The use of high-dose lidocaine in wetting solutions for lipoplasty.

Abstract:

:The use of lidocaine as a local anesthetic has been limited to 7 mg/kg. The authors question whether amounts of lidocaine greater than the recommended dosage may be safely used in the patient undergoing lipoplasty of the torso and knees. Six patients were used as a sample and a wetting solution of 750 mg or 1,000 mg of a .25% lidocaine solution containing 1:400,000 epinephrine was injected into the surgical site. The ratios of milligrams of lidocaine to kilograms of body weight varied from 9.1 to 13.8. Serum lidocaine levels were measured at frequent intervals. Because of many factors, including poor vascularity of subcutaneous fat, vasoconstrictive effect of epinephrine, and aspiration of a portion of the lidocaine, blood levels of lidocaine in the patients never exceeded 1.0 microgram%. We conclude that lidocaine, 9 to 14 mg/kg, results in peak serum lidocaine levels of only 0.5 to 0.8 microgram%.

journal_name

Ann Plast Surg

authors

Lewis CM,Hepper T

doi

10.1097/00000637-198904000-00004

subject

Has Abstract

pub_date

1989-04-01 00:00:00

pages

307-9

issue

4

eissn

0148-7043

issn

1536-3708

journal_volume

22

pub_type

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