Abstract:
:Many psychiatric patients experience pharmaceutical intolerances, and some of them do not derive optimal efficacy from their pharmacotherapies. Clinical problems such as these may result in prolonged dysfunction, adverse consequences, and repeated changes in medication treatment regimens. Pharmacogenomics is a laboratory method that aids individualized medication selection by predicting drug efficacy and adverse effect profiles. It is a technique that involves the testing of patients' genetic makeup to improve medicinal response and tolerance. Pharmacogenomics aims to clarify pharmacokinetics and pharmacodynamics in addition to focusing on hepatic cytochrome enzyme metabolism. Ultimately, it facilitates optimal selection and adjustment of medications to enhance clinical outcomes. Pharmacogenomics is most useful in cases in which routinely prescribed pharmacotherapies are either suboptimally effective or have unacceptable adverse effects. Once there has been a failure of a therapeutic drug treatment, rather than "blindly" selecting an alternative medicine, pharmacogenomic test results can provide guidance for the selection of the most appropriate drug and its dose. The intent is to yield a greater likelihood of patient success in following a therapeutic intervention.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Narang P,Johnson A,Enja M,Lippmann Sdoi
10.14423/SMJ.0000000000000534subject
Has Abstractpub_date
2016-10-01 00:00:00pages
628-630issue
10eissn
0038-4348issn
1541-8243pii
SMJ50262journal_volume
109pub_type
杂志文章abstract::To show the usefulness of the Society of Thoracic Surgeons (STS) National Database in providing clinical and cost-related outcome data, we studied 297 consecutive patients who had isolated coronary artery bypass grafting (CABG) and who were assigned to either a "fast track" or traditional track. The observed overall m...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199611000-00009
更新日期:1996-11-01 00:00:00
abstract::Sometimes physicians assume responsibilities to third parties when undertaking the care of patients. Physicians have been held liable to third parties, though strangers to the patients, for failing to warn regarding the communicability of contagious diseases. Two suits have been allowed against physicians by third par...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197606000-00031
更新日期:1976-06-01 00:00:00
abstract::We report the case of an 18-year old man with hemolytic-uremic syndrome (HUS) having a classic clinical presentation and diagnostic renal pathology without evidence of microangiopathic hemolytic anemia (MAHA) by peripheral blood smear. Indirect evidence of hemolysis was suggested by mild anemia, elevation of serum lac...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199603000-00018
更新日期:1996-03-01 00:00:00
abstract::Elderly patients with community-acquired pneumonia may not have a systemic inflammatory response characterized by fever and leukocytosis. We compared lack of fever and leukocytosis with mortality in elderly patients with community-acquired pneumonia. Patients with fever and leukocytosis (group A, 47 patients) were com...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199703000-00006
更新日期:1997-03-01 00:00:00
abstract::In a prospective study of the etiology of pneumonia in patients hospitalized at a university hospital, all respiratory secretions were tested for routine pathogens as well as Legionella. A diagnosis was established in 60 of 87 patients studied. Of the 37 nosocomial infections, six were caused by L micdadei. Gram-negat...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198604000-00007
更新日期:1986-04-01 00:00:00
abstract:OBJECTIVES:Patient safety event (PSE) reporting is a critical element for healthcare organizations that are striving for continuous quality improvement. Although resident physicians routinely provide the majority of direct patient care, the level of their participation in PSE reporting historically has been low. In add...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000486
更新日期:2016-07-01 00:00:00
abstract::Allergic rhinitis affects approximately 40% of children and generally presents in children from 10-19 years of age; however, the condition has been seen in children as young as 6 months. Antihistamines are commonly prescribed in infants and children for the relief of allergic symptoms. A 23-month-old male with a histo...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181b9ae49
更新日期:2010-05-01 00:00:00
abstract::This report describes a 9-year-old girl with pigmented villonodular synovitis of the right knee. She presented with a chronic bloody effusion of the knee. The diagnosis of pigmented villonodular synovitis was suggested by the findings on magnetic resonance imaging and confirmed at the time of arthroscopic synovectomy....
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000104842.97001.88
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to determine the relation among multiple morbidities and the prevalence of colorectal cancer (CRC) screening among older adult Appalachian residents of Kentucky. This is the first known study to address multiple morbidities exclusively with a health-disparities population. METH...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e31823a8879
更新日期:2011-12-01 00:00:00
abstract::We recently managed a patient with diabetic ketoacidosis who had an exceptionally high arterial oxygen tension of 144 mm Hg while breathing room air. This was higher than the calculated alveolar oxygen tension and suggested the impossible situation of an uphill diffusion gradient. We were surprised to find this is a r...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197909000-00013
更新日期:1979-09-01 00:00:00
abstract:OBJECTIVES:In this study, we determined patients' attitudes toward discussing firearms and issues of firearms safety with emergency department physicians. We assessed whether patients feel discriminated against should physicians discuss firearms safety, and whether they believed that physician counseling may change how...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000915
更新日期:2019-01-01 00:00:00
abstract::Presented in a case in which calcification of the adrenal gland was roentgenographically evident on the first day of life. The earliest previously reported case of adrenal calcification was at 8 days of age and was attributed to an intrapartum hemorrhage. It is proposed that an intrauterine third trimester insult was ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197903000-00045
更新日期:1979-03-01 00:00:00
abstract::A case of brain stem infarction after chiropractic manipulation of the cervical spine is presented. Proposed mechanisms and sites of possible arterial injury are discussed. A diagnosis of vertebral artery occlusion was made using conventional brachial angiography. Digital intravenous angiography, a relatively new and ...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198312000-00014
更新日期:1983-12-01 00:00:00
abstract::A "life stress" scale is applied to the antecedent events motivating 179 patients to seek outpatient psychiatric help. Intake evaluation reports of patients who kept their appointments at the Adult Psychiatric Outpatient Clinic of Vanderbilt University Hospital over a three-month period were reviewed. Almost half of t...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197602000-00016
更新日期:1976-02-01 00:00:00
abstract:BACKGROUND:Pneumonia is a leading infectious cause of morbidity and mortality in the United States. The Infectious Disease Society of America (IDSA) and American Thoracic Society (ATS) have published treatment guidelines for community-acquired pneumonia (CAP) based upon the site of acquisition and specific pathogen ris...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e318287fe71
更新日期:2013-03-01 00:00:00
abstract::Concurrent occurrence of carotid artery stenosis and intracerebral aneurysm is uncommon and poses a therapeutic dilemma. We report a patient with bilateral carotid artery stenosis and a 2.5 cm left middle cerebral artery aneurysm who simultaneously underwent a successful stent-assisted coiling for his intracerebral an...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000217190.93989.c9
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVES:To determine the comparative impact of the standard Parents as Teachers (PAT) to the nutrition and physical activity enhanced version (PATE) of the perinatal educational curriculum on compliance with infant feeding recommendations and changes in maternal infant feeding knowledge and beliefs. METHODS:Women a...
