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Novel benzimidazol-2-ylidene carbene precursors and their silver(I) complexes: Potential antimicrobial agents.

Abstract：

:Novel benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) precursors, these NHC precursors were metallated with Ag2O in dichloromethane at room temperature to give novel silver(I)-NHC complexes. Structures of these benzimidazolium salts and silver(I)-NHC complexes were characterized on the basis of elemental analysis, (1)H NMR, (13)C NMR, IR and LC-MS spectroscopic techniques. A series of benzimidazolium salts and silver(I)-NHC complexes were tested against standard bacterial strains: Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and the fungal strains: Candida albicans and Candida tropicalis. The results showed that benzimidazolium salts inhibited the growth of all bacteria and fungi strains and all silver(I)-NHC complexes performed good activities against different microorganisms.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Kaloğlu M,Kaloğlu N,Özdemir İ,Günal S,Özdemir İ

doi

10.1016/j.bmc.2016.06.004

subject

Has Abstract

pub_date

2016-08-15 00:00:00

pages

3649-56

issue

16

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(16)30421-7

journal_volume

24

pub_type

杂志文章

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