Abstract：
:The intrinsic innervation of the developing gut has long been a subject of investigation, but little is known regarding that of the embryonic cloaca. The cloaca, like the rest of the gastrointestinal tract, is intrinsically innervated by the enteric nervous system. Nitrergic neurons and fibres make up a large part of this system, thus, their distribution provides us with a useful insight into its development. Cloacal and colorectal tissue specimens were removed from chick embryos at embryonic days 11 (E11), E15 and E19. NADPH-diaphorase (NADPH-d) histochemistry was carried out using whole mount tissue preparations. Ganglia density, the number of NADPH-d-positive cells per ganglia in the myenteric plexus and cell size were calculated and statistical analysis was performed to compare both regions of the gut (P<0.001). There were significant differences in the ganglia density in the cloaca compared to the colorectum at E11 (P<0.05) and E15 (P<0.01), with the colorectum having a much denser network. In both the cloaca and the colorectum, ganglia density significantly decreased with age (P<0.001), while significant differences were observed in the number of NADPH-d-positive cells per ganglia in both regions through development. Total cell size was similar in both the cloaca and colorectum at each stage and increased in both regions through development, predominantly due to an increase in the cytoplasm. Results reveal striking differences in innervation between the chick embryo cloaca and colorectum. The sparse network of innervation evident within the cloaca in contrast to the dense network within the colorectum emphasizes the individuality of both regions. These results highlight the need for a further in-depth analysis of the enteric nervous system's development within the embryonic cloaca.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
O'Donnell AM,Bannigan J,Puri Pdoi
10.1007/s00383-005-1590-7subject
Has Abstractpub_date
2006-01-01 00:00:00pages
90-4issue
1eissn
0179-0358issn
1437-9813journal_volume
22pub_type
杂志文章abstract：OBJECTIVE:Several procedures have been described for repair of distal hypospadias. However, these are not without any complications. Corpus spongiosum advancement is a new technique employed in our patients for distal hypospadias repair with excellent clinical outcome and no post-operative complications. PATIENTS AND ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-013-3292-x
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:Necrotizing enterocolitis (NEC) is a gastrointestinal disease of complex etiology resulting in devastating systemic inflammation and often death in premature newborns. We previously demonstrated that formula feeding inhibits ileal expression of heat shock protein-70 (Hsp70), a critical stress protein within ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-017-4211-3
更新日期：2018-03-01 00:00:00
abstract：:Thyroglossal duct cysts are one of the most commonly encountered benign neck lumps found in the paediatric population. Despite their relative frequency, reports of familial inheritance are rare. A total of 21 patients with hereditary thyroglossal duct cysts from seven families worldwide have been reported. The most co...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-005-1420-y
更新日期：2005-07-01 00:00:00
abstract：:It has been assumed that only 10% of medical interventions are supported by solid scientific evidence. The aim of this study was to determine the type of research evidence supporting operations in a tertiary referral paediatric surgical unit. All patients admitted over a 4-week period to two surgical firms were enroll...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050332
更新日期：1998-07-01 00:00:00
abstract：:Rhizomelic chondrodysplasia punctata (RCP), a rare autosomal recessive disease characterized by a disorder of peroxisome metabolism, has been shown to affect multiple organ systems. A neonate presenting with a colonic perforation in the first few hours of life was subsequently diagnosed with RCP. A literature search r...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-005-1426-5
更新日期：2005-08-01 00:00:00
abstract：:Various options are available for the surgical treatment of meconium ileus (MI). This paper examines the use of resection and primary anastomosis as the favoured option for the treatment of complicated meconium ileus. This was a retrospective study. All patients (13 children) with MI treated with primary resection and...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-007-2020-9
更新日期：2007-11-01 00:00:00
abstract：:To categorize variant persistent müllerian-duct derivatives (MDD) in males and determine their related clinical presentations for further management, five male patients with retained MDDs from abnormal müllerian remnants were studied. They comprised one patient with persistent müllerian-duct syndrome, one with transve...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0718-2