journal_title:Southern medical journal
pub_type: 杂志文章,随机对照试验
doi:10.14423/SMJ.0000000000001024
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) was investigated at a tertiary care hospital, and relationship was made between the clinical and genetic definitions of community- and healthcare-associated MRSA. METHODS:Nonduplicate isolates of S. aureus were collected during 2004. Iso...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e31815d3fce
更新日期:2008-01-01 00:00:00
abstract::Atypical facial pain or neuralgia and lower-half headache are confusing terms and should be discarded. Recurrent unilateral, throbbing, frontal headaches should be referred to as facial migraine. Patients whose trigeminal branches have been subjected to repeated surgical procedures and who have relentless unilateral f...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198207000-00012
更新日期:1982-07-01 00:00:00
abstract::We have described a patient who died of disseminated strongyloidiasis as a result of steroid therapy, despite an extensive diagnostic evaluation in the face of eosinophilia, but before any immunosuppressive therapy. This death might have been prevented by presumptive treatment after work-up but before immunosuppressiv...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198311000-00030
更新日期:1983-11-01 00:00:00
abstract::Septic arthritis is a serious and sometimes fatal complication of rheumatoid arthritis. We have examined the clinical characteristics of 16 patients with infectious arthritis seen during an eight-year period. This represented 0.5% of all admissions to our hospital for patients with rheumatoid arthritis. Although rheum...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198610000-00011
更新日期:1986-10-01 00:00:00
abstract::A variant of hereditary hemorrhagic telangiectasia may be gastrointestinal bleeding with no other classical symptoms. This case demonstrates the effectiveness of surgical resection as treatment of duodenal bleeding from telangiectatic lesions. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198703000-00024
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:Tobacco-growing states have few tobacco control laws, which are relatively weak compared with those in non-tobacco-growing states. Region of the country has been shown to be a predictor of legislators' intentions to vote for cigarette tax increases. METHODS:A total of 116 lawmakers (84%) participated in fac...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract::The correct diagnosis of benign hyperthyroxinemia in this patient and his family members will spare them the unnecessary testing and treatment for thyrotoxicosis that has befallen some such patients. Results of the usual blood tests for assessment of thyroid function, such as T4, T3, and thyrotropin determinations, we...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198903000-00022
更新日期:1989-03-01 00:00:00
abstract::Implantation of automatic internal cardiac defibrillators (AICD) for management of arrhythmias necessitates the induction of ventricular fibrillation (VF) to test the device adequately. The profound hypotension associated with induced arrhythmia and subsequent circulatory arrest may result in cerebral ischemia. To cha...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199305000-00009
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVES:Anemia, either chronic or newly developed in the hospital as a result of underlying disease and/or phlebotomy, is seen commonly among general medical inpatients, and its impact on the quality and efficiency of care is unknown. METHODS:This study investigated the relation among hemoglobin level, length of st...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e318290f930
更新日期:2013-05-01 00:00:00
abstract::We have described a class 4 choledochal cyst in a 24-year-old black woman treated with choledochocystoduodenostomy. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198605000-00034
更新日期:1986-05-01 00:00:00
abstract::We have described a case in which the diagnosis of multiple sclerosis with findings of progressive paraplegia and a neurogenic bladder led to supravesical urinary diversion. Pyocystis led to creation of a urethrovesicovaginal fistula. Psychotherapy later uncovered hysterical conversion reaction. Which was cured with h...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198109000-00039
更新日期:1981-09-01 00:00:00
abstract::We have reported a case of spontaneous dissection of the internal carotid artery, with MRI and angiographic findings. We conclude that MRI is a beneficial noninvasive test for the detection and study of carotid artery dissection. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199109000-00021
更新日期:1991-09-01 00:00:00
abstract::Narcolepsy is a severely debilitating neurologic disease that is not as rare as many believe, affecting an estimated 140,000 Americans. Despite the sometimes debilitating nature of narcolepsy symptoms, the disease may go undiagnosed without an organized method for evaluating patients with sleep complaints. Many of the...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/01.smj.0000056655.15660.42
更新日期:2003-03-01 00:00:00