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Pregnancy outcome following hematopoietic cell transplantation for thalassemia major.

Abstract：

:The aim of this study was to investigate the methods of conception and delivery, as well as the course and outcome of 42 pregnancies occurring in 15 female patients (27 pregnancies) and partners of 8 male patients (15 pregnancies) with β-thalassemia major who were successfully treated with allogeneic hematopoietic cell transplantation (HCT). Most pregnancies (n=21) were achieved with spontaneous conception in female patients. There were two miscarriages. Five pregnancies were late preterm. Delivery was vaginal in 4 cases and by caesarean section in 18. Overall, 22 term pregnancies resulted in successful deliveries of 23 neonates. Two of 23 neonates were symmetrical small for gestational age / intrauterine growth restriction. All 15 pregnancies that occurred in partners of men who received an allogeneic HCT were achieved with spontaneous conception. No miscarriage was observed. Overall, 14 term pregnancies resulted in successful deliveries of 14 live-born singletons. Delivery was vaginal in nine cases and by caesarean section in five. All infants were full-term. Many patients with β-thalassemia major who received an allogeneic HCT retained or recovered their fertility after transplant. In these patients, pregnancy has been a practical and safe possibility and usually had a favorable outcome as in the normal population.

journal_name

Bone Marrow Transplant

journal_title

Bone marrow transplantation

authors

Santarone S,Natale A,Olioso P,Onofrillo D,D'Incecco C,Parruti G,Di Bartolomeo P

doi

10.1038/bmt.2016.287

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

388-393

issue

3

eissn

0268-3369

issn

1476-5365

pii

bmt2016287

journal_volume

52

pub_type

临床试验,杂志文章

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