当前位置： SCI文献检索 > UROLOGY期刊下所有文献 > TOP2A, HELLS, ATAD2, and TET3 Are Novel Prognostic Markers in Renal Cell Carcinoma.

TOP2A, HELLS, ATAD2, and TET3 Are Novel Prognostic Markers in Renal Cell Carcinoma.

Abstract：

OBJECTIVE:To identify and validate novel prognostic marker genes in clear cell renal cell carcinoma (RCC) that are increasingly expressed during tumor progression. METHODS:Total RNA was isolated from normal renal tissue, primary G1 and G3 tumors, 14 samples each, and 32 metastases from RCC patients. Expression profiles were created using oligonucleotide microarrays. Significant gene expression differences (P < .05) were identified among normal kidney, primary tumor, and metastases. For all filtered genes, univariate survival analysis was carried out. Genes for which lower expression was significantly associated with longer survival were further analyzed using multivariate analysis. Expression of the best candidate markers was further validated in an independent cohort of 55 primary tumors using quantitative real-time polymerase chain reaction. RESULTS:Fifty-nine genes exhibited increased expression in primary RCC compared with normal kidney, and in metastases compared with primary tumors. In univariate or multivariate survival analysis, upregulation of 15 genes was significant. Expression of 8 genes was validated by quantitative real-time polymerase chain reaction. Survival analysis in an independent cohort of 55 RCC patients based on expression in primary RCC showed that TOP2A (hazard ratio [HR] = 4.3, P = .005), HELLS (HR = 3.7, P = .007), ATAD2 (HR = 3.7, P = .019), and TET3 (HR = 2.8, P = .035) represent independent predictors for cancer-specific survival. The proteins encoded by these genes function as topoisomerase, helicase, chromatin modifier, and methyl cytosine dioxygenase, respectively. They are involved in proliferation, transcription, and epigenetic modification. CONCLUSION:High mRNA levels of TOP2A, HELLS, ATAD2, and TET3 are independent predictors of poor outcome in RCC patients and may be used for individual risk-adapted therapy in the future.

journal_name

Urology

journal_title

Urology

authors

Chen D,Maruschke M,Hakenberg O,Zimmermann W,Stief CG,Buchner A

doi

10.1016/j.urology.2016.12.050

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

265.e1-265.e7

eissn

0090-4295

issn

1527-9995

pii

S0090-4295(17)30006-7

journal_volume

102

pub_type

杂志文章

相关文献

UROLOGY文献大全
  • Megalourethra.

    abstract：:Two cases of megalourethra are presented, the ninth and tenth cases to be documented in the literature. Both patients exhibited mesodermal abnormalities which justify categorization among the minor forms of prune belly syndrome. One patient, the youngest to have undergone surgical correction, presented with azotemia, ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(78)90366-7

    authors： Lockhart JL,Reeve HR,Krueger RP,Glenn JF,Henry HH 2nd

    更新日期：1978-07-01 00:00:00

  • The case for primary endoscopic management of upper urinary tract calculi: II. Cost and outcome assessment of 112 primary ureteral calculi.

    abstract：OBJECTIVES:To compare extracorporeal shock-wave lithotripsy (ESWL) with endoscopic lithotripsy to establish the more efficacious and cost-effective treatment for ureteral calculi. METHODS:The records of 112 patients with primary ureteral calculi treated at one center with either ESWL or endoscopic lithotripsy were ret...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/S0090-4295(99)80003-X

    authors： Grasso M,Beaghler M,Loisides P

    更新日期：1995-03-01 00:00:00

  • Urethral Reconstruction in Aging Male Patients.

    abstract：OBJECTIVE:To report stricture characteristics, complications, and treatment outcomes among elderly men undergoing urethral reconstruction. MATERIALS AND METHODS:A retrospective review of urethroplasty cases and outcomes by a single surgeon from 2007 to 2014 was performed. Men were stratified by decade of life at time ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2017.09.029

    authors： Viers BR,Pagliara TJ,Rew CA,Folgosa-Cooley L,Shiang CY,Scott JM,Morey AF

