Activities of Lysosomal Enzymes in Alloxan-Induced Diabetes in the Mouse.

Abstract:

:The study investigated a panel of lysosomal enzymes in the liver and kidney tissues in alloxan-induced diabetes in the mouse. The mice were divided into six experimental groups receiving 10% alloxan at a dose of 50 and 75 mg/kg over a period of four, eight, and twelve days; each group was compared with controls receiving 0.9% NaCl. The findings were that diabetes induced by both doses of alloxan was accompanied by significant increases in the lysosomal activities of acid phosphatase and the glycosidases investigated: β-glucuronidase, β-galactosidase, β-glucosidase, and N-acetyl-hexosaminidase. The lysosomal enzyme activity in both liver and kidney cells peaked 12 days after onset of diabetes for most enzymes, at the time when hyperglycemia and hyperinsulinemia already started abating after their peak at 8 days into the course of diabetes. The enzyme activity was in most cases higher with the higher dose of alloxan and thus higher level of glycemia. Lysosomal enzymes degrade glycoconjugates, the molecules that are present in the basement membrane of endothelial cells where they contribute to capillary wall stability. Thus, enhanced activity of these enzymes could presage the progression of diabetic microangiopathy, atherosclerosis, and the development of microvascular complications.

journal_name

Adv Exp Med Biol

authors

Witek B,Rochon-Szmejchel D,Stanisławska I,Łyp M,Wróbel K,Zapała A,Kamińska A,Kołątaj A

doi

10.1007/5584_2017_102

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

73-81

eissn

0065-2598

issn

2214-8019

journal_volume

1040

pub_type

杂志文章
  • Biological Surface Adsorption Index of Nanomaterials: Modelling Surface Interactions of Nanomaterials with Biomolecules.

    abstract::Quantitative analysis of the interactions between nanomaterials and their surrounding environment is crucial for safety evaluation in the application of nanotechnology as well as its development and standardization. In this chapter, we demonstrate the importance of the adsorption of surrounding molecules onto the surf...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-47754-1_8

    authors: Chen R,Riviere JE

    更新日期:2017-01-01 00:00:00

  • Genetic control of the immune response to insulin: its dependence upon a macrophage mediated selection of distinct antigenic sites.

    abstract::The immune response to insulin, in both mouse and guinea pig , is under control of H-linked immune response genes. When immunized with either pork or beef insulin to CFA, both strain 2 and 13 guinea pigs respond by antigen-specific lymphocyte proliferation and synthesis of specific antibody. The specificity of the eli...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-8858-0_26

    authors: Rosenthal AS,Rosenwasser LJ,Baskin BL,Schroer J,Thomas JW,Blake JT

    更新日期:1978-01-01 00:00:00

  • Human Hair: Scaffold Materials for Regenerative Medicine.

    abstract::This chapter reviews the studies of keratin-based biomaterials in the past and discusses the advancement of it in recent years. Keratin, as a protein-based biopolymer, possesses excellent biocompatibility and biodegradability. In addition, keratin has abundant disulfide bonds, which result in its unique and tough stru...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-15-3258-0_14

    authors: Chen IC,Yu J

    更新日期:2020-01-01 00:00:00

  • Computational Inferring of Risk Subpathways Mediated by Dysfunctional Non-coding RNAs.

    abstract::Non-coding RNAs mediated core elements of pathways contributes to the disorder of biological function in diseases. Identification of non-coding RNAs mediated subpathways not only can help for deciphering the pathogenic mechanism of complex diseases, but also can gain insight into the functional roles of non-coding RNA...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-13-0719-5_9

    authors: Xu Y,Zhang Y,Li X

    更新日期:2018-01-01 00:00:00

  • Men Are from Mars, Women Are from Venus: Sex Differences in Insulin Action and Secretion.

    abstract::Sex difference plays a substantial role in the regulation of glucose metabolism in healthy glucose-tolerant humans. The factors which may contribute to the sex-related differences in glucose metabolism include differences in lifestyle (diet and exercise), sex hormones, and body composition. Several epidemiological and...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-319-70178-3_4

    authors: Basu A,Dube S,Basu R

    更新日期:2017-01-01 00:00:00

  • Meiotic Divisions: No Place for Gender Equality.

