Role of urothelial surface mucoprotein in intrinsic bladder defense.

Abstract:

:To implicate further the surface mucoprotein as the factor responsible for preventing bacterial attachment to the bladder mucosa, rabbit urothelium was severely disrupted and allowed to regenerate for varying periods of time. Quantitative measurements of the attachment of 14C-labeled Escherichia coli were correlated with the histologic presence of the surface mucoprotein. Control levels of bacterial attachment were observed only when the PAS-positive layer had regenerated, further supporting the role of this layer in the bladder's antibacterial defense.

journal_name

Urology

journal_title

Urology

authors

Shrom SH,Parsons CL,Mulholland SG

doi

10.1016/0090-4295(77)90245-x

subject

Has Abstract

pub_date

1977-05-01 00:00:00

pages

526-33

issue

5

eissn

0090-4295

issn

1527-9995

journal_volume

9

pub_type

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