Abstract:
:Several experimental studies have demonstrated that granulocytes have an important role in causing the necrosis of ischemic tissue by capillary plugging and superoxide radical formation. Adenosine is spontaneously released by ischemic cells and inhibits the granulocytic superoxide radical formation. 5-Aminoimidazole-4-carboxamide riboside, a naturally occurring by-product in purine biosynthesis, stimulates the release of ischemic cell adenosine and indirectly blocks the granulocyte-induced tissue necrosis. 5-Aminoimidazole-4-carboxamide riboside (10-500 mg/kg) was administered intraperitoneally in a blinded fashion once (single dose, 30 minutes before surgery) or twice (double dose, 30 minutes before and 5.5 hours after surgery) in groups of rats. The controls received intraperitoneal saline solution in the same fashion. Each rat underwent the elevation of a caudally based random skin flap. The flap viability was determined in a blinded fashion on the seventh post-operative day and statistically compared by Fisher's exact test. When 300 or 500 mg/kg of 5-aminoimidazole-4-carboxamide riboside was given as a single dose, the mean percentage of rat skin flap necrosis (19.4% +/- 3.1% and 19.6% +/- 4.2%, respectively) was lower but not significantly different from that of the control group of rats (29.3% +/- 2.7%) (p less than 0.08). Additionally, two doses of 500 mg/kg of 5-aminoimidazole-4-carboxamide riboside yielded a mean percentage of rat skin flap necrosis (12.24% +/- 4.58%) much lower (21.68% +/- 3.18%) than that of the control group of rats (p = 0.056). Our blinded fashion study demonstrated an almost statistically significant reduction of random skin flap distal necrosis after intraperitoneal injection of high doses of 5-aminoimidazole-4-carboxamide riboside.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Ann Plast Surgjournal_title
Annals of plastic surgeryauthors
Salerno GM,McBride DM,Bleicher JNdoi
10.1097/00000637-199106000-00008subject
Has Abstractpub_date
1991-06-01 00:00:00pages
544-50issue
6eissn
0148-7043issn
1536-3708journal_volume
26pub_type
杂志文章abstract::Exposure of silicone breast implants usually leads to infection and extrusion. According to the literature, implant extrusion rates are not higher than 2% 1 and removal of the implant is recommended. 2 During the past 3 years, the authors dealt with eight implant exposures (six women: two cases of bilateral exposure a...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.SAP.0000044251.40733.2B
更新日期:2003-05-01 00:00:00
abstract::A simple, efficient, yet expedient method producing an ideal stent has proved to be highly reliable in over 150 clinical cases. When performed technically correctly, 100% graft take may be anticipated under most grafting circumstances. The method uses Reston (3-M Company, St. Paul, MN), a synthetic urethane foam pad, ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198407000-00005
更新日期:1984-07-01 00:00:00
abstract::Nerve graft procedures require the use of a donor nerve to supply the graft material. This results in an area of numbness in a less critical region. The purpose of this study was to assess donor site recovery using patient subjective evaluation. Thirty-one patients (mean age, 38 years) who were at least 2 years past a...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199912000-00005
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Mesh infection after abdominal hernia repair is a devastating complication that affects general and plastic surgeons alike. The purpose of this study was 3-fold: (1) to determine current evidence for treatment of infected abdominal wall mesh via systematic review of literature, (2) to analyze our single-inst...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/SAP.0000000000001189
更新日期:2018-02-01 00:00:00
abstract::A 69-year-old woman with a history of mastectomy and radiotherapy for breast carcinoma demonstrated extensive anterior thoracic wall radionecrosis 22 years later. The latissimus dorsi musculocutaneous flap was chosen to repair two distant ulcerative defects. Chest wall coverage was performed by dividing the muscle int...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199410000-00011
更新日期:1994-10-01 00:00:00
abstract::The principles and techniques of gene transfer are presented. Common concepts are defined, and the frequently used transfer vectors are described herein. Several gene transfer applications are discussed briefly. Areas of particular interest to the plastic surgeon such as gene transfer to skin and wounds are included. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/00000637-199510000-00018
更新日期:1995-10-01 00:00:00
