The application value of the detection of the level of tissue polypeptide antigen, ovarian cancer antigen X1, cathepsin L and CA125 on the diagnosis of epithelial ovarian cancer.

Abstract:

OBJECTIVE:We investigated the value of the joint detection of tissue polypeptide antigen (TPA), ovarian cancer antigen X1 (OVX1), cathepsin L (CTSL) and CA125 on the early diagnosis of epithelial ovarian carcinoma (EOC). PATIENTS AND METHODS:From October 2011 to February 2015, 84 cases of patients under surgical treatment of epithelial ovarian cancer, 98 cases of patients with benign epithelial ovarian tumor and 51 subjects in healthy control group were selected to detect the level of TPA, OVX1 and CTSL in serum from the Obstetrics and Gynecology Department of the First Affiliated Hospital of Liaoning Medical University. The clinical data of patients with ovarian tumor were collected and analyzed, and the levels of CA12 were measured. RESULTS:3 indicators in the malignant group were significantly higher than those in the benign group and healthy control group (p < 0.05). The total positive rate and the positive rate of early detection of TPA on EOC were the highest, and the total positive rate of OVX1 was lower than that of CA125. The total positive rate and the positive rate of early detection of CA125+TPA on EOC were the highest. The positive rate of early detection and the total positive rate of the pairwise combined detection of the other index and CA125 on EOC were significantly higher than those of the single detection of CA125 (p < 0.05). The joint detection of CA125+ OVX1 and the single detection of CA125 were not statistically significant. However, the remaining differences were statistically significant (p < 0.05). CONCLUSIONS:The level of TPA, OVX1 and CTSL in serum was potential detection index, the joint detection of TPA and CA125 was the ideal combination, which took into account the total positive rate, the positive rate of early detection on EOC and the improved diagnostic rate of EOC.

authors

Lv XL,Zhu Y,Liu JW,Ai H

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

5113-5116

issue

24

eissn

1128-3602

issn

2284-0729

journal_volume

20

pub_type

杂志文章
  • Long noncoding RNA LINC00858 promotes the proliferation, migration and invasion of gastric cancer cells via the miR-363-3p/FOXP4 axis.

    abstract:OBJECTIVE:Long non-coding RNA (lncRNA) LINC00858 has been found to exert oncogenic activity in several types of cancers, except gastric cancer (GC). In the present study, we aimed to explore the potential role of LINC00858 in GC and the underlying molecular mechanism. PATIENTS AND METHODS:The expression patterns of LI...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202009_23022

    authors: Ma HF,He WW,Wang JJ

    更新日期:2020-09-01 00:00:00

  • Trial with Platelet-Rich Fibrin and Bio-Oss used as grafting materials in the treatment of the severe maxillar bone atrophy: clinical and radiological evaluations.

    abstract:OBJECTIVES:The aim of the present study is to assess the implant osteointegration, as well as the course of bone regeneration and healing processes, thanks to the sinus lift procedure and by using PRF as a filling material, in association with the Bio-Oss. MATERIALS AND METHODS:23 patients, requiring maxillary sinus l...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 临床试验,杂志文章

    doi:

    authors: Inchingolo F,Tatullo M,Marrelli M,Inchingolo AM,Scacco S,Inchingolo AD,Dipalma G,Vermesan D,Abbinante A,Cagiano R

    更新日期:2010-12-01 00:00:00

  • Evaluation of analgesic and anti-inflammatory effect of nanoparticles of magnesium oxide in mice with and without ketamine.

    abstract:OBJECTIVES:According to importance and increasing application of nanoparticles and their toxicity, the identification effects of nanoparticles on physiological systems are essential. Some studies show magnesium has analgesic effect in some pain models but this evaluation was not carried on nano-magnesium oxide (MgO). T...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Jahangiri L,Kesmati M,Najafzadeh H

    更新日期:2013-10-01 00:00:00

  • Long noncoding RNA ROR1‑AS1 overexpression predicts poor prognosis and promotes metastasis by activating Wnt/β-catenin/EMT signaling cascade in cervical cancer.