    更新日期：2018-03-01 00:00:00

  • Lomefloxacin prophylaxis in visual laser ablation of the prostate.

    abstract：OBJECTIVES:Visual laser ablation of the prostate (VLAP) is a relatively new option for relief of urinary outlet obstruction secondary to benign prostatic hyperplasia. There is currently no consensus regarding the optimum use of antibiotic prophylaxis in VLAP. This study was designed to evaluate two dosage regimens of a...

    journal_title：Urology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0090-4295(94)80189-4

    authors： Costa FJ

    更新日期：1994-12-01 00:00:00

  • Effect of caffeine on urethral pressure.

    abstract：:Urethral pressure profiles have been a useful adjunct in the study of continence. Caffeine, a known smooth muscle inhibitor and skeletal muscle stimulator, is shown to decrease the urethral pressure profile in anesthetized dogs. This would lead one to believe that the smooth muscle component of urethral tonus is the d...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(77)90159-5

    authors： Palermo LM,Zimskind PD

    更新日期：1977-10-01 00:00:00

  • Selenium levels of patients with newly diagnosed prostate cancer compared with control group.

    abstract：OBJECTIVES:To compare the toenail selenium level of patients with prostate cancer with that of controls. A tumor-protective effect of selenium has been discussed for many years. Published data about the influence of the selenium level in the plasma and toenails are controversial. METHODS:Our prospective study included...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2003.12.028

    authors： Lipsky K,Zigeuner R,Zischka M,Schips L,Pummer K,Rehak P,Hubmer G

    更新日期：2004-05-01 00:00:00

  • S100A3 suppression inhibits in vitro and in vivo tumor growth and invasion of human castration-resistant prostate cancer cells.

    abstract：OBJECTIVE:To investigate the role of S100A3 and the effect of S100A3 inhibition on human castration-resistant prostate cancer (CRPC) cells by using in vitro and in vivo functional assays. MATERIALS AND METHODS:Using human CRPC cells (PC3 and DU145), S100A3 expression levels were assessed by reverse transcription-polym...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2014.09.018

    authors： Kang M,Lee HS,Lee YJ,Choi WS,Park YH,Jeong CW,Ku JH,Kim HH,Kwak C

    更新日期：2015-01-01 00:00:00

  • Deep lateral transurethral incisions for recurrent bladder neck contracture: promising 5-year experience using a standardized approach.

    abstract：OBJECTIVE:To evaluate our 5-year experience with deep lateral transurethral incisions of bladder neck contracture (TUIBNC), identify risk factors associated with failure of procedure, and assess outcomes of men subsequently treated for concomitant or de novo stress urinary incontinence (SUI). MATERIALS AND METHODS:We ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2013.08.018

    authors： Ramirez D,Zhao LC,Bagrodia A,Scott JF,Hudak SJ,Morey AF

    更新日期：2013-12-01 00:00:00

  • Chemoradiotherapy-induced Cytodifferentiation in Bladder/Prostate Rhabdomyosarcoma With Genetic Downregulation of Myogenin and MyoD1 Gene Expression: A Case Study and Review of the Literature.

    abstract：:Rhabdomyosarcoma is the most common sarcoma diagnosed in childhood and adolescence, arising from the bladder/prostate in only 5%-10% of cases. Treatment-induced cytodifferention of tumor cells into mature rhabdomyoblasts has been reported following chemoradiation and is thought to suggest a more favorable outcome. We ...

    journal_title：Urology

    pub_type：

    doi：10.1016/j.urology.2019.11.050

    authors： Agard H,Clark C,Massanyi E,Steele M,McMahon D

    更新日期：2020-03-01 00:00:00

  • Reliability of voiding cystourethrography to detect urethral obstruction in boys.