    abstract::In multicellular organisms the fusion of two gametes with a haploid set of chromosomes leads to the formation of the zygote, the first cell of the embryo. Accurate execution of the meiotic cell division to generate a female and a male gamete is required for the generation of healthy offspring harboring the correct num...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-57127-0_1

    authors: El Yakoubi W,Wassmann K

    更新日期:2017-01-01 00:00:00

  • Microalgae as Solar-Powered Protein Factories.

    abstract::Microalgae have an enormous ecological relevance as they contribute significantly to global carbon fixation. But also for biotechnology microalgae became increasingly interesting during the last decades as many algae provide valuable natural products. Especially the high lipid content of some species currently attract...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-27216-0_16

    authors: Hempel F,Maier UG

    更新日期:2016-01-01 00:00:00

  • Ethanol metabolism, oxygen availability and alcohol induced liver damage.

    abstract::The rates of ethanol oxidation in various species are linked to the rates of general metabolism, and more specifically that of O2 utilization by the liver. After chronic ethanol administration, increased oxidation of ethanol is accompanied by increased total hepatic O2 utilization, as studied in the whole animal, the ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4899-5181-6_22

    authors: Israel Y,Kalant H,Khanna JM,Orrego H,Phillips MJ,Stewart DJ

    更新日期:1977-01-01 00:00:00

  • The central oxytocin pulse generator: a pacemaker for luteolysis.

    abstract::Oxytocin (OT) is released from the neurohypophysis into the jugular vein of sheep in small 1-2 min pulses (ca. 10 pg/ml) in both cyclic and ovariectomized sheep. In intact cycling sheep, additional hour long bursts of OT (up to 200 pg/ml) occur in peripheral blood during luteolysis at intervals of 6 to 9 hrs which app...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:

    authors: McCracken JA,Custer EE,Lamsa JC,Robinson AG

    更新日期:1995-01-01 00:00:00

  • Tau Oligomers.

    abstract::The accumulation of tau filaments in neurons is a pathological hallmark of various neurodegenerative diseases, including Alzheimer's disease. However, it is not the filamentous aggregates themselves, but non-filamentous tau species, tau oligomer, that is thought to be the culprit in tau-mediated neurodegeneration. The...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-32-9358-8_27

    authors: Maeda S,Takashima A

    更新日期:2019-01-01 00:00:00

  • Creating a pro-survival and anti-inflammatory phenotype by modulation of acetylation in models of hemorrhagic and septic shock.

    abstract::Shock, regardless of etiology, is characterized by decreased tissue perfusion resulting in cell death, organ dysfunction, and poor survival. Current therapies largely focus on restoring tissue perfusion through resuscitation but have failed to address the specific cellular dysfunction caused by shock. Acetylation is r...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4419-5638-5_11

    authors: Li Y,Alam HB

    更新日期:2012-01-01 00:00:00

  • Interactions of flavones and other phytochemicals with adenosine receptors.

    abstract::Dietary flavonoids have varied effects on animal cells, such as inhibition of platelet binding and aggregation, inhibition of inflammation, and anticancer properties, but the mechanisms of these effects remain largely unexplained. Adenosine receptors are involved in the homeostasis of the immune, cardiovascular, and c...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4757-5235-9_15

    authors: Jacobson KA,Moro S,Manthey JA,West PL,Ji XD

    更新日期:2002-01-01 00:00:00

  • Effects of tropomyosin deficiency in flight muscle of Drosophila melanogaster.

    abstract::We have studied the structure and function of muscle fibers in which tropomyosin stoichiometry has been reduced by genetic mutation. We used a Drosophila melanogaster flightless mutant Ifm(3)3 and a genetic cross of this mutant with wild type flies to achieve a gradation of tropomyosin gene dosage. We measured the fli...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-2872-2_15

    authors: Molloy J,Kreuz A,Miller R,Tansey T,Maughan D

    更新日期:1993-01-01 00:00:00

  • Structural characterization of contaminants in commercial preparations of melatonin by on-line HPLC-electrospray ionization-tandem mass spectrometry.

