当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY期刊下所有文献 > A high neutrophil-to-lymphocyte ratio as a potential marker of mortality in patients with Merkel cell carcinoma: A retrospective study.

A high neutrophil-to-lymphocyte ratio as a potential marker of mortality in patients with Merkel cell carcinoma: A retrospective study.

Abstract：

BACKGROUND:The prognostic relevance of a high blood neutrophil-to-lymphocyte ratio (NLR) has been reported in many cancers, although, to our knowledge, not investigated in patients with Merkel cell carcinoma (MCC) to date. OBJECTIVE:We assessed whether the NLR at baseline was associated with specific survival and recurrence-free survival in MCC. METHODS:We retrospectively included MCC cases between 1999 and 2015 and collected clinical data, blood cell count at baseline, and outcome. A Cox model was used to identify factors associated with recurrence and death from MCC. RESULTS:Among the 75 patients included in the study, a high NLR at baseline (NLR ≥4) was associated with death from MCC in univariate (hazard ratio 2.76, 95% confidence interval 1.15-6.62, P = .023) and multivariate (hazard ratio 3.30, 95% confidence interval 1.21-9.01, P = .020) analysis, but not with recurrence. LIMITATIONS:Because of the retrospective design, we excluded patients with missing data and not all confounding factors that may influence the NLR were available. CONCLUSION:A high NLR at baseline was independently associated with specific mortality in patients with MCC. The NLR seems to constitute an easily available and inexpensive prognostic biomarker at baseline.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Zaragoza J,Kervarrec T,Touzé A,Avenel-Audran M,Beneton N,Esteve E,Wierzbicka Hainaut E,Aubin F,Machet L,Samimi M

doi

10.1016/j.jaad.2016.05.045

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

712-721.e1

issue

4

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(16)30329-2

journal_volume

75

pub_type

杂志文章

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