment response to biological disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis.

    abstract:BACKGROUND:It has been well known that TNF-α inhibitor (TNFi) treatment for patients with rheumatoid arthritis (RA) is associated with anti-nuclear antibody (ANA) development. We previously reported that ANA development was associated with poor outcomes of infliximab (IFX) treatment (1). However, no replication studies...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Ishikawa Y,Hashimoto M,Ito H,Tanaka M,Yukawa N,Fujii T,Yamamoto W,Mimori T,Terao C

    更新日期:2019-10-01 00:00:00

  • A case of bilateral trochleitis in adult-onset Still's disease.

    abstract:OBJECTIVES:We describe the first case of adult-onset Still's disease (AOSD) presenting with trochleitis and successfully treated with an interleukin-1 receptor antagonist. METHODS:This is a descriptive case report of one patient, identified in consultation with the inpatient ophthalmology consult service. RESULTS:A 2...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Gutmark R,Eliasieh K,Rivera-Michlig R

    更新日期:2014-04-01 00:00:00

  • Standards of care for inflammatory arthritis: A literature review.

    abstract:OBJECTIVE:Quality standards are tools that may be used for advocacy, education, and for quality improvement purposes. The objective of this review is to describe the current landscape of quality standards for inflammatory arthritis (including rheumatoid arthritis, juvenile idiopathic arthritis, and spondyloarthritis), ...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Wilson BA,Cooper M,Barber CEH

    更新日期:2017-08-01 00:00:00

  • The changing spectrum of rheumatic disease in human immunodeficiency virus infection.

    abstract:CONTEXT:Although it has been known for over 15 years that a number of rheumatic diseases occur in patients with human immunodeficiency virus (HIV) infection, increasing knowledge about these disorders and advances in HIV treatment need to be considered in approaching patients with HIV-associated rheumatic disease. OBJ...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Reveille JD

    更新日期:2000-12-01 00:00:00