当前位置： SCI文献检索 > BIOCHEMICAL PHARMACOLOGY期刊下所有文献 > Investigation of the role of serum lipoprotein-associated peroxides in Adriamycin cardiotoxicity. Release of reduced glutathione from rat hearts perfused with lipase-hydrolyzed very low density lipoprotein fractions obtained from Adriamycin-treated and co

Investigation of the role of serum lipoprotein-associated peroxides in Adriamycin cardiotoxicity. Release of reduced glutathione from rat hearts perfused with lipase-hydrolyzed very low density lipoprotein fractions obtained from Adriamycin-treated and co

Abstract：

:In a previous study, we demonstrated that the serum of rats treated chronically with the anticancer agent Adriamycin contains lipid peroxides associated with neutral lipids (W. S. Thayer, Biochem Pharmacol 33: 2259-2263, 1984). In the present study, hearts from untreated control rats were perfused with medium containing serum or very low density lipoprotein (VLDL) fractions obtained from either Adriamycin-treated rats or control rats. Release of endogenous glutathione from the perfused heart was tested to evaluate possible metabolism of the serum lipid peroxides through the glutathione peroxidase/glutathione reductase redox cycle. Perfusion with lipoprotein lipase-hydrolyzed serum or VLDL caused glutathione release, the extent of which increased with increasing VLDL concentration in the perfusate. The effect was not unique for VLDL from Adriamycin-treated rats, but instead appeared to be a more general phenomenon since it was also observed with VLDL from control rats. Glutathione was released in the reduced form (GSH), rather than the oxidized form (GSSG) observed during perfusions with model peroxides. Pretreatment of the VLDL with lipoprotein lipase in vitro prior to perfusion was necessary in order to obtain GSH release. Neither lipase alone nor palmitate in the absence of lipase was as effective in promoting GSH release. Simultaneous release of lactate dehydrogenase was quantitatively less than that of GSH. The results suggest an action of components of serum VLDL on cardiac membrane permeability. Peroxide metabolism-linked perturbation of the cardiac glutathione redox cycle does not appear to be the mode of action for the serum lipid peroxides found in Adriamycin-treated rats.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Thayer WS

doi

10.1016/0006-2952(89)90490-5

subject

Has Abstract

pub_date

1989-06-15 00:00:00

pages

1923-9

issue

12

eissn

0006-2952

issn

1873-2968

pii

0006-2952(89)90490-5

journal_volume

38

pub_type

杂志文章

相关文献

BIOCHEMICAL PHARMACOLOGY文献大全
  • Modulation of GSH levels in ABCC1 expressing tumor cells triggers apoptosis through oxidative stress.

    abstract：:The over-expression of ABCC1 transmembrane protein has been shown to cause multidrug resistance in tumor cell lines. ABCC1 is a member of the ABC transmembrane proteins that function as efflux pumps with diverse substrate specificity. Several endogenous cell metabolites, including the leukotriene C4 (LTC(4)) and gluta...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.bcp.2007.02.005

    authors： Laberge RM,Karwatsky J,Lincoln MC,Leimanis ML,Georges E

    更新日期：2007-06-01 00:00:00

  • Binding of colchiceine to tubulin. Mechanisms of ligand association with tubulin.

    abstract：:Colchiceine, a closely related structural analog of colchicine possessing a C-ring tropolone, has been shown to be a potent inhibitor of microtubule assembly in vitro (I50 = 20 microM). The mechanism of inhibition is mediated through binding to tubulin (KA = 1.2 +/- 0.7 x 10(4) M-1), although potentially not through t...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/0006-2952(90)90002-3

    authors： Hastie SB,Macdonald TL

    更新日期：1990-04-15 00:00:00

  • Structure-activity relationships of alkylamines that inhibit rat liver hydroxysteroid sulfotransferase activities in vitro.

