Are intra-articular injections of hyaluronic acid effective for the treatment of temporomandibular disorders? A systematic review.

Abstract:

:This systematic review aimed to investigate whether intra-articular injections of hyaluronic acid (HA) are better than other drugs used in temporomandibular joint arthrocentesis, for the improvement of temporomandibular disorder (TMD) symptoms. Two independent reviewers performed an electronic search of the MEDLINE and Web of Science databases for relevant studies published in English up to March 2016. The key words used included a combination of 'hyaluronic acid', 'viscosupplementation', 'intra-articular injections', 'corticosteroids', or 'non steroidal anti inflammatory agents' with 'temporomandibular disorder'. Selected studies were randomized clinical trials and prospective or retrospective studies that primarily investigated the application of HA injections compared to other intra-articular medications for the treatment of TMD. The initial screening yielded 523 articles. After evaluation of the titles and abstracts, eight were selected. Full texts of these articles were accessed and all fulfilled the inclusion criteria. Intra-articular injections of HA are beneficial in improving the pain and/or functional symptoms of TMDs. However, other drug therapies, such as corticosteroid and non-steroidal anti-inflammatory drug injections, can be used with satisfactory results. Well-designed clinical studies are necessary to identify an adequate protocol, the number of sessions needed, and the appropriate molecular weight of HA for use.

authors

Goiato MC,da Silva EV,de Medeiros RA,Túrcio KH,Dos Santos DM

doi

10.1016/j.ijom.2016.06.004

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

1531-1537

issue

12

eissn

0901-5027

issn

1399-0020

pii

S0901-5027(16)30102-3

journal_volume

45

pub_type

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