abstract::Currently, 50 cases of craniocarpotarsal dysplasia, or whistling face syndrome (WFS), have been reported, with more than 60 anatomical anomalies involving the head, hands, and feet, in addition to the face. In spite of the fact that there is much information concerning the surgical correction of many of these deformit...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::Five patients with avulsed scalps were treated with replantation between 1992 and 1998. All patients were women age 20 to 36 years. The percentage of the avulsed scalp ranged from 50% to 100% of the whole scalp. The vessels chosen for anastomosis were the superficial temporal artery, occipital artery, and superficial ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200044040-00002
更新日期:2000-04-01 00:00:00
abstract:ABSTRACT:The era of genetics and precision medicine has been reforming this world. How will plastic surgeons in the field of vascular anomalies conform to the trend? This article systematically reviews the identification of serum biomarkers, risk factors, specific mutations in the angiogenesis-related genes such as GNA...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002723
更新日期:2021-01-19 00:00:00
abstract::Based on our clinical experience, various methods of donor or recipient vascular pedicle coverage for an arterialized or free flap are reported. The vascular pedicle may be placed in the subcutaneous space either by incising the skin along the full length of the vascular route or by passing it through a subcutaneous t...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-197910000-00003
更新日期:1979-10-01 00:00:00
abstract::Over the past four years we have performed total phallic reconstructions in 12 patients. Six patients underwent reconstruction following trauma, 3 were female-to-male transsexuals, and 3 had micropenis deformities. These reconstructions were one-stage microsurgical tissue transfers that included urethral reconstructio...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198702000-00006
更新日期:1987-02-01 00:00:00
abstract::Previous work in our laboratory has indicated that ischemic preconditioning improves musculocutaneous flap survival 2.5 times that of the control flap area when the flaps are subsequently subjected to 4 hours of global ischemia. The preconditioning protocol used in this study was arbitrarily designed to be 10 minutes ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199804000-00018
更新日期:1998-04-01 00:00:00
abstract::Lymphaticovenular anastomosis has become one of the treatment options for lymphedema. Among several types of anastomosis, side-to-end anastomosis in which a window is made on the wall of a lymphatic vessel is considered to be the most effective, because it creates bidirectional bypasses through 1 anastomosis. However,...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318276d99a
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Changes in breast sensation after reconstruction are expected. Return of breast sensation after reconstruction and whether nipple-sparing mastectomy offers a substantial benefit in terms of sensation has been inconsistently documented in the literature. We conducted the current study using the pressure-speci...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000900
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:A novel coronavirus disease (COVID-19) was first reported in December 2019 in China and was soon declared a pandemic by the World Health Organization. Many elective and nonessential surgeries were postponed worldwide in an effort to minimize spread of disease, as well as to conserve resources. Our goal with ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002443
更新日期:2020-08-01 00:00:00
abstract::The split-thickness skin graft (STSG) donor sites have been treated with various and plenty of dressing techniques and materials. An ideal STSG donor site dressing should have antibacterial, hemostatic, and promoting epidermal healing properties. We have performed a prospective study to evaluate the effect of the oxid...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000208945.12083.59
更新日期:2006-07-01 00:00:00
abstract::Acquired digital fibrokeratomas are benign, rare tumors that develop most commonly on the fingers. They can have an appearance of a rudimentary supernumerary digit or be misdiagnosed as a more common condition, such as verruca vulgaris. There are no case reports described in the plastic surgery literature. We are repo...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3182996ee6
更新日期:2015-03-01 00:00:00
abstract::The first metatarsophalangeal joint area is a very difficult one to reconstruct, needing skin that is thick, sensitive, and resistant to friction. Although the medial plantar island flap was initially described to resurface heel defects, we have used this flap as a cross-foot flap to recover the first metatarsophalang...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198805000-00012
