Role of Mitochondrial Genome Mutations in Pathogenesis of Carotid Atherosclerosis.

abstract：:Xeroderma pigmentosum group A (XPA) is a genetic disorder in DNA nucleotide excision repair (NER) with severe neurological disorders, in which oxidative stress and disturbed melatonin metabolism may be involved. Herein we confirmed the diurnal variation of melatonin metabolites, oxidative stress markers, and antioxida...

journal_title：Oxidative medicine and cellular longevity

authors： Miyata R,Tanuma N,Sakuma H,Hayashi M

更新日期：2016-01-01 00:00:00

abstract：:NADPH oxidase (Nox) is considered a major source of reactive oxygen species (ROS) in the heart in normal and pathological conditions. However, the role of Nox in severe acute pancreatitis- (SAP-) associated cardiac injury remains unclear. Therefore, we aim to investigate the contribution of Nox to SAP-associated cardi...

journal_title：Oxidative medicine and cellular longevity

authors： Wen Y,Liu R,Lin N,Luo H,Tang J,Huang Q,Sun H,Tang L

更新日期：2019-05-09 00:00:00

abstract：:Our previous study showed that proteasomal inhibitor MG132 can prevent diabetic nephropathy (DN) along with upregulation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2). The present study was to investigate whether MG132 can prevent DN in wild-type and Nrf2-KO mice. Type 1 diabetes was induced in wild-type and N...

journal_title：Oxidative medicine and cellular longevity

authors： Kong L,Wang Y,Luo M,Tan Y,Cui W,Miao L

更新日期：2017-01-01 00:00:00

abstract：:Allicin was discussed as an active compound with regard to the beneficial effects of garlic in atherosclerosis. The aim of this study was to investigate the cholesterol-lowering properties of allicin. In order to examine its effects on hypercholesterolemia in male ICR mice, this compound with doses of 5, 10, or 20 mg/...

journal_title：Oxidative medicine and cellular longevity

authors： Lu Y,He Z,Shen X,Xu X,Fan J,Wu S,Zhang D

更新日期：2012-01-01 00:00:00

abstract：:Inhibition of either P2Y12 receptor or the nucleotide-binding oligomerization domain- (NOD-) like receptor pyrin domain containing 3 (NLRP3) inflammasome provides cardioprotective effects. Here, we investigate whether direct NLRP3 inflammasome inhibition exerts additive effects on myocardial protection induced by the ...

journal_title：Oxidative medicine and cellular longevity

authors： Penna C,Aragno M,Cento AS,Femminò S,Russo I,Bello FD,Chiazza F,Collotta D,Alves GF,Bertinaria M,Zicola E,Mercurio V,Medana C,Collino M,Pagliaro P

更新日期：2020-08-03 00:00:00

abstract：Introduction:The omega-3 polyunsaturated fatty acids, as docosahexaenoic acid (DHA), are considered mediators regulating the resolution of inflammation during cancer and may be associated with better outcomes. Epoxydocosapentaenoic acids (EDPs), metabolites of the DHA, are hypothesized to be responsible for some benefi...

journal_title：Oxidative medicine and cellular longevity

authors： Molfino A,Amabile MI,Lionetto L,Spagnoli A,Ramaccini C,De Luca A,Simmaco M,Monti M,Muscaritoli M

更新日期：2019-03-05 00:00:00

abstract：:Curcumin was found to be beneficial in treating several skin pathologies and diseases, providing antioxidant protection due to its reducing properties and its electrophilic properties (the ability to activate the Nrf2 pathway and induce phase II cytoprotective enzymes). Nevertheless, clinical applications of curcumin ...

journal_title：Oxidative medicine and cellular longevity

authors： Ben Yehuda Greenwald M,Frušić-Zlotkin M,Soroka Y,Ben Sasson S,Bitton R,Bianco-Peled H,Kohen R

