Abstract：
BACKGROUND AND PURPOSE:Nitric oxide is critical in the regulation of cerebral blood flow and smooth muscle proliferation. It is synthesized by 3 nitric oxide synthase (NOS) isoforms: neuronal, inducible, and endothelial NOS (eNOS). Aneurysmal subarachnoid hemorrhage (aSAH) causes endothelial dysfunction that, in turn, contributes to pathophysiologic processes surrounding aSAH. Previous studies reported an association of an eNOS single nucleotide polymorphism (SNP) with the clinical sequelae of aSAH. Here, we further elucidate the impact of this eNOS SNP on the clinical course after aSAH. METHODS:The Cerebral Aneurysm Renin Angiotensin System study prospectively enrolled aSAH patients at 2 academic institutions in the United States from 2012-2015. Blood samples from all patients enrolled in the study were used for genetic evaluation using 5'exonuclease (Taqman) genotyping assays. Associations between the eNOS SNP rs2070744 (786 T->C) and clinical course after aSAH were analyzed. RESULTS:Samples from 149 aSAH patients were available for analysis. The C allele of the eNOS SNP independently predicted an increased risk for delayed cerebral ischemia (OR = 2.936, 95% CI 1.048-8.226, P = 0.040). The eNOS SNP rs2070744 was not associated with functional outcome or size of aneurysm at the time of rupture. CONCLUSIONS:The present study is the first to demonstrate that the C allele of the eNOS SNP 786 T->C rs2070744 is independently associated with an increased risk for delayed cerebral ischemia following aSAH.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Hendrix P,Foreman PM,Harrigan MR,Fisher WS 3rd,Vyas NA,Lipsky RH,Lin M,Walters BC,Tubbs RS,Shoja MM,Pittet JF,Mathru M,Griessenauer CJdoi
10.1016/j.wneu.2017.02.062subject
Has Abstractpub_date
2017-05-01 00:00:00pages
514-519eissn
1878-8750issn
1878-8769pii
S1878-8750(17)30235-8journal_volume
101pub_type
杂志文章abstract：BACKGROUND:Intraneural ganglia are benign mucinous cystic formations that originate within the epineurium of peripheral nerves. Different treatments have been recommended, with an overall satisfactory outcome. In this paper, we aim to evaluate the long-term outcomes of surgical treatment of peroneal intraneural ganglia...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.08.195
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:The anterior-only surgical procedure, including discectomy, open reduction, fusion, and fixation, is a recommended approach in the treatment of cervical facet dislocations. This approach has a reduction failure rate of up to 40%. When it fails, a posterior approach is usually required. OBJECTIVE:To report a...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.04.153
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Carotid free-floating thrombus (CFFT) is defined as a blood clot attached to the arterial wall with surrounding blood flow at its distal component. Although rare, it is a clinically significant cause of embolic stroke. CFFT within a stent has not been previously reported. CASE DESCRIPTION:We report a 64-yea...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2020.06.100
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:Patients with diffuse low-grade gliomas (DLGGs) typically present with seizures. We sought to review the neurosurgical literature for seizure outcome after resection of these tumors. METHODS:Using PubMed, we identified surgical series reporting seizure freedom rates for grade II astrocytoma, oligoastrocytoma...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.06.144
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:The supraorbital keyhole approach (SKA) and pterional approach (PA) have been recommended for clipping intracranial aneurysms (IAs). We conducted a meta-analysis to systematically and comprehensively compare the clinical outcomes between the 2 approaches. METHODS:We retrieved potential academic studies that...
journal_title：World neurosurgery
pub_type： 杂志文章,meta分析
doi：10.1016/j.wneu.2019.11.134
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:The Internet has become a popular resource for patients to research diagnosed or suspected medical diseases. Medical institutions provide comprehensive online education resources about various conditions to the general public. The U.S. National Institutes of Health and American Medical Association recommend ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.11.109
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVE:Measurement of the optic nerve sheath diameter (ONSD) by using sonography is a straightforward, noninvasive technique to detect an increased intracranial pressure, which can even be conducted at the bedside. However, the correlation between ONSD and intracranial midline shift has not been studied. METHODS:Th...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.10.015
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:In acute ischemic stroke with large vessel occlusion, the interaction between the clot retriever and the stent is critical for achieving successful recanalization. The ideal time of stent deployment (dwell time [DT]) to improve revascularization is currently unknown. We systematically analyzed the effect of d...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.10.155
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Decompressive craniectomy procedures are performed in patients with malignant intracranial hypertension. A bone flap is removed to relieve pressure. Later, a second operation is performed to reconstruct the skull after brain swelling has resolved. This surgical treatment would be improved if it were possible...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.08.095
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Colloid cysts of the third ventricle are benign congenital lesions. They are at times totally asymptomatic or may be detected in the evaluation for headache, neurologic disturbances, or psychiatric disturbances. They may sometimes cause grave consequences such as coma or even sudden death. The radiologic app...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2020.05.164
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Fibrous dysplasia (FD) is most often a slowly progressive benign disease in which the normal bone structure is replaced by fibrous and osteoid tissue. CASE DESCRIPTION:A 16-year-old adolescent, known with FD in the sphenoid bone, suffered an acute decreased visual acuity with papilledema on the left eye. Th...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.08.175
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:To identify causes of recurrent hemifacial spasm (HFS) after initial microvascular decompression (MVD) and to assess the feasibility of redo MVD. METHODS:The study included 21 patients who underwent redo MVD over the last 2 decades. Their medical charts were retrospectively reviewed for preoperative medical ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.05.231
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:Previous reports suggest that patients with Parkinson disease (PD) have elevated rates of complications following spine surgery; however, these reports are limited by small patient series. In this study, we used the National Inpatient Sample (NIS) database to compare in-hospital complications following elect...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.07.006
