Staphylococcal wound infection in the pig: Part I. Course.

Abstract:

:Full-thickness excision wounds infected with Staphylococcus hyicus, a pig pathogen, or Staphylococcus aureus, a human pathogen, were produced in pigs. The inoculated wounds were kept occluded for 2 days and then exposed and biopsied at intervals for 9 to 12 days. The exposed lesions were edematous and exudative. The S. aureus model was experimentally advantageous because the infection remained localized to the wound without systemic infection or signs of discomfort. The S. hyicus infection caused a rash with skin blisters; thus, its use is discouraged. The concentration of S. hyicus in the wound on day 2 was log 8.6 +/- 0.4 CFU/g (mean +/- standard deviation). On day 4 the mean was log 9.2. For S. aureus the values were log 8.0 +/- 0.9 on day 2 and 6.9 on day 4 (p less than 0.05). Of the 50 individual values in the S. aureus series, 45 were above log 5. The inflammatory reaction was more pronounced after the infection with S. hyicus, whereas with S. aureus the fibroblast response came earlier and was more pronounced. The model parallels typical clinical courses of staphylococcal infection.

journal_name

Ann Plast Surg

authors

Svedman P,Ljungh A,Rausing A,Banck G,Sandén G,Miedzobrodzki J,Wadström T

doi

10.1097/00000637-198909000-00004

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

212-8

issue

3

eissn

0148-7043

issn

1536-3708

journal_volume

23

pub_type

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