更新日期：2017-01-01 00:00:00

abstract：:Ischemia-reperfusion injury is the second most common injury of the spinal cord and has the risk of neurological dysfunction and paralysis, which can seriously affect patient quality of life. Salidroside (Sal) is an active ingredient extracted from Herba Cistanche with a variety of biological attributes such as antiox...

journal_title：Oxidative medicine and cellular longevity

authors： Gu C,Li L,Huang Y,Qian D,Liu W,Zhang C,Luo Y,Zhou Z,Kong F,Zhao X,Liu H,Gao P,Chen J,Yin G

更新日期：2020-07-23 00:00:00

abstract：:Serine-threonine kinase receptor-associated protein (STRAP) is a transforming growth factor β (TGF-β) receptor-interacting protein that has been implicated in both cell proliferation and cell death in response to various stresses. However, the precise roles of STRAP in these cellular processes are still unclear. The m...

journal_title：Oxidative medicine and cellular longevity

authors： Manoharan R,Seong HA,Ha H

更新日期：2018-04-19 00:00:00

abstract：:One of the novel interesting topics in the study of cardiovascular disease is the role of the oxidation system, since inflammation and oxidative stress are known to lead to cardiovascular diseases, their progression and complications. During decades of research, many complex interactions between agents of oxidative st...

journal_title：Oxidative medicine and cellular longevity

authors： Kibel A,Lukinac AM,Dambic V,Juric I,Relatic KS

更新日期：2020-12-28 00:00:00

abstract：:Renal ischemia-reperfusion injury (RIRI) refers to a phenomenon associated with dysfunction of the kidney and tissue damage. Unfortunately, no specific drugs have been found that effectively prevent and treat RIRI. Curcumin (Cur), a polyphenol extracted from turmeric, possesses a variety of biological activities invol...

journal_title：Oxidative medicine and cellular longevity

authors： Wang ZH,Deng LH,Chi CW,Wang H,Huang YY,Zheng Q

更新日期：2020-11-12 00:00:00

abstract：Objective:The aim of this study was to establish a 3T3-L1 adipocyte model and ApoE-/- mouse model of intermittent hypoxia (IH) composite abnormal glucose metabolism (AGM) in vitro and in vivo and explore their synergistic damage effect leading to atherosclerosis (AS) and the influence of SREBP-1 signaling molecule-rela...

journal_title：Oxidative medicine and cellular longevity

authors： Ma L,Zhang J,Qiao Y,Sun X,Mao T,Lei S,Zheng Q,Liu Y

更新日期：2019-02-04 00:00:00

abstract：:Exposure to UV light triggers the rapid generation and accumulation of reactive oxygen species (ROS) in skin cells, with consequent increase in oxidative stress and thus in photoaging. Exogenous supplementation with dietary antioxidants and/or skin pretreatment with antioxidant-based lotions before sun exposure might ...

journal_title：Oxidative medicine and cellular longevity

authors： Petruk G,Del Giudice R,Rigano MM,Monti DM

更新日期：2018-08-02 00:00:00

abstract：:To date, it remains unclear whether mild form of acute pancreatitis (AP) may cause myocardial damage which may be asymptomatic for a long time. Pathogenesis of AP-related cardiac injury may be attributed in part to ROS/RNS overproduction. The aim of the present study was to evaluate the oxidative stress changes in bot...

journal_title：Oxidative medicine and cellular longevity

authors： Marciniak A,Walczyna B,Rajtar G,Marciniak S,Wojtak A,Lasiecka K

更新日期：2016-01-01 00:00:00

abstract：:Doxorubicin (DOX) is an efficient chemotherapeutic agent, but its clinical application is limited by its cardiotoxicity associated with increased oxidative stress. Thus, the combination of DOX and antioxidants has been encouraged. In this study, we evaluated (I) the chemical composition and antioxidant capacity of aqu...