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:An isolated, unilateral fracture of the C1 lateral mass is a rare condition that has been only minimally described in the literature. Historically, these fractures have predominantly been managed conservatively with either external immobilization or traction. CASE DESCRIPTION:We review the literature and pr...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.09.206
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Traumatic brain injury (TBI) remains a life-threatening condition characterized by growing incidence worldwide, particularly in the aging population, in which the primary goal of treatment appears to be avoidance of chronic institutionalization. METHODS:To identify independent predictors of 30-day mortality...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.04.060
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Although carotid artery stenting (CAS) has been widely acknowledged as an effective alternative option for patients at high risk of carotid endarterectomy, embolic stroke is a major complication of CAS. Several reports have emphasized that distal protection filter alone is associated with a high risk of embo...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.05.028
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Plaque characteristics play pivotal roles in ischemic events, but stenosis severity does not accurately reflect carotid plaque volume due to expansive remodeling in some patients with low-grade stenosis (LGS). This study aimed to assess the safety, efficacy, and durability of carotid endarterectomy (CEA) for...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.11.208
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Previous studies compared outcomes of intracranial meningioma surgery in octogenarians with outcomes in younger patients without accounting for different tumor locations and sizes. The aim of the current study was to evaluate outcomes of intracranial meningioma surgery in octogenarians taking into account pa...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.09.001
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:The pathophysiology of spinal cord injury (SCI) with the information obtained to date has not been elucidated fully. A safe drug or treatment protocol that results in cell regeneration for SCI remains unknown. Neuroprotective and neuroregenerative effects of riluzole, administered after a SCI, have been shown...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.02.171
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Although targeted by radiotherapy, recurrence in glioblastoma occurs mainly periresectionally owing to tumor infiltration. An increase in the apparent diffusion coefficient (ADC) has been shown in the large high-T2 area on magnetic resonance imaging posttreatment; however, until now ADC has not been investig...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.04.129
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Anterior sacral meningocele (ASM) is characterized by a herniation of the dural sac through a bony defect of the anterior sacral wall. Symptoms of ASMs are usually directly related to their mass effect on the adjacent pelvic structures, often causing chronic constipation and urinary disturbances. The low-dys...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.04.105
更新日期：2019-09-01 00:00:00
abstract：:The innominate artery, also known as the brachiocephalic artery, is the first vessel off the aortic arch and provides blood to the right arm, neck, and head. Occlusion of the innominate artery can be treated with endarterectomy, angioplasty, stenting, and bypass grafting. Bypass grafting describes a surgical procedure...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.05.134
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:No widely accepted gold standard for diagnosis of shunt infection exists, with definitions variable among clinicians and publications. This article summarizes the utility of commonly used diagnostic tools and provides a comprehensive review of optimal measures for diagnosis. METHODS:A query of PubMed was pe...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.05.057
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:Although the endoscopic transpterygoid approach has been popularized, there are no studies about anatomy-specific morbidities of this approach. The objective of this study is to investigate the surgical morbidities associated with the endoscopic transpterygoid approach for resection of anatomic structures. M...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.12.023
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:To investigate initial pain relief and subsequent recurrence after percutaneous balloon compression (PBC) and describe its association with the nature of trigeminal pain, previous procedures, or other clinical factors. METHODS:A total of 222 patients with medically refractory trigeminal pain treated with PBC...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.03.111
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:To observe the clinical effects of posterior percutaneous full-endoscopic cervical foraminotomy in patients with osseous foraminal stenosis. METHODS:Nine patients with osseous foraminal stenosis underwent surgery using the posterior percutaneous full-endoscopic cervical foraminotomy technique and received fo...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.07.085
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Trigeminal neuralgia (TGN) is a debilitating disorder, and in patients for whom medical management is not sufficient, there are several therapeutic options. Microvascular decompression (MVD) for TGN has been shown to be highly effective; however, pain does recur after MVD in some patients. Therapeutic option...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.05.147
更新日期：2018-09-01 00:00:00
abstract：OBJECTIVE:Large or giant thrombosed intracranial aneurysms (LGTIAs) are highly associated with poor prognosis and remain a challenging disease to treat by either surgery or endovascular treatment (EVT). EVT is considered more difficult for complicated aneurysm like LGTIAs. To understand long-term clinical and angiograp...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.08.213
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Ganglion cysts mostly occur in the knuckles and wrists, but they rarely present in the odontoid process and can cause neurological symptoms by compressing the spinal cord. They are mostly localized in the epidural space, but may very rarely appear in the intradural space. There are no reports of cases of int...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2020.08.120
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:In 2000, we advised against insertion of a ventriculoperitoneal shunt (VPS) in human immunodeficiency virus (HIV)-positive patients with tuberculous meningitis (TBM) complicated by hydrocephalus. However, this was in the era when combination antiretroviral therapy (ART) was not freely available in South Afri...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.11.221
更新日期：2019-03-01 00:00:00
