MicroRNA signatures in ischemia-reperfusion injury.

Abstract:

BACKGROUND:MicroRNAs (miRs) are involved in gene expression and function, but little is known of their function in ischemia-reperfusion injury (IRI), which plays a critical role in flap compromise during microvascular flap surgeries. This article aimed to determine the expression profiles of miRs in rat flap surgeries after IRI. METHODS:Vessel specimens in rat epigastric flap were initially determined for miRs survey after 2 hours of ischemia and 2 hours of reperfusion. Their miR expressions were further quantified after 2 hours of ischemia and subsequent reperfusion for 2 and 24 hours. RESULTS:Only 3 miRs (miR-21, miR-193-3p, and miR-210) in rat vessels, but not in flap tissues, were significantly up-regulated at 24 hours of reperfusion after 2 hours of ischemia. CONCLUSIONS:Our findings provide insights into deregulated expressions of miRs in flap surgeries after IRI. They might provide a further therapeutic consideration to prevent vascular compromise due to IRI in flap surgeries.

journal_name

Ann Plast Surg

authors

Chang KP,Lee HC,Huang SH,Lee SS,Lai CS,Lin SD

doi

10.1097/SAP.0b013e3182742c45

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

668-71

issue

6

eissn

0148-7043

issn

1536-3708

pii

00000637-201212000-00016

journal_volume

69

pub_type

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