    abstract：OBJECTIVES:To evaluate the reliability of voiding cystourethrography (VCUG) to diagnose infravesical obstruction in boys. METHODS:Hard copies of the VCUG findings of 72 boys were assessed by two pediatric radiologists and two pediatric urologists. The investigators were instructed to consider six items related to infr...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2003.11.047

    authors： de Kort LM,Uiterwaal CS,Beek EJ,Jan Nievelstein RA,Klijn AJ,de Jong TP

    更新日期：2004-05-01 00:00:00

  • Treatment options for patients with stage D1 (T0-3,N1-2,M0) adenocarcinoma of prostate.

    abstract：:Three hundred six patients with adenocarcinoma of the prostate underwent pelvic lymphadenectomy and had Stage D1 (T0-3,N1-2,M0) disease; 171 patients underwent radical retropubic prostatectomy with or without immediate adjuvant therapy (hormonal or radiation or both) or conservative (hormonal or radiation or both) tre...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(87)90290-1

    authors： Zincke H,Utz DC,Thulé PM,Taylor WF

    更新日期：1987-10-01 00:00:00

  • Loss of expression of von Hippel-Lindau tumor suppressor protein associated with improved survival in patients with early-stage clear cell renal cell carcinoma.

    abstract：OBJECTIVES:To determine whether actual expression of the von Hippel-Lindau (VHL) protein product itself (pVHL) is associated with clear cell renal cell carcinoma (CC-RCC) survival. Recent data have suggested that somatic mutations of the VHL tumor suppressor gene are associated with better cancer-specific survival in p...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2004.12.040

    authors： Parker AS,Cheville JC,Lohse CM,Igel T,Leibovich BC,Blute ML

    更新日期：2005-06-01 00:00:00

  • Effect of sexually transmitted infections, lifetime sexual partner count, and recreational drug use on lower urinary tract symptoms in men who have sex with men.

    abstract：OBJECTIVE:To investigate the relationship of lower urinary tract symptoms (LUTS) to urinary tract infection, prostatitis, sexually transmitted infection, lifetime sexual partner count, and recreational drug use in a population of men who have sex with men. LUTS in men are a source of considerable morbidity, distress, a...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2011.07.1412

    authors： Breyer BN,Vittinghoff E,Van Den Eeden SK,Erickson BA,Shindel AW

    更新日期：2012-01-01 00:00:00

  • Isolated large hydatid cyst in the kidney of an elderly man.

    abstract：:Cystic disease (CD) is a parasitic infestation by Echinococcus granulosus and occurs endemically in many countries, associated with sheep farming. Renal involvement is rare (2-4%) and is often indicative of disseminated disease. Echinococcal larvae can reach the kidneys through the bloodstream or lymph glands or throu...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2011.08.061

    authors： Di Benedetto A,Macchione L,Ciccarello G,Mileto A,Inferrera A,Mucciardi G,Galì A,Ascenti G,Magno C

    更新日期：2012-04-01 00:00:00

  • Effect of intravesical instillation on performance of uCYT+ test.

    abstract：OBJECTIVES:To assess the influence of intravesical instillation of epirubicin or bacille Calmette-Guérin (BCG) in patients with bladder cancer on the clinical performance of the uCyt+ test, which traces the three monoclonal antibodies M344, LDQ 10, and 19A211 in urothelial cells. METHODS:A total of 267 patients with a...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2003.12.023

    authors： Lodde M,Mian C,Negri G,Vittadello F,Comploj E,Palermo S,Staffler A,Brössner C,Pycha A

    更新日期：2004-05-01 00:00:00

  • An Enhancing Mass Abutting the Collecting System.

    abstract：:We present a clinical imaging question focusing on a patient with a history of gross hematuria and an enhancing mass abutting the left renal collecting system. In patients with nondiagnostic cytology and imaging, upper tract urothelial carcinoma should be explored as a potential etiology prior to definitive surgical m...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2020.08.042

    authors： Hill H,Williams J,Larsen G

    更新日期：2020-12-01 00:00:00

  • Wound infiltration with bupivacaine and intramuscular diclofenac reduces postoperative tramadol consumption in patients undergoing radical retropubic prostatectomy: a prospective, double-blind, placebo-controlled, randomized study.