    abstract：:Tetraalkylammonium salts having n-propyl to n-amyl side chains inhibited rat liver sulfotransferase (ST) activities toward dehydroepiandrosterone and cortisol, but not ST activity toward 2-naphthol, whereas trialkylamines having ethyl to n-amyl side chains inhibited ST activity toward dehydroepiandrosterone, but not S...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/0006-2952(94)00495-8

    authors： Matsui M,Takahashi M,Miwa Y,Motoyoshi Y,Homma H

    更新日期：1995-03-01 00:00:00

  • Vasoactive intestinal polypeptide does not affect thyroid follicular cell membrane potential or input resistance.

    abstract：:It has been suggested that vasoactive intestinal polypeptide (VIP) has a role as a neurotransmitter and that it participates in the control of hormone release from thyroid follicles. Many hormones and neurotransmitters alter the ionic permeability properties of the plasma membrane of their target cells when they bind ...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/0006-2952(87)90671-x

    authors： Green ST

    更新日期：1987-12-15 00:00:00

  • Evidence for separate effects of U73122 on phospholipase C and calcium channels in human platelets.

    abstract：:U73122 ((1-[6-(( 17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)exyl]-1H-p yrrole-2,5-dione)) is generally used as a selective inhibitor of phospholipase C (PLC) and the related rise in cytosolic Ca2+. Recently, by using hepatocytes, it was suggested that its action sites are different for PLC activation and increa...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0006-2952(98)00146-4

    authors： Pulcinelli FM,Gresele P,Bonuglia M,Gazzaniga PP

    更新日期：1998-12-01 00:00:00

  • The GABAA receptor-gated ion channel: biochemical and pharmacological studies of structure and function.

    abstract：:In the past few years, substantial advances have been made in analyzing the structure and function of the GABA receptor-gated Cl- channel. A major goal is to identify the molecular characteristics of the GABAA receptor that are necessary for maintaining normal GABAergic neurotransmission. Future studies will undoubted...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/0006-2952(88)90684-3

    authors： Schwartz RD

    更新日期：1988-09-15 00:00:00

  • On Becoming a Pharmacologist: Channeling David Triggle.

    abstract：:This Festschrift contribution summarizes the perspectives of two of David Triggle's graduate students. Both share somewhat parallel scientific and career paths-i.e., enrolling in the Biochemical Pharmacology program at the University of Buffalo, pursuing graduate training under the mentorship of David Triggle and subs...

    journal_title：Biochemical pharmacology

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.bcp.2015.08.002

    authors： Rampe D,Gopalakrishnan M

    更新日期：2015-11-15 00:00:00

  • SMAD-oncoprotein interplay: Potential determining factors in targeted therapies.

    abstract：:The Transforming Growth Factor-β (TGF-β) signaling pathway plays a versatile role in diverse physiological and disease conditions. Outcomes of TGF-β signaling are divergent, sometimes even opposite, on cellular functions and disease progression through context-dependent transcriptional programs. For example, TGF-β sig...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.bcp.2020.114155

    authors： Li X,Feng XH

    更新日期：2020-10-01 00:00:00

  • Ca2+/calmodulin-dependent protein kinase II regulation by inhibitor 1 of protein phosphatase 1 alleviates necroptosis in high glucose-induced cardiomyocytes injury.

    abstract：:Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays an important role in the cardiovascular system. However, the potential protective role of inhibitor 1 of protein phosphatase 1 (I1PP1), which is able to regulate CaMKII, in high glucose-induced cardiomyocytes injury remains unknown. In the present study, cardi...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.bcp.2019.02.022

    authors： Sun L,Chen Y,Luo H,Xu M,Meng G,Zhang W

    更新日期：2019-05-01 00:00:00

  • P2X7 receptor and the NLRP3 inflammasome: Partners in crime.

    abstract：:Adenosine triphosphate (ATP) is a molecule that on one hand plays a central role in cellular energetics and which on the other is a ubiquitous signaling molecule when released into the extracellular media. Extracellular ATP accumulates in inflammatory environments where it acts as a damage-associated molecular pattern...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.bcp.2020.114385

    authors： Pelegrin P

    更新日期：2020-12-20 00:00:00

  • Cinnamic aldehyde suppresses hypoxia-induced angiogenesis via inhibition of hypoxia-inducible factor-1α expression during tumor progression.