    abstract:OBJECTIVE:Several long noncoding RNAs (lncRNAs) display functional effects in the tumorigenesis and progression of cervical cancer (CC). We aimed to investigate the roles of lncRNA tyrosine protein kinase transmembrane receptor 1 antisense RNA 1 (ROR1‑AS1) in the development of CC patients. PATIENTS AND METHODS:Revers...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202003_20656

    authors: Zhang L,Yao HR,Liu SK,Song LL

    更新日期:2020-03-01 00:00:00

  • Spontaneous non-traumatic splenic artery aneurysm rupture: a case report and review of the literature.

    abstract::The current case report is about spontaneous non-traumatic rupture of a splenic artery aneurysm (SAA) in a 53-year-old woman with no particular medical history. An emergent laparotomy with splenectomy was required, unfortunately without success as the patient died. SAA is the most common visceral artery aneurysm. Most...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201805_15074

    authors: Martin D,Teixeira Farinha H,Dattner N,Rotman S,Demartines N,Sauvain MO

    更新日期:2018-05-01 00:00:00

  • Pneumocystis jirovecii pneumonia in a human immunodeficiency virus-infected patient with G6PD deficiency-successful treatment with anidulafungin.

    abstract:CASE REPORT:We reported a HIV-infected patient, diagnosed as PJP with G6PD deficiency. Pneumocystis jiroveci pneumonia (PJP) is the most common opportunistic infection in subjects with human immunodeficiency virus (HIV) infection. Trimethoprim-sulfamethoxazole (TMP-SMX) is the first line regimen for Pneumocystis jirove...

    journal_title:European review for medical and pharmacological sciences

    pub_type:

    doi:10.26355/eurrev_201812_16666

    authors: Chang HC,Yang WT,Chen TC

    更新日期:2018-12-01 00:00:00

  • Partial least squares based gene expression analysis in posttraumatic stress disorder.

    abstract:OBJECTIVE:Posttraumatic stress disorder (PTSD) is an adverse psychological response to traumatic events. Microarray technology for large-scale gene expression analysis facilitates the identification of signatures that underlie the pathogenesis of PTSD. Previous studies mostly used variance/regression analysis without c...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Dong K,Zhang F,Zhu W,Wang Z,Wang G

    更新日期:2014-08-01 00:00:00

  • USP22 down-regulation facilitates human retinoblastoma cell aging and apoptosis via inhibiting TERT/P53 pathway.

    abstract:OBJECTIVE:Retinoblastoma is the most common malignant intraocular tumor in childhood, and still lacks effective treatment. The immortality of tumor cell can be attributed to elevated telomerase activity, which has been considered as tumor marker and treatment target. USP22 is one of the important targets for inhibiting...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Zhou D,Liu P,Sun DW,Chen ZJ,Hu J,Peng SM,Liu YL

    更新日期:2017-06-01 00:00:00

  • Upregulation of LncRNA FAM83H-AS1 in hepatocellular carcinoma promotes cell proliferation, migration and invasion by Wnt/β-catenin pathway.

    abstract:OBJECTIVE:The long non-coding RNA, FAM83H antisense RNA 1 (head to head) (FAM83H-AS1), has been reported to function as an oncogene in some types of cancer. However, the role of lncRNA FAM83H-AS1 in hepatocellular carcinoma (HCC) still remains unknown. The present work aims to explore the effect of lncRNA FAM83H-AS1 on...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201909_18995

    authors: Ma YK,Shen TH,Yang XY

    更新日期:2019-09-01 00:00:00

  • Effect of propofol on myocardial ischemia/reperfusion injury in rats through JAK/STAT signaling pathway.