    abstract：OBJECTIVES:To assess the impact of wound infiltration with bupivacaine and i.m. diclofenac administration on patient-controlled analgesia (PCA) tramadol consumptions and postoperative pain in patients who underwent radical retropubic prostatectomy (RRP) under general anesthesia. Previous studies have found only limited...

    journal_title：Urology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.urology.2011.07.1428

    authors： Bilgin TE,Bozlu M,Atici S,Cayan S,Tasdelen B

    更新日期：2011-12-01 00:00:00

  • Plasmakinetic enucleation of the prostate vs plasmakinetic resection of the prostate for benign prostatic hyperplasia: comparison of outcomes according to prostate size in 310 patients.

    abstract：OBJECTIVE:To compare the safety and efficiency of plasmakinetic enucleation of the prostate (PKEP) with that of plasmakinetic resection of the prostate (PKRP) in the treatment of benign prostatic hyperplasia (BPH). MATERIALS AND METHODS:Three hundred ten patients diagnosed to have BPH were randomized to undergo either...

    journal_title：Urology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.urology.2014.06.025

    authors： Luo YH,Shen JH,Guan RY,Li H,Wang J

    更新日期：2014-10-01 00:00:00

  • Incidence of local recurrence and port site metastasis after laparoscopic radical nephroureterectomy.

    abstract：OBJECTIVES:To address the incidence of local recurrence and port site metastasis in patients who underwent laparoscopic radical nephroureterectomy (RNU) for upper tract transitional cell carcinoma (TCC). METHODS:Between August 1993 and February 2006 116 laparoscopic RNU were performed in 115 patients at our institutio...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2007.07.027

    authors： Muntener M,Schaeffer EM,Romero FR,Nielsen ME,Allaf ME,Brito FA,Pavlovich CP,Kavoussi LR,Jarrett TW

    更新日期：2007-11-01 00:00:00

  • Levels of nitric oxide metabolites do not increase during penile erection.

    abstract：:Cavernosal smooth muscle relaxation, one of the primary events in penile erection, is initiated by the synthesis and release of nitric oxide (NO) from the neurons of the cavernosa. The present study was undertaken to determine whether or not serum levels of NO metabolites rise during an erection. Since NO is rapidly c...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(93)90271-b

    authors： Moriel EZ,Gonzalez-Cadavid N,Ignarro LJ,Byrns R,Rajfer J

    更新日期：1993-11-01 00:00:00

  • Quantification of preoperative stone burden for ureteroscopy and shock wave lithotripsy: current state and future recommendations.

    abstract：OBJECTIVES:To determine which preprocedure imaging modality was used and how the stone burden quantification was assessed before shock wave lithotripsy (SWL) and ureteroscopy (URS) in published studies. MATERIAL AND METHODS:References were searched in the MEDLINE database using the terms "shock wave lithotripsy" and "...

    journal_title：Urology

    pub_type： 杂志文章,评审

    doi：10.1016/j.urology.2010.12.009

    authors： Patel SR,Nakada SY

    更新日期：2011-08-01 00:00:00

  • Koyanagi- Snow-Hayashi urethroplasty in severe hypospadias repair: Between hope and reality.

    abstract：OBJECTIVE:To present the results of Koyanagi-Snow-Hayashi urethroplasty in severe hypospadias repair. METHODS:From June 2015 to December 2019, 43 patients with severe hypospadias associated with curvature underwent Koyanagi- Snow-Hayashi urethroplasty. All patients were treated for the first time and by a single surge...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2020.11.058

    authors： Acimi S,Abderrahmane N,Debbous L,Acimi MA,Mansouri J

    更新日期：2021-01-08 00:00:00

  • Role of urothelial surface mucoprotein in intrinsic bladder defense.