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:Hematomas after tissue expander immediate breast reconstruction (TE-IBR) pose a significant challenge during the recovery period. In this study, we aim to evaluate whether hematoma formation leads to subsequent complications and how management can impact final reconstructive goals. METHODS:A single-institut...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002343
更新日期:2020-07-01 00:00:00
abstract::Piezoelectric sensors have been shown to respond reproducibly to changes in tissue mechanical properties surrounding an implant over a 4-month period. The vibrational amplitude at a frequency corresponding to the radial resonance shows a statistically significant change over time. The initial period of inflammation is...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000189620.45708.5f
更新日期:2006-01-01 00:00:00
abstract::High velocity injuries have traditionally been covered with free muscle flaps. We sought to evaluate the utility of the anterolateral thigh flap (ALT) flap as a primary choice in reconstructing traumatic injuries in Western patients.A retrospective chart review was conducted of 122 patients treated at the R Adams Cowl...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3181a20ab0
更新日期:2010-02-01 00:00:00
abstract::An operation to correct "chubby" cheeks is described. The technique is simple and safe and gives predictable results. The buccal lipectomy may be performed by itself or as an adjunct to other facial cosmetic surgery. No permanent complications were experienced in 9 patients over a three and a half-year period. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198008000-00006
更新日期:1980-08-01 00:00:00
abstract::To reconstruct medial orbital wall fractures with a clear, least dissection, an alternative method, precaruncular approach, has been performed. We reviewed 36 patients with medial blowout fractures treated with this technique. The incision was made between the caruncle and medial canthal skin at the mucocutaneous junc...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31826a1a75
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The recent rise in medical tourism, especially for cosmetic procedures, has been mirrored by an increase in the incidence of infections with Mycobacterium abscessus, which is an atypical mycobacterium that is ubiquitous in aquatic environments. M. abscessus soft tissue infections arise from the use of improp...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002061
更新日期:2020-03-01 00:00:00
abstract::The purpose of this study was to investigate nose maturation by cephalometric sagittal surface area methodology longitudinally in males and females. Both males and females exhibited a statistically significant continuum of nose growth from ages 6 to 18. Growth ceased in both sexes at age 18. Correlation coefficients i...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198704000-00007
更新日期:1987-04-01 00:00:00
abstract::A chronic ulcer of the posterior heel or lateral ankle can be a large problem for the patient. The lateral calcaneal artery flap is a reliable neurovascular local skin flap that can cover the defect after excision of the ulcer in this area. The flap includes the lateral calcaneal artery, sural nerve, and lesser saphen...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198812000-00007
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND:Human cadaveric skin grafts are considered as the "gold standard" for temporary wound coverage because they provide a more conductive environment for natural wound healing. Lyophilization, packing, and terminal sterilization with gamma-ray can facilitate the application of cadaveric split-thickness skin graf...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001019
更新日期:2017-03-01 00:00:00
abstract::Thirteen breast reconstructions in 11 patients, averaging 58 years of age, underwent mastectomies. The technique uses a saline implant either totally or partially covered with a human acellular dermal matrix. The mean postoperative follow-up time was 14 months. Ninety percent of the patients were considered high risk;...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000185460.31188.c1
更新日期:2006-01-01 00:00:00
abstract::Nasolabial flaps are frequently used for reconstruction of nasal and midfacial defects. The donor site and the quality of the skin provided are excellent, though reconstructive results are sometimes hampered by a dog-ear at the base of the flap. Properly designed rhomboid flaps generally rotate into position without a...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199209000-00015
更新日期:1992-09-01 00:00:00
abstract::The purpose of this study is to objectively evaluate donor-site morbidity of the inferior gluteal musculocutaneous flap in teenagers. All cases of breast reconstruction performed between 1996 and 2005 using an inferior gluteal flap were reviewed. Flap size, weight, and pedicle origin were noted. Donor-site morbidity w...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000259595.65804.2f
更新日期:2007-12-01 00:00:00