    abstract:OBJECTIVE:The aim of this study was to investigate the influences of propofol on myocardial ischemia/reperfusion injury in rats through the Janus kinase/signal transducers and the activators of transcription (JAK/STAT) signaling pathway. MATERIALS AND METHODS:A total of 48 Sprague-Dawley (SD) rats were randomly divide...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201907_18456

    authors: Chen X,Wang Y,Xiao ZY,Hou DN,Li DB,Zhang XP

    更新日期:2019-07-01 00:00:00

  • Combination therapy with hydrogen peroxide (4%), salicylic acid (0.5%) and D-panthenol (4%): efficacy and skyn tolerability in common acne vulgaris during sun exposure period.

    abstract:OBJECTIVE:Acne vulgaris is a disease of the sebaceous follicle which affects up to 90% of adolescent patients. Topical retinoids, benzoyl peroxide and antibiotics are the main treatments for mild to moderate acne vulgaris. The use of such topical treatments is often associated with local irritation and dryness making t...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Ricci F,Masini F,Fossati B,Frascione P,De Waure C,Capizzi R,Guerriero C

    更新日期:2016-01-01 00:00:00

  • Microarray based analysis of gene expression patterns in pancreatic neuroendocrine tumors.

    abstract:OBJECTIVE:Pancreatic neuroendocrine tumors (PanNETs) are a small subgroup of tumors with a variety of biological behaviors. MATERIALS AND METHODS:We sought to identify the specially expressed genes and characterize significant pathways in PanNETs compared with non-neoplastic samples. Gene expression profile GSE43795 w...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Wang DD,Liu ZW,Han MM,Zhu ZM,Tu YL,Dou CQ,Jin X,Cai SW,Du N

    更新日期:2015-09-01 00:00:00

  • miR-326 regulates EMT and metastasis of endometrial cancer through targeting TWIST1.

    abstract:OBJECTIVE:Endometrial carcinoma is the most common malignancy of the female genital tract. Therefore, there is an urgent need to understand the molecular mechanism of its metastasis. This study is aimed to explore the function and underlying mechanism of miR-326 in endometrial cancer (EC). PATIENTS AND METHODS:RT-PCR ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Liu W,Zhang B,Xu N,Wang MJ,Liu Q

    更新日期:2017-10-01 00:00:00

  • FABP4 inhibitor attenuates inflammation and endoplasmic reticulum stress of islet in leptin receptor knockout rats.

    abstract:OBJECTIVE:Metabolic syndrome is characterized by abdominal obesity, hypertriglyceridemia and hyperglycemia. Fatty acid binding protein 4 (FABP4), as a member of intracellular lipid chaperones, is not only engaged in lipid transport but involved in inflammation and insulin resistance. The present study was to investigat...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202012_24182

    authors: Yao F,Jiang DD,Guo WH,Guo LS,Gao MM,Bai Y,Wang X,Zhang LS

    更新日期:2020-12-01 00:00:00

  • Defining the biology of intrahepatic cholangiocarcinoma: molecular pathways and early detection of precursor lesions.

    abstract::Intrahepatic cholangiocarcinoma (ICC) is a rare malignant tumor of the biliary tract with growing incidence and dismal prognosis. It is responsible for 10-20% of primary liver cancer worldwide, but early diagnosis is still a challenge and few treatment options are available. Aim of this review is to summarize the curr...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Gibiino G,Fabbri C,Fagiuoli S,Ianiro G,Fornelli A,Cennamo V

    更新日期:2017-02-01 00:00:00

  • Predicting transcription factors in human alcoholic hepatitis from gene regulatory network.

    abstract:OBJECTIVE:Alcoholic hepatitis (AH) is a type of alcoholic liver disorder caused by overconsumption of alcohol. The involvement of several transcription factors (TF), as the main regulators of disease related gene expression has been documented previously. However, despite the importance of analysis of gene regulatory n...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Mohammadnia A,Yaqubi M,Fallahi H

    更新日期:2015-06-01 00:00:00

  • LncRNA GAS5 affects epithelial-mesenchymal transition and invasion of breast cancer cells by regulating miR-216b.

