Abstract:
PURPOSE:Feeding and systemic hypoxia are major stresses inducing necrotizing enterocolitis (NEC). This study aims to investigate the role of systemic hypoxia in NEC and its effect before and after feeding. METHODS:Neonatal mice were studied in three groups. Control (N = 9): breast feeding; NEC A (N = 8), gavage feeding + lipopolysaccharide (LPS) + preprandial hypoxia; and NEC B (N = 9), feeding + LPS + postprandial hypoxia. Pimonidazole, a hypoxia marker, was injected intraperitoneally before ileum was harvested for histology and quantitative RT-PCR studies. Statistical analysis was done using the ANOVA and Chi-square test. RESULTS:NEC incidence was 62.5% in NEC A and 88.9% in NEC B. The mortality in NEC B (55.6%) but not A (25%) is significantly higher than control (0%, p < 0.05). Pimonidazole staining elevated in both NEC A and B with higher pimonidazole grade in NEC B (p < 0.01). Both NEC groups had increased the expression of hypoxia-related genes: HIF-1α, GLUT-1, and PHD-3 with GLUT-1 expressed more in NEC B compared with NEC A (p < 0.01). The inflammation marker, IL6, was similarly raised in both NEC A and B. CONCLUSION:Feeding and postprandial hypoxia synergistically induce intestinal hypoxia in NEC. As feeding increases intestinal oxygen demand, maintaining a balance between intestinal oxygen supply and demand is important to prevent NEC.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Chen Y,Koike Y,Miyake H,Li B,Lee C,Hock A,Zani A,Pierro Adoi
10.1007/s00383-016-3997-8subject
Has Abstractpub_date
2016-12-01 00:00:00pages
1115-1119issue
12eissn
0179-0358issn
1437-9813pii
10.1007/s00383-016-3997-8journal_volume
32pub_type
杂志文章abstract::Congenital diaphragmatic hernia (CDH) is accompanied by pulmonary hypoplasia and pulmonary hypertension. Fetal lung growth is dependent on the secretion of lung liquid, which normally is absorbed at partus. The ion channel NKCC-1 is involved in this secretory process, but has recently also been reported to be implicat...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-008-2209-6
更新日期:2008-09-01 00:00:00
abstract:AIM:An experimental study was performed to investigate the efficacy of colchicine in the prevention of fibrosis in the alkaline burn of the esophagus in rats. METHOD:A standard esophageal alkaline burn was produced by the application of 37.5% NaOH for a period of 90 s to the distal esophagus followed by a water rinse....
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-006-1644-5
更新日期:2006-04-01 00:00:00
abstract::An infant with a large-bowel obstruction due to Salmonella B enterocolitis is presented. The clinical and radiologic findings were suggestive of Hirschsprung's disease with total colonic aganglionosis. Due to further deterioration, an ileostomy was performed. Pathologic examination disclosed ganglia in the colon. At l...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003839900332
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abstract::We report the case of a female adolescent who had an ectopic ovary in the inguinal canal without an associated hernia, a unicornuate uterus, and ipsilateral renal agenesis. The incidental discovery of the ectopic ovary and other Mullerian anomalies, as well as the surgical correction that followed, highlights importan...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-014-3582-y
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:Determining the integrity of the pancreatic duct is important in high-grade pancreatic trauma to guide decision making for operative vs non-operative management. Computed tomography (CT) is generally an inadequate study for this purpose, and magnetic resonance cholangiopancreatography (MRCP) is sometimes obtain...
journal_title:Pediatric surgery international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00383-018-4309-2
更新日期:2018-09-01 00:00:00
abstract::Pediatric vascular injuries are increasing in frequency and represent a challenging problem in pediatric surgical practice. Increased survival of low birth weight infants and advances in invasive diagnostic procedures have resulted in a dramatic increase in the number of these injuries. Formation of pseudoaneurysm of ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-004-1238-z
更新日期:2004-08-01 00:00:00
abstract::Gastroesophageal reflux (GER) is common after repair of esophageal atresia with a distal tracheoesophageal fistula (EATOF). In a retrospective study we assessed whether early 18-h pH monitoring can predict the development of EATOF-associated gastroesophageal reflux. During 1980-1997, 90 consecutive patients had primar...
journal_title:Pediatric surgery international
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更新日期:2004-09-01 00:00:00
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journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830000531
更新日期:2001-07-01 00:00:00
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journal_title:Pediatric surgery international
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journal_title:Pediatric surgery international
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更新日期:2004-03-01 00:00:00
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journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-014-3509-7
更新日期:2014-06-01 00:00:00
abstract::High ligation of spermatic vessels (HLSV) and low ligation of spermatic vessels (LLSV) have been described in the surgical treatment of high undescended testis. Testicular capillary blood flow utilizing laser Doppler flowmetry after these maneuvers has not been studied thus far; hence, this study was designed. Thirty ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-003-1018-1
更新日期:2003-07-01 00:00:00
abstract::Thyroglossal duct cysts are one of the most commonly encountered benign neck lumps found in the paediatric population. Despite their relative frequency, reports of familial inheritance are rare. A total of 21 patients with hereditary thyroglossal duct cysts from seven families worldwide have been reported. The most co...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-005-1420-y
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journal_title:Pediatric surgery international
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doi:10.1007/s00383-009-2361-7
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abstract::A rare case of congenital duodenal atresia (DA) associated with a choledochal cyst (CC) is reported. At 38 weeks of gestation, a 1,610-g girl was born by cesarean section with a prenatal diagnosis of DA. After the disorder was confirmed by X-ray, she underwent a duodenoduodenostomy for a complete separation of the duo...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830100703
更新日期:2002-05-01 00:00:00
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journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-015-3749-1
更新日期:2015-09-01 00:00:00
abstract::The most popular techniques for repairing large diaphragmatic defects involve the use of synthetic patches. We present an alternative approach using living tissue. We reviewed our cases of congenital diaphragmatic hernia (CDH) diagnosed within the first 24 h of life from 1991 to 2003. Toldt's fascia (TF) flap was used...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-004-1267-7
更新日期:2005-01-01 00:00:00
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journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-002-0931-z
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journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-007-1957-z
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journal_title:Pediatric surgery international
pub_type: 杂志文章,随机对照试验
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更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Necrotizing enterocolitis (NEC) is a gastrointestinal disease of complex etiology resulting in devastating systemic inflammation and often death in premature newborns. We previously demonstrated that formula feeding inhibits ileal expression of heat shock protein-70 (Hsp70), a critical stress protein within ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:Pediatric surgery international
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更新日期:2003-05-01 00:00:00
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journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-005-1534-2
更新日期:2005-09-01 00:00:00
abstract::The intrinsic innervation of the developing gut has long been a subject of investigation, but little is known regarding that of the embryonic cloaca. The cloaca, like the rest of the gastrointestinal tract, is intrinsically innervated by the enteric nervous system. Nitrergic neurons and fibres make up a large part of ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-005-1590-7
更新日期:2006-01-01 00:00:00
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journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-003-0970-0
更新日期:2003-11-01 00:00:00
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journal_title:Pediatric surgery international
pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF00626057
更新日期:1996-10-01 00:00:00
abstract::Colonic atresia and choledochal cyst are rare congenital abnormalities and there are few cases of their coexistence reported in the literature. We report a case of choledochal cyst and colonic atresia in a term neonate. Our prenatal ultrasonographic and intraoperative findings support the idea that these two entities ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-008-2280-z
更新日期:2009-01-01 00:00:00