    abstract：:During tumor progression, hypoxia-inducible factor 1 (HIF-1) plays a critical role in tumor angiogenesis and tumor growth by regulating the transcription of several genes in response to a hypoxic environment and changes in growth factors. This study was designed to investigate the effects of cinnamic aldehyde (CA) on ...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.bcp.2015.08.095

    authors： Bae WY,Choi JS,Kim JE,Jeong JW

    更新日期：2015-11-01 00:00:00

  • Differential effects of in vitro peroxidation on peripheral- and central-type benzodiazepine receptors. Protection by diverse antioxidants.

    abstract：:The influence of various concentrations of ferrous iron and ascorbate on in vitro peroxidation and drug binding of diverse membrane preparations (cerebral cortex and liver) was studied. Peroxidation was not simply dose-related to ascorbate and ferrous iron, but a complex relationship between iron and ascorbate when ad...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/0006-2952(95)02058-6

    authors： Courtiere A,Molard F,Reybaud J

    更新日期：1995-11-27 00:00:00

  • Characterization of the benzene monooxygenase system in rabbit bone marrow.

    abstract：:The microsomal fraction of bone marrow contains cytochrome P-450 (39 +/- 11 pmoles/mg microsomal protein) and monooxygenase activity could be demonstrated by the O-dealkylation of 7-ethoxycoumarin (114 +/- 65 pmoles/(min X mg microsomal protein] and the hydroxylation of benzene to phenol (51 +/- 8.6 pmol/45 min X mg m...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/0006-2952(84)90143-6

    authors： Gollmer L,Graf H,Ullrich V

    更新日期：1984-11-15 00:00:00

  • Species-dependent differences in the biochemical effects and metabolism of 5-benzylacyclouridine.

    abstract：:The pharmacokinetics and biochemical effects of the uridine phosphorylase (UrdPase) inhibitor 5-benzylacyclouridine (BAU) were investigated in the mouse, rat and monkey. Following i.p. administration of BAU (30 mg/kg) in the mouse and i.v. administration in the rat and monkey, initial BAU plasma half-life values were ...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/0006-2952(93)90390-i

    authors： Davis ST,Joyner SS,Chandrasurin P,Baccanari DP

    更新日期：1993-01-07 00:00:00

  • Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes.

    abstract：:Metabolic and cardiovascular disease patients have increased plasma levels of lipids and, specifically, of palmitate, which can be toxic for several tissues. Trimetazidine (TMZ), a partial inhibitor of lipid oxidation, has been proposed as a metabolic modulator for several cardiovascular pathologies. However, its mech...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.bcp.2014.07.022

    authors： Kuzmicic J,Parra V,Verdejo HE,López-Crisosto C,Chiong M,García L,Jensen MD,Bernlohr DA,Castro PF,Lavandero S

    更新日期：2014-10-01 00:00:00

  • In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises.

    abstract：:Enzymes of the UDP-glucuronosyltransferase (UGT) superfamily are responsible for the metabolism of many drugs, environmental chemicals and endogenous compounds. Identification of the UGT(s) involved in the metabolism of a given compound ('reaction phenotyping') currently relies on multiple confirmatory approaches, whi...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.bcp.2005.12.019

    authors： Miners JO,Knights KM,Houston JB,Mackenzie PI

    更新日期：2006-05-28 00:00:00

  • Cyclosporin A and tacrolimus induce renal Erk1/2 pathway via ROS-induced and metalloproteinase-dependent EGF-receptor signaling.

    abstract：:We previously demonstrated that the widely used immunosuppressive drugs cyclosporin A (CsA) and tacrolimus (FK506), independent of immunophilin binding, can activate profibrogenic transforming growth factor β (TGFβ)/Smad signaling cascades in rat renal mesangial cells (MC). Here we report that both peptidyl-prolyl cis...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.bcp.2011.11.001

    authors： Akool el-S,Gauer S,Osman B,Doller A,Schulz S,Geiger H,Pfeilschifter J,Eberhardt W