更新日期：2002-09-01 00:00:00
abstract：BACKGROUND:The high mortality rate in congenital diaphragmatic hernia (CDH) is attributed to pulmonary hypoplasia (PH). Insulin-like growth factor 2 (IGF2) is an important regulator of fetal growth. The highest levels of IGF2 expression are found in the placenta, which are negatively regulated by decidual retinoid acid...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-013-3449-7
更新日期：2014-02-01 00:00:00
abstract：PURPOSE:The use of general anesthesia in young children has come under increasing scrutiny due to its potential long-term neurotoxic effects. Meanwhile, regional anesthesia for surgical procedures in neonates has many advantages, including preservation of respiratory status and faster return to feeding. We describe the...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-016-4027-6
更新日期：2017-03-01 00:00:00
abstract：PURPOSE:The surgical treatment of children with H-fistula is one of the understudied problems of the present day, especially regarding its high rates of complications. The surgical technique of bringing down the anterior wall of rectum in clinical practice allows us in reducing the rate of H-fistula recurrences. The re...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-008-2234-5
更新日期：2008-11-01 00:00:00
abstract：PURPOSE:The aim of this study was to determine if the placement of prophylactic drains influences the incidence of postoperative adverse events in neonates. METHODS:Neonatal patients undergoing laparotomy between April 2000 and December 2007 were prospectively assigned to aggressive peritoneal cavity lavage, without t...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-011-2905-5
更新日期：2011-09-01 00:00:00
abstract：:Rhabdoid tumour of the kidney is not common. Presentation of such a lethal tumour along with blunt abdominal trauma is even rarer. We report such a case of Rhabdoid tumour of kidney which presented as renal trauma, and discuss the diagnostic difficulties and rapidly fatal outcome. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003839900290
更新日期：2000-01-01 00:00:00
abstract：:The presentation of congenital diaphragmatic hernia (CDH) at birth may fall outside the typical features (cyanosis, tachypnea and respiratory failure), manifesting, instead, also with others pictures that make the diagnosis difficult or even impossible. We report a case of CDH presenting as a pneumothorax and a perfor...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-007-2000-0
更新日期：2008-03-01 00:00:00
abstract：:To assess the relation between continence and the manometric and endosonographic state of the anorectal segment after surgery for anorectal anomalies (ARA), 33 adolescents operated upon for ARA and 14 controls were examined. Seventeen patients had low and 16 intermediate or high ARA. Fecal continence was recorded, and...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF01258715
更新日期：1997-09-01 00:00:00
abstract：:The purpose of this report was to analyze the patients requiring preoperative extracorporeal membrane oxygenation (ECMO) as the most critical group of patients with congenital diaphragmatic hernia (CDH) and to identify any special features. Over the past 11 years, out of 72 neonates with CDH admitted before 24 h of ag...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050428
更新日期：1998-11-01 00:00:00
abstract：:The aim of this study was to assess the feasibility of complex minimally invasive surgery in neonates (and infants <5 kg). A systematic search of databases was performed. Inguinal herniotomy and pyloromyotomy were specifically excluded. Various operations were assessed for operative times, conversion rates, complicati...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-008-2318-2
更新日期：2009-03-01 00:00:00
abstract：AIM:In chick embryos, administration of cadmium (Cd) induces ventral body wall defects (VBWD) similar to human omphalocele. It has been shown that failure of proper VBW formation may be due to disruption of somite development during early embryogenesis. In the VBWD chick model, Cd causes abnormal cell death in the somi...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-012-3202-7
更新日期：2013-01-01 00:00:00
abstract：:Bronchogenic cyst (BC), which develops from abnormal budding of the tracheal diverticulum or ventral foregut, is a congenital bronchopulmonary malformation. Localization of the BC varies depending on the level of the abnormal budding. Thoracic or abdominal-sited diaphragmatic lesions are the rarest presentations of th...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-008-2187-8
更新日期：2008-08-01 00:00:00