    abstract::Three different commercially available melatonin preparations were analyzed by on-line HPLC-electrospray ionization-tandem mass spectrometry. All three samples contained the same impurities at the approximately 0.1-0.5% level of parent melatonin. Based on accurate mass-HPLC-MS and tandem mass spectrometric analyses, t...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-4709-9_99

    authors: Naylor S,Johnson KL,Williamson BL,Klarskov K,Gleich GJ

    更新日期:1999-01-01 00:00:00

  • The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operated Ca2+ Entry.

    abstract::Store-operated Ca2+ entry fulfills a crucial role in controlling Ca2+ signals in almost all cells. The Ca2+-sensing stromal interaction molecule (STIM) proteins in the endoplasmic reticulum (ER) undergo complex conformational changes in response to depleted ER luminal Ca2+, allowing them to unfold and become trapped i...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-57732-6_5

    authors: Nwokonko RM,Cai X,Loktionova NA,Wang Y,Zhou Y,Gill DL

    更新日期:2017-01-01 00:00:00

  • Hormone Therapy in Menopause.

    abstract::As longevity expands, women are spending a third of their existence in menopause and beyond. The vast majority suffer from symptoms that negatively impact their quality of life. Systemic vasomotor symptoms (VMS) are the classic cluster affecting 80% of peri- and post-menopausal women. Once thought to be relatively bri...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-38474-6_6

    authors: Paciuc J

    更新日期:2020-01-01 00:00:00

  • The complete enzymic hydrolysis of crosslinked proteins.

    abstract::Procedures used for the complete enzymic hydrolysis of proteins are reviewed. The successful application of complete enzymic hydrolysis in the detection of naturally occurring isopeptide crosslinks and various other types of chemically introduced crosslinks is described. The method may fail if the level of crosslinkin...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4757-9113-6_19

    authors: Milligan B,Holt LA

    更新日期:1977-01-01 00:00:00

  • Roles of RUNX Complexes in Immune Cell Development.

    abstract::During hematopoiesis, a variety of cells are generated from stem cells through successive rounds of cell fate determination processes. Studies in the last two decades have demonstrated the involvement of Runx transcription factor family members in differentiation of multiple types of hematopoietic cells. Along with ev...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-10-3233-2_24

    authors: Ebihara T,Seo W,Taniuchi I

    更新日期:2017-01-01 00:00:00

  • Scleroderma profunda. Clinicopathological studies.

    abstract::Scleroderma profunda represents an unusual clinical entity. There are no unified criteria for its diagnosis. Seven patients with scleroderma profunda were studied. The clinical features can be summarised in three groups: 1. hyperpigmented plaques with subcutaneous induration; 2. erythematous plaques with induration of...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:

    authors: Balabanova M,Obreshkova E

    更新日期:1999-01-01 00:00:00

  • The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.

    abstract::Matching oxygen consumption and supply represents a fundamental challenge to multicellular organisms. HIF-1 is a transcription complex which is emerging as a key mediator of oxygen homeostasis. HIF-1 controls the expression of many genes, including erythropoietin, angiogenic growth factors, glucose transporters and gl...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:

    authors: Maxwell PH,Pugh CW,Ratcliffe PJ

    更新日期:2001-01-01 00:00:00

  • The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status.

    abstract::Most chemical exposures involve complex mixtures. The role of paraoxonase 1 (PON1) and the Q192R polymorphism in the detoxication of individual organophosphorous (OP) compounds has been well-established. The extent to which PON1 protects against a given OP is determined by its catalytic efficiency. We used a humanized...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-60761-350-3_6

    authors: Cole TB,Jansen K,Park S,Li WF,Furlong CE,Costa LG

    更新日期:2010-01-01 00:00:00

  • Studies on selectin-carbohydrate interactions.

    abstract::Recruitment of neutrophils to sites of inflammation is now believed to occur through an initial rolling interaction at the luminal surface of activated endothelium and is mediated by a class of mammalian lectins referred to as the selectins. Selectins recognize carbohydrate determinants on co-receptors. It is generall...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4615-1885-3_31

    authors: Jacob GS,Welply JK,Scudder PR,Kirmaier C,Abbas SZ,Howard SC,Keene JL,Schmuke JJ,Broschat K,Steininger C