    更新日期：2012-01-15 00:00:00

  • Effect of mevinolin on cholesterol metabolism in obese and lean Zucker rats.

    abstract：:Mevinolin is a potent competitive inhibitor of HMG-CoA reductase, the enzyme catalyzing the major rate-limiting step in cholesterol synthesis. In this study the drug was administered as an intragastric dose at 2.5 mg/kg/day to 10 to 12-week-old lean and obese Zucker female rats over a 5-day period. Mevinolin showed no...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/0006-2952(87)90179-1

    authors： McCune SA,Jurin RR

    更新日期：1987-03-15 00:00:00

  • Evidence for acyloxymethyl esters of pyrimidine 5'-deoxyribonucleotides as extracellular sources of active 5'-deoxyribonucleotides in cultured cells.

    abstract：:Cells commonly resist growth inhibition by purine and pyrimidine bases and nucleosides by restricting intracellular formation of the corresponding 5'-mononucleotides. Nucleotide derivatives that can act as effective membrane-transport precursors of the poorly membrane-permeable nucleotides have not been identified so ...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/0006-2952(89)90613-8

    authors： Freed JJ,Farquhar D,Hampton A

    更新日期：1989-10-01 00:00:00

  • Acetaminophen hepatotoxicity. An alternative mechanism.

    abstract：:Alcohol-fed hamsters were used to study the mechanism by which acetaminophen initiates hepatotoxicity. Animals maintained on an ethanol-containing diet (Group B) exhibited an increased mortality rate after administration of acetaminophen (400 mg/kg) as compared to control hamsters (Group A). However, in those animals ...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/0006-2952(83)90426-4

    authors： Rosen GM,Singletary WV Jr,Rauckman EJ,Killenberg PG

    更新日期：1983-07-01 00:00:00

  • Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen.

    abstract：:The prevalence of hyperuricemia/gout increases with aging. However, the effect of aging on function for excretion of uric acid to out of the body has not been clarified. We found that ileal uric acid clearance in middle-aged rats (11-12 months) was decreased compared with that in young rats (2 months). In middle-aged ...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.bcp.2015.06.021

    authors： Ogura J,Kuwayama K,Sasaki S,Kaneko C,Koizumi T,Yabe K,Tsujimoto T,Takeno R,Takaya A,Kobayashi M,Yamaguchi H,Iseki K

    更新日期：2015-09-01 00:00:00

  • Effects of full and partial beta-adrenergic agonists and antagonists on human lung adenylate cyclase.

    abstract：:The beta-adrenergic stimulation of adenylate cyclase in membranes from human lung was compared to that of adenylate cyclase in membranes with a majority of beta 2-adrenergic receptors (from rat lung) and in membranes with a homogeneous population of beta 2-adrenergic receptors (from rat erythrocytes and reticulocytes)...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/0006-2952(83)90046-1

    authors： Delhaye M,Taton G,Camus JC,Chatelain P,Robberecht P,Waelbroeck M,Christophe J

    更新日期：1983-06-15 00:00:00

  • Inhibition of renal ornithine decarboxylase by aminoglycoside antibiotics in vitro.

    abstract：:The inhibition of renal ornithine decarboxylase (ODC) by aminoglycoside antibiotics was characterized in the postmitochondrial fraction of a kidney homogenate from adult pigmented guinea pigs. Enzymatic activity was defined as the rate of decarboxylation of [14C]ornithine sensitive to a specific ODC inhibitor, alpha-d...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/0006-2952(88)90427-3

    authors： Henley CM 3rd,Mahran LG,Schacht J

    更新日期：1988-05-01 00:00:00

  • Modulation of cell sensitivity to antitumor agents by targeting survival pathways.