abstract：:In children with severe chronic constipation, abnormal distribution of substance P (SP) and vasoactive intestinal peptide (VIP), which represent excitatory and inhibitory nerves, respectively, has been reported. The normal distribution of these neuropeptides, however, is not well known. The aim of this study was to de...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050438
更新日期：1998-11-01 00:00:00
abstract：:Pediatric germ cell tumors comprise 1-3% of all malignant pediatric tumors and are found in variable locations. We present the case of a term 3.7 kg neonate who was found to have a giant liver mass at birth, later determined to be an immature teratoma arising from the hepatoduodenal ligament. This case report and imag...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-017-4123-2
更新日期：2017-09-01 00:00:00
abstract：:Antral web is a rare cause of gastric-outlet obstruction. We report a case of gastric antral web with intermittent vomiting in a 10-year-old girl who received medical treatment for 6 months. The literature on this anomaly is reviewed with respect to differential diagnosis on the basis of upper gastrointestinal radiogr...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003839900317
更新日期：2000-01-01 00:00:00
abstract：AIM:The aim of our study is to introduce a new objective method of perioperative evaluation of the size of diaphragmatic defect to enable comparison of results among various centres and methods used for diaphragmatic reconstruction. MATERIALS AND METHODS:Prospective observational study of neonates with congenital diap...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-012-3113-7
更新日期：2012-10-01 00:00:00
abstract：:Extensive loss of small bowel in all age groups has significant morbidity and mortality consequences. Despite the astonishing ability of the small bowel to compensate for an extensive loss, long-term parenteral nutrition and enteral nutrition, tailored to the need of the patients in relation to the missing intestinal ...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-016-4043-6
更新日期：2017-04-01 00:00:00
abstract：:We present a neonate with gastroschisis and evidence of bile aspiration in utero, who developed severe respiratory distress that did not respond to postnatal intensive respiratory care. Although rare, a newborn with gastroschisis may develop severe respiratory distress due to bile aspiration in utero. Given the poor o...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-008-2223-8
更新日期：2008-10-01 00:00:00
abstract：:The advances in science have resulted in the emergence of nanotechnology, which deals with the design and use of tools and devices of size 1-100 nm. The application of nanotechnologies to medicine is thus termed nanomedicine. Significant research has been focused on this new and exciting field and this review article ...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-012-3162-y
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:To review the effectiveness of the longitudinal intestinal lengthening and tailoring (LILT) and serial transverse enteroplasty (STEP) operations in a cohort of patients with short bowel syndrome (SBS). METHODS:We conducted a retrospective analysis of children with SBS treated at our institution from 2004 until...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-019-04468-3
更新日期：2019-06-01 00:00:00
abstract：:Pediatric vascular injuries are increasing in frequency and represent a challenging problem in pediatric surgical practice. Increased survival of low birth weight infants and advances in invasive diagnostic procedures have resulted in a dramatic increase in the number of these injuries. Formation of pseudoaneurysm of ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1238-z
更新日期：2004-08-01 00:00:00
abstract：PURPOSE:The need for clinically applicable skin substitutes continues to be a matter of fact. Hypothetically, a laboratory grown autologous skin analog with near normal architecture might be a suitable approach to yield both satisfactory functional and cosmetic long-term results. In this study, we explored the use of h...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3808-7
更新日期：2016-01-01 00:00:00
abstract：PURPOSE:Biliary atresia (BA) is characterized by progressive inflammation of the biliary system. This inflammation persists and causes liver fibrosis, although jaundice disappears after Kasai portoenterostomy (KP). We aimed to confirm whether the oral administration of eicosapentaenoic acid (EPA) suppresses liver fibro...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4313-6
更新日期：2018-10-01 00:00:00
abstract：:We present the first two cases of acute neonatal appendicitis operated on through the laparoscopic approach. Acute neonatal appendicitis is uncommon and rarely considered by clinicians when assessing the neonatal acute abdomen. Our two cases demonstrate the potential value of diagnostic laparoscopy in the acute neonat...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-011-2972-7
更新日期：2011-11-01 00:00:00
