Abstract:
BACKGROUND:Chlamydia trachomatis infection is one of the most common sexually transmitted reported bacterial infections worldwide. The well-known sequelae of chlamydial infection include pelvic inflammatory disease and tubal factor infertility, but the evidence linking C. trachomatis infection and adverse pregnancy outcome is inconsistent and has been largely based on case-control studies with limited study populations. We evaluated this link in a population-based longitudinal biobank health registry setting. METHODS:The association between C. trachomatis major outer membrane protein (MOMP) peptide-specific IgG antibodies and ectopic pregnancy, miscarriage, and preterm delivery was examined in a prospective case-control study nested in the Finnish Maternity Cohort. Ectopic pregnancy and miscarriage cases were identified through the Hospital Discharge Register 1998-2005; cases with preterm deliveries were identified through the Finnish Medical Birth register 1988-2005. Control samples were retrieved from the Finnish Maternity Cohort serum bank. A total of 800 cases of ectopic pregnancy, 800 cases of miscarriage, and 1350 cases of preterm birth were included. Equal number of pregnant women without the outcome diagnosis served as controls. The cases and controls were matched by sampling time, at the serum sampling and postal code district. RESULTS:Antichlamydial IgG antibodies were associated with ectopic pregnancy. Positive antibody levels were found in 21.0% of cases and 14.6% of controls (P = 0.001; odds ratio, 1.56; 95% confidence interval, 1.20-2.03). Previous exposure to C. trachomatis, as indicated by serum antibodies, doubled the risk of ectopic pregnancy within age and was highest among women 35 years or older. Antichlamydial IgG antibody rates between the cases with miscarriage (16.3% in cases vs. 16.8% in controls) or preterm delivery (18.1% vs. 18.1%) and controls did not differ. CONCLUSIONS:Our findings confirm the association between previous exposure to C. trachomatis and ectopic pregnancy. We found no association between C. trachomatis seropositivity and miscarriage or preterm birth.
journal_name
Sex Transm Disjournal_title
Sexually transmitted diseasesauthors
Rantsi T,Joki-Korpela P,Wikström E,Öhman H,Bloigu A,Lehtinen M,Gissler M,Tiitinen A,Paavonen J,Surcel HMdoi
10.1097/OLQ.0000000000000432subject
Has Abstractpub_date
2016-06-01 00:00:00pages
382-7issue
6eissn
0148-5717issn
1537-4521pii
00007435-201606000-00009journal_volume
43pub_type
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journal_title:Sexually transmitted diseases
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pub_type: 杂志文章
doi:10.1097/00007435-198807000-00007
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abstract:BACKGROUND:Patient education upon diagnosis of a sexually transmitted infection (STI) may effect changes in high-risk sexual behavior. OBJECTIVE:Describe emergency department (ED) communication with urban female patients treated for STIs. METHODS:: This secondary analysis of data collected during a study of ED commun...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e318188389b
更新日期:2009-01-01 00:00:00
abstract::During a 35-day period, 32 isolates of Neisseria gonorrhoeae strains were collected by culture from patients with positive nucleic acid amplification test results in Nuuk, Greenland, where ciprofloxacin is the preferred treatment. All isolates were quinolone susceptible, suggesting that resistance is rare. Sampling pa...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.OLQ.0000430780.79488.0f
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:Quinolones have a broad spectrum of antimicrobial activity and are widely used for the treatment of uncomplicated Neisseria gonorrhoeae infections. A dramatic increase in the number of reported N. gonorrhoeae infections as well as quinolone-resistant isolates in Vienna prompted us to investigate the pattern o...
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pub_type: 杂志文章
doi:10.1097/01.olq.0000140019.18390.28
更新日期:2004-10-01 00:00:00
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journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000154501.22566.fa
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abstract::Heretofore most people affected by warts of the oral cavity were children, but during the past decade adults have become the most frequently seen patients with warts in the mouth. The popularity of fellatio among heterosexuals, teenagers, and adults has contributed to the spread of oral warts. Of epidemiologic interes...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
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journal_title:Sexually transmitted diseases
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doi:10.1097/00007435-198601000-00002
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journal_title:Sexually transmitted diseases
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doi:10.1097/00007435-198407000-00010
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-09-01 00:00:00
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journal_title:Sexually transmitted diseases
pub_type: 杂志文章
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journal_title:Sexually transmitted diseases
pub_type: 杂志文章,评审
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更新日期:2012-03-01 00:00:00
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更新日期:2019-02-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1999-03-01 00:00:00
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journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198410001-00011
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journal_title:Sexually transmitted diseases
pub_type: 杂志文章
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更新日期:2006-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1997-07-01 00:00:00
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journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:
更新日期:1983-07-01 00:00:00
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journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:
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