    abstract:OBJECTIVE:To study the mechanism of lncRNA GAS5 affecting epithelial-mesenchymal transition and invasion of breast cancer cells by regulating miR-216b. PATIENTS AND METHODS:Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was used to detect the expressions of GAS5 and miR-216b in breast cancer and paracancer...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202005_21176

    authors: Li Y,Guo XB,Wei YH

    更新日期:2020-05-01 00:00:00

  • CircRNA_100395 protects breast carcinoma deterioration by targeting MAPK6.

    abstract:OBJECTIVE:This study aims to uncover the differential expression of circRNA_100395 in breast carcinoma specimens, and its regulatory effect on cancer cell phenotypes. The role of circRNA_100395 in affecting breast carcinoma progression and the molecular mechanism are explored as well. PATIENTS AND METHODS:CircRNA_1003...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202012_24012

    authors: Yu XP,Liu CG,Qiu F,Xu YQ,Xing F,Yin JQ,Han SJ,Yu H,Han Y,Jing X,He GJ

    更新日期:2020-12-01 00:00:00

  • LncRNA ZNF667-AS1 inhibits inflammatory response and promotes recovery of spinal cord injury via suppressing JAK-STAT pathway.

    abstract:OBJECTIVE:The aim of this study was to explore the role of lncRNA ZNF667-AS1 in the recovery of spinal cord injury (SCI), and to investigate its underlying mechanism. MATERIALS AND METHODS:Mice were randomly assigned to the SCI group, the sham group and the lncRNA ZNF667-AS1 group, with 10 mice in each group. With Inf...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201811_16375

    authors: Li JW,Kuang Y,Chen L,Wang JF

    更新日期:2018-11-01 00:00:00

  • Influence of lncRNA ANRIL on neuronal apoptosis in rats with cerebral infarction by regulating the NF-κB signaling pathway.

    abstract:OBJECTIVE:The aim of this study was to evaluate the influence of long non-coding ribonucleic acid (lncRNA) antisense non-coding RNA in the INK4 locus (ANRIL) on neuronal apoptosis in rats with cerebral infarction (CI), and to further explore the underlying mechanism of lncRNA ANRIL in the occurrence and development of ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201911_19577

    authors: Zhao JH,Wang B,Wang XH,Wang JR,Xu CW

    更新日期:2019-11-01 00:00:00

  • Butorphanol protects on myocardial ischemia/reperfusion injury in rats through MAPK signaling pathway.

    abstract:OBJECTIVE:To explore the influence of butorphanol on myocardial ischemia/reperfusion (I/R) injury in rats through the mitogen-activated protein kinase (MAPK) signaling pathway. MATERIALS AND METHODS:The I/R model in Sprague-Dawley rats was established. The rats were randomly divided into normal group (n=20), myocardia...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201912_19695

    authors: Wang H,Wang JL,Ren HW,He WF,Sun M

    更新日期:2019-12-01 00:00:00

  • Observation of Kawasaki disease-related indexes and the study of relationship between myocardial enzyme changes and coronary artery lesions.

    abstract:OBJECTIVE:To discuss the significance of Kawasaki disease-related laboratory indicators and relationship between myocardial enzyme changes and myocardial enzyme changes in children with Kawasaki disease. PATIENTS AND METHODS:Make an observation of C-reactive proteins and immune globulin changes in children with Kawasa...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Niu L,An XJ,Fu MY,He XH,Wang QW

    更新日期:2015-11-01 00:00:00

  • Real-world effectiveness and safety of Guselkumab for the treatment of psoriasis: a 6-month prospective study in a series of psoriatic patients.

    abstract:OBJECTIVE:Guselkumab is a fully human monoclonal IgG1 antibody which, by selectively binding to the p19 subunit of IL-23, prevents it from binding to the IL-23 receptor on the cell surfaces. To date, no prospective data are available on the efficacy and safety of this drug in everyday clinical practice in patients with...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202101_24408

    authors: Malara G,Trifirò C,Bartolotta A,Giofré C,D'Arrigo G,Testa A,De Lorenzo A,Tripepi G

