Abstract:
:Increased DNA breaks in aging skeletal muscle activate the DNA-PK pathway, whereas blocking this pathway improves mitochondrial density, physical fitness, body weight, and insulin resistance in mice.
journal_name
Sci Transl Medjournal_title
Science translational medicineauthors
Shoemaker AHdoi
10.1126/scitranslmed.aan4290subject
Has Abstractpub_date
2017-05-17 00:00:00issue
390eissn
1946-6234issn
1946-6242pii
9/390/eaan4290journal_volume
9pub_type
评论,杂志文章abstract::The efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is limited by acute and chronic graft-versus-host disease (GVHD). The impact of obesity on allo-HSCT outcomes is poorly understood. Here, we report that obesity had a negative and selective impact on acute gut GVHD after allo-HSCT in mice w...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aay7713
更新日期:2020-11-25 00:00:00
abstract::Interpandemic or seasonal influenza A, currently subtypes H3N2 and H1N1, exacts an enormous annual burden both in terms of human health and economic impact. Incidence prediction ahead of season remains a challenge largely because of the virus' antigenic evolution. We propose a forecasting approach that incorporates ev...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aan5325
更新日期:2017-10-25 00:00:00
abstract::A skin-penetrant small molecule activates melanin production to protect cells from cancer-inducing ultraviolet damage. ...
journal_title:Science translational medicine
pub_type: 评论,杂志文章
doi:10.1126/scitranslmed.aan8202
更新日期:2017-07-05 00:00:00
abstract::Diseases of failed inflammation resolution are common and largely incurable. Therapeutic induction of inflammation resolution is an attractive strategy to bring about healing without increasing susceptibility to infection. However, therapeutic targeting of inflammation resolution has been hampered by a lack of underst...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3007672
更新日期:2014-02-26 00:00:00
abstract::Advances in health information technology and electronic medical records have the tremendous potential to accelerate translational and clinical research. However, privacy concerns threaten to be a rate-limiting factor. By recognizing and responding to patient privacy concerns, policy-makers, researchers, and informati...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3002037
更新日期:2011-02-09 00:00:00
abstract::Tuberculous meningitis (TBM) is a devastating form of tuberculosis (TB), and key TB antimicrobials, including rifampin, have restricted brain penetration. A lack of reliable data on intralesional drug biodistribution in infected tissues has limited pharmacokinetic (PK) modeling efforts to optimize TBM treatments. Curr...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aau0965
更新日期:2018-12-05 00:00:00
abstract::Graft-versus-host disease (GVHD) is the most common complication of hematopoietic stem cell transplant (HCT). However, our understanding of the molecular pathways that cause this disease remains incomplete, leading to inadequate treatment strategies. To address this, we measured the gene expression profile of nonhuman...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aad3231
更新日期:2015-11-25 00:00:00
abstract::Case fatality rates for severe malaria remain high even in the best clinical settings because antimalarial drugs act against the parasite without alleviating life-threatening inflammation. We assessed the potential for host-directed therapy of severe malaria of a new class of anti-inflammatory drugs, the innate defens...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3003515
更新日期:2012-05-23 00:00:00
abstract::Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening, cutaneous adverse drug reactions that are accompanied by keratinocyte cell death. Dead keratinocytes from SJS/TEN lesions exhibited necrosis, by morphological criteria. Supernatant from peripheral blood mononuclear cells (PBMCs) ...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3008227
更新日期:2014-07-16 00:00:00
abstract::Lung cancer is more deadly than colon, breast, and prostate cancers combined, and treatment improvements have failed to improve prognosis significantly. Here, we identify a critical mediator of lung cancer progression, Rac1b, a tumor-associated protein with cell-transforming properties that are linked to the matrix me...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3004062
更新日期:2012-07-11 00:00:00
abstract::Disease-free infection in HIV-infected adults is associated with human leukocyte antigen-mediated suppression of viremia, whereas in the sooty mangabey and other healthy natural hosts of simian immunodeficiency virus (SIV), viral replication continues unabated. To better understand factors preventing HIV disease, we i...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aag1048
更新日期:2016-09-28 00:00:00
abstract::Whole-genome sequencing of patient DNA can facilitate diagnosis of a disease, but its potential for guiding treatment has been under-realized. We interrogated the complete genome sequences of a 14-year-old fraternal twin pair diagnosed with dopa (3,4-dihydroxyphenylalanine)-responsive dystonia (DRD; Mendelian Inherita...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3002243
更新日期:2011-06-15 00:00:00
abstract::A new type of biological clock regulates the unfolded protein response. ...
journal_title:Science translational medicine
pub_type: 评论,杂志文章
doi:10.1126/scitranslmed.aan6728
更新日期:2017-06-28 00:00:00
abstract::In recent years, there has been a growing focus on the unreliability of published biomedical and clinical research. To introduce effective new scientific contributors to the culture of health care, we propose a "datathon" or "hackathon" model in which participants with disparate, but potentially synergistic and comple...
journal_title:Science translational medicine
pub_type: 杂志文章,评审
doi:10.1126/scitranslmed.aad9072
更新日期:2016-04-06 00:00:00
abstract::MG53 promotes sarcolemmal repair in the mdx mouse model of Duchenne muscular dystrophy (Weisleder et al., this issue) and identifies a new protein therapeutic for muscle disease. ...