journal_title：Oxidative medicine and cellular longevity

authors： Dos Santos JM,Alfredo TM,Antunes KÁ,da Cunha JDSM,Costa EMA,Lima ES,Silva DB,Carollo CA,Schmitz WO,Boleti APA,Dos Santos EL,de Picoli Souza K

更新日期：2018-06-28 00:00:00

abstract：:Lipid metabolism disorder and inflammation are essential promoters in pathogenesis of liver injury in type 2 diabetes. Puerarin (PUR) has been reported to exert beneficial effects on many diabetic cardiovascular diseases and chemical-induced liver injuries, but its effects on diabetic liver injury and its mechanism ar...

journal_title：Oxidative medicine and cellular longevity

authors： Hou B,Zhao Y,Qiang G,Yang X,Xu C,Chen X,Liu C,Wang X,Zhang L,Du G

更新日期：2018-07-02 00:00:00

abstract：:We have demonstrated that neural progenitor cells (NPCs) protect endothelial cells (ECs) from oxidative stress. Since exosomes (EXs) can convey the benefit of parent cells through their carried microRNAs (miRs) and miR-210 is ubiquitously expressed with versatile functions, we investigated the role of miR-210 in the e...

journal_title：Oxidative medicine and cellular longevity

authors： Liu H,Wang J,Chen Y,Chen Y,Ma X,Bihl JC,Yang Y

更新日期：2017-01-01 00:00:00

abstract：:Edaravone (5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, EDV) is a free-radical scavenger reduces organ ischemic injury. Here we investigated whether the protective effects of EDV in renal ischemia/reperfusion (I/R) injury may be enhanced by an EDV derivative bearing a nitric oxide- (NO-) donor furoxan moiety (NO-ED...

journal_title：Oxidative medicine and cellular longevity

authors： Chiazza F,Chegaev K,Rogazzo M,Cutrin JC,Benetti E,Lazzarato L,Fruttero R,Collino M

更新日期：2015-01-01 00:00:00

abstract：:Virulence of enterohemorrhagic Escherichia coli (EHEC) strains depends on production of Shiga toxins. These toxins are encoded in genomes of lambdoid bacteriophages (Shiga toxin-converting phages), present in EHEC cells as prophages. The genes coding for Shiga toxins are silent in lysogenic bacteria, and prophage indu...

journal_title：Oxidative medicine and cellular longevity

authors： Licznerska K,Nejman-Faleńczyk B,Bloch S,Dydecka A,Topka G,Gąsior T,Węgrzyn A,Węgrzyn G

更新日期：2016-01-01 00:00:00

abstract：:Although a growing body of evidence suggests that plant polyphenols can modulate human immune responses, their simultaneous action on monocyte and neutrophil oxidative burst is currently poorly understood. Based on the hypothesis that various polyphenols contained in plant extracts might affect the oxidative burst of ...

journal_title：Oxidative medicine and cellular longevity

authors： Burzynska-Pedziwiatr I,Bukowiecka-Matusiak M,Wojcik M,Machala W,Bienkiewicz M,Spolnik G,Danikiewicz W,Wozniak LA

更新日期：2014-01-01 00:00:00

abstract：:In recent decades, localized tissue oxidative stress has been implicated as a key component in the development of diabetic retinopathy (DR). Increasing evidence shows that oxidative stress caused by diabetes-induced metabolic abnormalities is the most common mechanism associated with the pathogenesis of DR for both ty...

journal_title：Oxidative medicine and cellular longevity

authors： Wu Y,Tang L,Chen B

更新日期：2014-01-01 00:00:00

abstract：:The p75 neurotrophin receptor (p75NTR) is an alpha- and gamma-secretase substrate expressed preferentially in the cholinergic neurons of the nucleus basalis of Meynert, the hippocampus, and the cerebellum of the adult brain. Mutations of the gamma-secretase, presenilin, have been implicated in familial Alzheimer's dis...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang T,Mi Z,Schor NF