    更新日期:2021-01-01 00:00:00

  • miR-340 suppresses tumor growth and enhances chemosensitivity of colorectal cancer by targeting RLIP76.

    abstract:OBJECTIVE:Colorectal cancer (CRC) is a common human malignancy and is the second leading cause of cancer deaths worldwide with a dismal prognosis. Previous investigations have shown that miR-340 can modulate the metabolism of CRC cells. The aim of this report is to study the role of miR-340 in the development and progr...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Zhang LL,Xie FJ,Tang CH,Xu WR,Ding XS,Liang J

    更新日期:2017-06-01 00:00:00

  • The effects of interventional therapy on serum HTATIP2/TIP30, B7-H4 and short-term curative effect in primary hepatocellular carcinoma.

    abstract:OBJECTIVE:To explore the effects of interventional therapy on human immunodeficiency virus (HIV)-1 Tat interactive protein 2/Tat interactive protein 30 (HTATIP2/TIP30), B7-H4 and short-term curative effect in primary hepatocellular carcinoma. PATIENTS AND METHODS:62 patients with primary hepatocellular carcinoma admit...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.26355/eurrev_201810_16144

    authors: Zheng ZJ,Fu J,Zhi F,Liu WJ,Guo YJ,Zhu DD,Mo JG

    更新日期:2018-10-01 00:00:00

  • Cervical Intraepithelial Neoplasia (CIN) in pregnancy: the state of the art.

    abstract:OBJECTIVES:Cervical cancer is the most commonly diagnosed malignancy in pregnancy and cervical screening should be accordingly performed in this particular situation. Occurrence of a preneoplastic cervical disease in pregnancy has for a long time represented a challenge for the clinician, both in terms of diagnostic ac...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Origoni M,Salvatore S,Perino A,Cucinella G,Candiani M

    更新日期:2014-01-01 00:00:00

  • Association between NDRG2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats.

    abstract:OBJECTIVE:The aim of this study was to observe the association between N-myc downstream regulated gene 2 (NDRG2)/interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway and diabetic retinopathy (DR) in rats. MATERIALS AND METHODS:The model of diabetes was successfully establis...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202004_20806

    authors: Wang Y,Zhai WL,Yang YW

    更新日期:2020-04-01 00:00:00

  • In silico discovery of a perilipin 1 inhibitor to be used as a new treatment for obesity.

    abstract:BACKGROUND:Obesity is a chronic non-communicable disease that affects a lot of people worldwide. Current management strategies for obesity include dietary management, physical exercises and pharmacological agents but sustenance of weight loss is still a problem. Perilipin 1 is a lipid droplet protein that is involved i...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Noureldein MH

    更新日期:2014-01-01 00:00:00

  • FeNO levels in children with asthma and other diseases of the lung.

    abstract:BACKGROUND:Prolonged cough in children is one of the major complaints seen in hospitals. It is difficult to make a proper diagnosis and start the appropriate treatment. Fraction of exhaled nitric oxide (FeNO) measurement is a valuable non-invasive diagnostic tool in determining the cause of prolonged cough in children....

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Kelekçi S,Sen V,Yolbas I,Uluca Ü,Tan I,Gürkan MF

    更新日期:2013-11-01 00:00:00

  • Prospective study of preincisional single-dose ceftriaxone in reducing postoperative wound infection in high risk of infection patients.

    abstract:BACKGROUND/AIMS:The risk of wound contamination in high risk of infection patients after abdominal operations is well recognised. Preincisional intraparietal injection of antibiotics is used for the prophylaxis of postoperative surgical infections. Whether topically injected antibiotics remain primarily in the surgical...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 临床试验,杂志文章

    doi:

    authors: Petrakis I,Vrachassotakis N,Tsatsakis A,Chalkiadakis G

    更新日期:1998-05-01 00:00:00