    更新日期:1995-01-01 00:00:00

  • Novel Concepts: Langerhans Cells in the Tumour Microenvironment.

    abstract::Langerhans cells (LCs) are immune cells that reside in the stratified epithelium of the skin and mucosal membranes. They play a range of roles in the skin, including antigen presentation and maintenance of peripheral tolerance. Reports of LC numbers have been variable in different cancer types, with the majority of st...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-030-49270-0_8

    authors: Rajesh A,Hibma M

    更新日期:2020-01-01 00:00:00

  • Mammalian mutants genetically altered in CTP synthetase activity.

    abstract::From wildtype mouse lymphoma cells, a clone (FURT-1A), was isolated by virtue of its resistance to 1 microM 5-fluorouracil. In comparative growth rate experiments, FURT-1A cells were also less sensitive than parental cells to the growth inhibitory effects of thymidine, deoxyguanosine, 5-fluorouridine, and arabinosylcy...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4684-1248-2_42

    authors: Aronow B,Ullman B

    更新日期:1986-01-01 00:00:00

  • Epigenetic control of lymphocyte differentiation.

    abstract::Lymphocyte differentiation from haematopoietic stem cells (HSCs) is a multi-step process in which lineage fate choices are made at crucial branch points. Plasticity of common precursors is evidenced by presence of transcriptionally favourable chromatin structures at several lineage-specific loci, making them poised fo...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4419-8216-2_3

    authors: Lopez-Granados E

    更新日期:2011-01-01 00:00:00

  • G-proteins and phospholipase activation in endothelial cells.

    abstract::ATP stimulates arachidonic acid release and prostaglandin biosynthesis (most likely via phospholipase A2 (PLA2) activation) and phospholipase C (PLC) activation in cultured rabbit coronary microvessel endothelial cells. Pertussis toxin pretreatment inhibits ATP stimulated prostaglandin release, but not ATP stimulated ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4684-5805-3_7

    authors: Gerritsen ME,Mannix RJ

    更新日期:1990-01-01 00:00:00

  • Cell-Free Synthesis of Macromolecular Complexes.

    abstract::Cell-free protein synthesis based on E. coli cell extracts has been described for the first time more than 50 years ago. To date, cell-free synthesis is widely used for the preparation of toxic proteins, for studies of the translation process and its regulation as well as for the incorporation of artificial or labeled...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-27216-0_6

    authors: Botte M,Deniaud A,Schaffitzel C

    更新日期:2016-01-01 00:00:00

  • Potential Involvement of Peroxisome in Multiple Sclerosis and Alzheimer's Disease : Peroxisome and Neurodegeneration.

    abstract::Peroxisomopathies are rare diseases due to dysfunctions of the peroxisome in which this organelle is either absent or with impaired activities. These diseases, at the exception of type I hyperoxaluria and acatalasaemia, affect the central and peripheral nervous system. Due to the significant impact of peroxisomal abno...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-030-60204-8_8

    authors: Zarrouk A,Nury T,El Hajj HI,Gondcaille C,Andreoletti P,Moreau T,Cherkaoui-Malki M,Berger J,Hammami M,Lizard G,Vejux A

    更新日期:2020-01-01 00:00:00

  • Therapeutic Antibodies for Biodefense.

    abstract::Diseases can be caused naturally by biological agents such as bacteria, viruses and toxins (natural risk). However, such biological agents can be intentionally disseminated in the environment by a State (military context) or terrorists to cause diseases in a population or livestock, to destabilize a nation by creating...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-72077-7_9

    authors: Avril A

    更新日期:2017-01-01 00:00:00

  • Model systems for studying kisspeptin signalling: mice and cells.

    abstract::Kisspeptins are a family of overlapping neuropeptides, encoded by the Kiss1 gene, that are required for activation and maintenance of the mammalian reproductive axis. Kisspeptins act within the hypothalamus to stimulate release of gonadotrophic releasing hormone and activation of the pituitary-gonadal axis. Robust mod...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4614-6199-9_22

    authors: Colledge WH,Doran J,Mei H

    更新日期:2013-01-01 00:00:00