更新日期：2009-09-01 00:00:00

abstract：:Bushen Tiansui Formula (BSTSF) is a traditional Chinese medicine prescription. It has been widely applied to treat Alzheimer's disease (AD) in the clinic; however, the mechanisms underlying its effects remain largely unknown. In this study, we used a rat AD model to study the effects of BSTSF on cognitive performance,...

journal_title：Oxidative medicine and cellular longevity

authors： Yi M,Zhang C,Zhang Z,Yi P,Xu P,Huang J,Peng W

更新日期：2020-06-19 00:00:00

abstract：OBJECTIVES:The goal of this study is to describe modifiable lifestyle variables associated with reduced rate of Parkinson's disease (PD) progression. METHODS:The patient-reported outcomes in PD (PRO-PD) were used as the primary outcome measure, and a food frequency questionnaire (FFQ) was used to assess dietary intake...

journal_title：Oxidative medicine and cellular longevity

authors： Mischley LK,Lau RC,Bennett RD

更新日期：2017-01-01 00:00:00

abstract：:Objectives. Oxidative stress contributes to Parkinson's disease (PD) pathophysiology and progression. The objective was to describe central and peripheral metabolites of redox metabolism and to describe correlations between glutathione (Glu) status, age, and disease severity. Methods. 58 otherwise healthy individuals ...

journal_title：Oxidative medicine and cellular longevity

authors： Mischley LK,Standish LJ,Weiss NS,Padowski JM,Kavanagh TJ,White CC,Rosenfeld ME

更新日期：2016-01-01 00:00:00

abstract：:Muscular dystrophies are inherited myogenic disorders accompanied by progressive skeletal muscle weakness and degeneration. Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy and is caused by mutations in the gene that encodes the cytoskeletal protein dystrophin. The treatment f...

journal_title：Oxidative medicine and cellular longevity

authors： Kuno A,Horio Y

更新日期：2016-01-01 00:00:00

abstract：:Transient receptor potential (TRP) proteins consist of a superfamily of cation channels that have been involved in diverse physiological processes in the brain as well as in the pathogenesis of neurological disease. TRP channels are widely expressed in the brain, including neurons and glial cells, as well as in the ce...

journal_title：Oxidative medicine and cellular longevity

authors： Wang R,Tu S,Zhang J,Shao A

更新日期：2020-09-04 00:00:00

abstract：:Transient receptor potential vanilloid 1 (TRPV1) is a Ca+2-permeable channel expressed on neuronal and nonneuronal cells, known as an oxidative stress sensor. It plays a protective role in bacterial infection, and recent findings indicate that this receptor modulates monocyte populations in mice with malaria; however,...

journal_title：Oxidative medicine and cellular longevity

authors： Pereira DMS,Teixeira SA,Murillo O,Peixoto EPM,Araújo MC,Sousa NCF,Monteiro-Neto V,Calixto JB,Cunha TM,Marinho CRF,Muscará MN,Fernandes ES

更新日期：2019-05-16 00:00:00

abstract：:Autophagy is upregulated in spinal cord ischemia reperfusion (SCIR) injury; however, its expression mechanism is largely unknown; moreover, whether autophagy plays a neuroprotective or neurodegenerative role in SCIR injury remains controversial. To explore these issues, we created an SCIR injury rat model via aortic a...

journal_title：Oxidative medicine and cellular longevity

authors： Xie L,Yu S,Yang K,Li C,Liang Y

更新日期：2017-01-01 00:00:00

abstract：:Ulcerative colitis (UC) is a common inflammatory bowel disease that can destroy the integrity of the colon and increase the risk of colorectal cancer. Oxidative stress is one of the critical pathogenic factors for UC, further impairing the entire affected colon. The Nrf2-ARE signaling pathway plays an important role i...

journal_title：Oxidative medicine and cellular longevity

authors： Xu LL,Liu T,Wang L,Li L,Wu YF,Li CC,Di B,You QD,Jiang ZY

更新日期：2018-05-20 00:00:00