    abstract：:The advent of drugs targeting tumor-associated prosurvival alterations of cancer cells has changed the interest of antitumor drug development from cytotoxic drugs to target-specific agents. Although single-agent therapy with molecularly targeted agents has shown limited success in tumor growth control, a promising str...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.bcp.2010.07.030

    authors： Perego P,Cossa G,Zuco V,Zunino F

    更新日期：2010-11-15 00:00:00

  • Inhibition of ribonucleotide reductase and L1210 cell growth by N-hydroxy-N'-aminoguanidine derivatives.

    abstract：:A series of N-hydroxy-N'-aminoguanidine derivatives was studied for their effects on L1210 cell growth and ribonucleotide reductase activity. With the twelve compounds studied, there was a good correlation between the inhibition of L1210 cell growth and the inhibition of ribonucleotide reductase activity. The most pot...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/0006-2952(85)90561-1

    authors： Cory JG,Carter GL,Bacon PE,T'ang A,Lien EJ

    更新日期：1985-08-01 00:00:00

  • Inhibition of mast cell mediator release by 5-amino-4-imidazolecarboxamide riboside.

    abstract：:Stimulated mast cells produce and release adenosine, and the release of mast cell mediators is potentiated by adenosine, yet very little is known regarding mast cell purine metabolism. Because 5-amino-4-imidazolecarboxamide riboside (AICA riboside) has been shown to alter adenosine metabolism and accelerate the replet...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/0006-2952(86)90757-4

    authors： Marquardt DL,Gruber HE

    更新日期：1986-12-15 00:00:00

  • Evidence for the metabolism of mitozantrone by microsomal glutathione transferases and 3-methylcholanthrene-inducible glucuronosyl transferases.

    abstract：:The metabolism of mitozantrone, a chemotherapeutic agent used in the treatment of breast cancer, has been studied in vitro using rat liver subcellular fractions. This compound would appear to be metabolized by two interesting pathways. One involves conjugation with glucuronic acid, catalyzed most effectively by a 3-me...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/0006-2952(86)90127-9

    authors： Wolf CR,Macpherson JS,Smyth JF

    更新日期：1986-05-01 00:00:00

  • UVB light suppresses nitric oxide production by murine keratinocytes and macrophages.

    abstract：:Nitric oxide is an important mediator of excessive cell growth and inflammation associated with many epidermal proliferative disorders. It is a highly reactive oxidant generated in keratinocytes and macrophages via the inducible form of the enzyme nitric oxide synthase (NOS2). In the present studies, we examined the e...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0006-2952(02)01419-3

    authors： Sur R,Heck DE,Mariano TM,Jin Y,Murphy WJ,Laskin JD

    更新日期：2002-11-15 00:00:00

  • Current perspectives on parathyroid hormone (PTH) and PTH-related protein (PTHrP) as bone anabolic therapies.

    abstract：:Osteoporosis is characterized by low bone mineral density and/or poor bone microarchitecture leading to an increased risk of fractures. The skeletal alterations in osteoporosis are a consequence of a relative deficit of bone formation compared to bone resorption. Osteoporosis therapies have mostly relied on antiresorp...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.bcp.2013.03.002

    authors： Esbrit P,Alcaraz MJ

    更新日期：2013-05-15 00:00:00

  • GABAA receptor modulation by piperine and a non-TRPV1 activating derivative.

    abstract：:The action of piperine (the pungent component of pepper) and its derivative SCT-66 ((2E,4E)-5-(1,3-benzodioxol-5-yl))-N,N-diisobutyl-2,4-pentadienamide) on different gamma-aminobutyric acid (GABA) type A (GABA(A)) receptors, transient-receptor-potential-vanilloid-1 (TRPV1) receptors and behavioural effects were invest...

    journal_title：Biochemical pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.bcp.2013.04.017

    authors： Khom S,Strommer B,Schöffmann A,Hintersteiner J,Baburin I,Erker T,Schwarz T,Schwarzer C,Zaugg J,Hamburger M,Hering S

    更新日期：2013-06-15 00:00:00