Abstract：
BACKGROUND AND OBJECTIVE:Recurrence is a major problem in craniopharyngioma (CP) management. Recent study shows that high FABP5/CRABPII may be related to tumor growth and that all-trans retinoic acid (ATRA) may suppress primary CP growth. We studied the expression profile of FABP5 and CRABPII in recurrent CP tissue and the effect of ATRA on recurrent CP cells. METHODS:Fifty cases of patients with CP were enrolled in the retrospective study. Among them, 15 were recurrent. Fresh specimens were collected for immunohistochemistry, reverse transcription polymerase chain reaction, and western blotting analysis of FABP5 and CRABPII. Fresh specimens from 6 primary and recurrent CPs were collected and subjected to cell culture using an explants method. ATRA at various concentrations was applied to recurrent CP cell culture, and cell growth was recorded and analyzed. RESULTS:Immunohistochemistry, reverse transcription polymerase chain reaction, and western blot study showed that FABP5 was expressed significantly higher in recurrent tumors, whereas CRABPII was expressed significantly higher in primary tumors. The FABP5/CRABPII ratio was significantly higher in recurrent rather than primary tumors. Recurrent CP cells grew faster than primary cells, and ATRA induced cellular apoptosis and inhibited CP cell growth in a dose-dependent manner. CONCLUSIONS:A high expression ratio between FABP5 and CRABPII may be related to CP tumor recurrence and ATRA could be a potential therapeutic agent for CP chemotherapy.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Li Q,You C,Zhou L,Sima X,Liu Z,Liu H,Xu Jdoi
10.1016/j.wneu.2016.05.063subject
Has Abstractpub_date
2016-10-01 00:00:00pages
197-205eissn
1878-8750issn
1878-8769pii
S1878-8750(16)30337-0journal_volume
94pub_type
杂志文章abstract：BACKGROUND:Ossified posterior longitudinal ligament (OPLL) of the cervical spine can lead to spinal stenosis and become clinically symptomatic. The optimal approach in addressing OPLL is a debated topic and dependent on factors such as preoperative lordosis and levels affected. METHODS:In this study, we retrospectivel...
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abstract：:A potential application of near-infrared (NIR) fluorescence imaging using second-window indocyanine green (SWIG) is demonstrated. We hypothesized that because the pituitary lacks a blood-brain barrier, we might visualize the pituitary stalk using SWIG. A 52-year-old, right-handed man presented to our clinic for evalua...
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更新日期：2018-06-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2016-07-01 00:00:00
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更新日期：2020-12-01 00:00:00
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更新日期：2018-08-01 00:00:00
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更新日期：2020-01-01 00:00:00