journal_title:Science translational medicine
pub_type: 评论,杂志文章
doi:10.1126/scitranslmed.3004082
更新日期:2012-06-20 00:00:00
abstract::About 170 million people worldwide are infected with hepatitis C virus (HCV). The current standard therapy leads to sustained viral elimination in only approximately 50% of the treated patients. Telaprevir, an HCV protease inhibitor, has substantial antiviral activity in patients with chronic HCV infection. However, i...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3000544
更新日期:2010-05-05 00:00:00
abstract::Global investments in health information technology (HIT) in the form of electronic health record systems represent important new strategies to improve the quality and efficiency of health care. These potential benefits of HIT will not be achieved without direct attention to the use of health care information for clin...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3000764
更新日期:2010-02-10 00:00:00
abstract::In 2013, chikungunya virus (CHIKV) transmission was documented in the Western Hemisphere, and the virus has since spread throughout the Americas with more than 1.8 million people infected in more than 40 countries. CHIKV targets the joints, resulting in symmetric polyarthritis that clinically mimics rheumatoid arthrit...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aah3438
更新日期:2017-02-01 00:00:00
abstract::The Wnt signaling pathway plays a central role in bone development and homeostasis. In most cases, Wnt ligands promote bone growth, which has led to speculation that Wnt factors could be used to stimulate bone healing. We gained insights into the mechanism by which Wnt signaling regulates adult bone repair through the...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3000231
更新日期:2010-04-28 00:00:00
abstract::A major obstacle to eradicating polio is that poliovirus from endemic countries can be reintroduced to polio-free countries. Environmental surveillance (ES) can detect poliovirus from sewage or wastewaters samples, even in the absence of patients with paralysis. ES is underused, in part because its sensitivity is unkn...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aaf6786
更新日期:2017-03-29 00:00:00
abstract::MicroRNAs (miRNAs) regulate many aspects of human biology. They target mRNAs for translational repression or degradation through base pairing with 3' untranslated regions, primarily via seed sequences (nucleotides 2 to 8 in the mature miRNA sequence). A number of individual miRNAs and miRNA families share seed sequenc...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3006840
更新日期:2013-11-20 00:00:00
abstract::Acute graft-versus-host disease (aGVHD) results from a robust response of donor T cells transferred during hematopoietic stem cell transplantation (HSCT) to allogeneic peptide-major histocompatibility complex antigens. Previous investigations have not identified T cell subsets that selectively mediate either protectiv...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3005452
更新日期:2013-06-05 00:00:00
abstract::Atherosclerosis is the cause of morbiditiy for 70% of patients with type 2 diabetes. In both of these diseases, a protein complex known as the inflammasome is stimulated to activate interleukin-1β (IL-1β) and IL-18, which are pathogenic inflammatory cytokines. Triggers for the inflammasome are obesity-related factors,...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3001902
更新日期:2011-05-04 00:00:00
abstract::Previous attempts to gain insight into the pathogenesis of psoriasis and eczema by comparing their molecular signatures were hampered by the high interindividual variability of those complex diseases. In patients affected by both psoriasis and nonatopic or atopic eczema simultaneously (n = 24), an intraindividual comp...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3008946
更新日期:2014-07-09 00:00:00
abstract::Nitrogen-containing bisphosphonates (N-BPs), such as alendronate, are the most widely prescribed medications for diseases involving bone, with nearly 200 million prescriptions written annually. Recently, widespread use of N-BPs has been challenged due to the risk of rare but traumatic side effects such as atypical fem...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aav9166
更新日期:2020-05-20 00:00:00
abstract::The elevation of carbon dioxide (CO2) in tissues and the bloodstream (hypercapnia) occurs in patients with severe lung diseases, including chronic obstructive pulmonary disease (COPD). Whereas hypercapnia has been recognized as a marker of COPD severity, a role for hypercapnia in disease pathogenesis remains unclear. ...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aat1662
更新日期:2018-09-05 00:00:00
abstract::In populations that have not been selected for family history of disease, it is unclear how commonly pathogenic variants (PVs) in disease-associated genes for rare Mendelian conditions are found and how often they are associated with clinical features of these conditions. We conducted independent, prospective analyses...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aag2367
更新日期:2016-11-09 00:00:00
abstract::Atherosclerotic lesional macrophages express molecules that promote plaque progression, but lack of mechanisms to therapeutically target these molecules represents a major gap in translational cardiovascular research. Here, we tested the efficacy of a small interfering RNA (siRNA) nanoparticle (NP) platform targeting ...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aay1063
更新日期:2020-07-22 00:00:00
abstract::Long-acting GSK1265744 (GSK744 LA) is a strand transfer inhibitor of the HIV/SIV (simian immunodeficiency virus) integrase and was shown to be an effective preexposure prophylaxis (PrEP) agent in a low-dose intrarectal SHIV (simian-human immunodeficiency virus) rhesus macaque challenge model. We examined the pharmacok...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3010298
更新日期:2015-01-14 00:00:00
abstract::Forty years ago, Judah Folkman predicted that tumor growth is dependent on angiogenesis and that inhibiting this process might be a new strategy for cancer therapy. This hypothesis formed the foundation of a new field of research that represents an excellent example of how a groundbreaking scientific discovery can be ...
journal_title:Science translational medicine
pub_type: 杂志文章,评审
doi:10.1126/scitranslmed.3003149
更新日期:2011-12-21 00:00:00