    abstract：:To implicate further the surface mucoprotein as the factor responsible for preventing bacterial attachment to the bladder mucosa, rabbit urothelium was severely disrupted and allowed to regenerate for varying periods of time. Quantitative measurements of the attachment of 14C-labeled Escherichia coli were correlated w...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(77)90245-x

    authors： Shrom SH,Parsons CL,Mulholland SG

    更新日期：1977-05-01 00:00:00

  • Efficacy of candicidin in benign prostatic hypertrophy.

    abstract：:Forty-three patients with benign prostatic hypertrophy with marked urinary distress, which I believed warranted surgical treatment, were selected from private practice. These patients were treated with long-term conservative therapy to determine the efficacy of candicidin for this condition. Patients receiving candici...

    journal_title：Urology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0090-4295(74)90113-7

    authors： Orkin LA

    更新日期：1974-07-01 00:00:00

  • Relationship between renal parenchymal volume and single kidney glomerular filtration rate before and after unilateral nephrectomy.

    abstract：OBJECTIVES:To measure the renal parenchymal volume (RPV) before and after unilateral nephrectomy and investigate the relationship between the RPV and single kidney glomerular filtration rate (GFR). METHODS:From November 2003 to August 2009, 183 patients who had undergone unilateral nephrectomy were enrolled in the pre...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2010.03.063

    authors： Funahashi Y,Hattori R,Yamamoto T,Kamihira O,Sassa N,Gotoh M

    更新日期：2011-06-01 00:00:00

  • Congenital posterior urethral valves in an adult.

    abstract：:An adult male with posterior urethral valves who had obstructive urinary symptoms and painless gross hematuria is presented. The diagnosis, development, and treatment of posterior urethral valves is discussed. The importance of also treating the hypertrophied bladder neck is stressed. ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：

    authors： Saraf PG,Valvo JR,Frank IN

    更新日期：1984-01-01 00:00:00

  • Human papillomavirus detection by polymerase chain reaction in benign and malignant prostate tissue is dependent on the primer set utilized.

    abstract：OBJECTIVES:Prior investigations evaluating the presence of human papillomavirus (HPV) in prostatic tissue by polymerase chain reaction (PCR) technology have yielded detection rates of 0% to 100%. Contamination by viral DNA from prostatic urethral colonization or less than optimal laboratory conditions have been suggest...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/S0090-4295(97)00126-X

    authors： Terris MK,Peehl DM

    更新日期：1997-07-01 00:00:00

  • Chemosensitivity of malignant ovarian-type surface epithelial tumor of testis.

    abstract：:Malignant ovarian-type surface epithelial tumors of the testis and paratestis are rare neoplasms. The chemosensitivity of these tumors has not been previously documented. We report a patient with metastatic disease with demonstrated responsiveness to chemotherapy treatments used in advanced ovarian cancer. ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2005.03.032

    authors： Vaughn DJ,Rizzo TA,Malkowicz SB

    更新日期：2005-09-01 00:00:00

  • Urinary symptoms associated with human T-cell lymphotropic virus type I infection: evidence of urinary manifestations in large group of HTLV-I carriers.

    abstract：OBJECTIVES:To describe the frequency of urologic manifestations in human T-cell lymphotropic virus type I (HTLV-I) seropositive individuals from Salvador and other cities in Bahia, Brazil, with or without clinical HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). METHODS:A total of 218 HTLV-I seropo...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2007.01.052

    authors： Castro NM,Rodrigues W Jr,Freitas DM,Muniz A,Oliveira P,Carvalho EM

    更新日期：2007-05-01 00:00:00

  • Extracorporeal shock-wave lithotripsy in horseshoe kidneys.

    abstract：:Using the Dornier HM-3 lithotriptor, 10 patients (11 renal units) with calculi in horseshoe kidneys were treated with extracorporeal shock-wave lithotripsy (ESWL) and ancillary procedures. Six renal units (55%) underwent pre-ESWL manipulation consisting of a Double J stent, ureteral catheter, or percutaneous nephrosto...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(90)80082-x

    authors： Locke DR,Newman RC,Steinbock GS,Finlayson B

    更新日期：1990-05-01 00:00:00