An alternative model of vascularized bone marrow transplant: partial femur transplantation.

Abstract:

:The vascularized whole femur transplantation model is one of the commonly used vascularized bone marrow transplant models. It involves technical complexity and morbidities. To optimize this model, we took 2/3 femur as the carrier of bone marrow cells, and developed a vascularized partial femur model. Four experimental groups were carried out, namely, the syngeneic partial femur transplantation, allogeneic partial femur transplantation with or without cyclosporine A, and allogeneic whole femur transplantation with cyclosporine A. The results showed that the partial femur model was technically simpler and shortened the operative and ischemia time compared to the whole femur model. Gross and histologic appearance confirmed the viability of femur, and its bone marrow inside the bone could also maintain normal morphologically at 60-day posttransplant. Besides, donor multilineage chimerism could be continuously detected in immunosuppressed allogeneic partial femur recipients at 1-, 2-, 3-, 4-, and 8-week posttransplant, and it showed no significant differences when compared with whole femur transplantation. Meanwhile, long-term engraftment of donor-origin cells was also confirmed in recipients' bone marrow, lymph nodes, and spleen, but not in thymus. Therefore, the vascularized partial femur can serve as a continuous resource of bone morrow cells and may provide a useful tool for the study of immune tolerance in vascularized composite allotransplantation.

journal_name

Ann Plast Surg

authors

Chen JW,Chen C,Su YJ,Yan L,Wang SP,Guo SZ

doi

10.1097/SAP.0000000000000114

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

710-5

issue

6

eissn

0148-7043

issn

1536-3708

journal_volume

73

pub_type

杂志文章
  • The effect of rigid internal fixation on cranial growth.

    abstract::As the use of rigid internal fixation of the facial skeleton has become routine in adults, many craniofacial surgeons have expanded its use to the pediatric population. The effects of miniplate and screw fixation on subsequent craniofacial growth, however, have not been examined. Using 6-week-old rabbits as an experim...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-199011000-00005

    authors: Resnick JI,Kinney BM,Kawamoto HK Jr

    更新日期:1990-11-01 00:00:00

  • Approach to venous thromboembolism prophylaxis: are we evolving fast enough in plastic surgery?

    abstract::Venous thromboembolism has become a target for research by the American Society of Plastic Surgery. The current article reviews the steps that plastic surgeons and the American Society of Plastic Surgery have taken for creating guidelines in our field. We summarized the current reported incidences of venous thromboemb...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SAP.0b013e3181e35c79

    authors: Clavijo-Alvarez JA,Rubin JP

    更新日期:2011-03-01 00:00:00

  • Median sternotomy wound complication: the effect of reconstruction on lung function.

    abstract::The objective of the study was to evaluate the lung function of patients with median sternotomy wound complication during the early postmedian sternotomy period and to compare the long-term pulmonary effects of reconstruction using pectoralis major and rectus abdominis muscle flaps. The percentage of predicted, standa...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-199707000-00006

    authors: Cohen M,Yaniv Y,Weiss J,Greif J,Gur E,Wertheym E,Shafir R

    更新日期:1997-07-01 00:00:00

  • The effects of suturing technique and vessel size on patency after microarterial repair.

    abstract::According to most of the literature, sutures for microarterial repair must include the intima to prevent an "intimal flap" and occlusion of the anastomosis. Some authors have said that vessel diameter affects patency rate. This study was designed to evaluate these two statements. The femoral arteries (about 1.0 mm in ...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-197903000-00010

    authors: Wray RC,O'Brien BM

    更新日期:1979-03-01 00:00:00

  • Free posterior tibial perforator-based flaps.

    abstract::Free posterior tibial perforator-based flaps, fed by a perforator from the posterior tibial artery, were applied in 2 patients. The advantages of this flap are that they are reliable, relatively large and thin flaps, making it possible to use an innervated flap without sacrificing the posterior tibial artery. This fla...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-199103000-00012

    authors: Koshima I,Soeda S

    更新日期:1991-03-01 00:00:00

  • Recurrent basal cell carcinoma in margin-positive tumors.

    abstract::The purpose of this investigation was (1) to determine the incidence of basal cell carcinoma (BCC) recurrence in patients who had microscopic evidence of residual tumor at the margin of resection and (2) to identify morphological characteristics that predispose to recurrence. Twenty-nine patients with margin-positive ...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-199703000-00008

    authors: Friedman HI,Williams T,Zamora S,al-Assaad ZA

    更新日期:1997-03-01 00:00:00

  • Medial epicanthoplasty without a vertical scar.

    abstract:BACKGROUND:The epicanthal fold (Mongolian fold) in Asians reduces the aesthetic results of eyelid surgery, and thus, medial epicanthoplasty is commonly performed in combination with a double fold operation or blepharoptosis correction. Epicanthoplasty is one of the most popular cosmetic operations conducted in Asia, bu...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0b013e31826eabbc

    authors: Park DH,Park SU,Lee BK,Lee YB,Do ER,Han DG,Shim JS,Lee YJ

    更新日期:2014-07-01 00:00:00

  • Malignant fibrous histiocytoma of the hand: multimodal therapy and extensor tendon reconstruction.

    abstract::A patient with malignant fibrous histiocytoma of the dorsum of the hand, managed with irradiation and wide local excision, is presented. Biopsy technique, the rationale for preoperative irradiation, and the details of extensor tendon reconstruction are discussed. Tendon grafts, rather than transfers, were used to reco...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-199811000-00016

    authors: Lohman R,Evans GR

    更新日期:1998-11-01 00:00:00

  • The use of validated body image indices following panniculectomy.

    abstract::Limited data of body image and quality of life are available after panniculectomy. Although it is generally considered a medically necessary procedure, we believe that the benefits of this procedure are many. The Short Form of The Situational Inventory of Body Image Dysphoria Short Form and the Multidimensional Body S...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0b013e31820b3af6

    authors: Singh KA,Losken A

    更新日期:2011-05-01 00:00:00

  • Transient postoperative stenosis in small-vessel anastomoses.

    abstract::Using a newly developed Doppler probe, we have found that a standard suture anastomosis in a rat femoral artery is accompanied by significant (30-60%) cross-sectional area stenosis, which dissipates to baseline levels within 24 hours. We hypothesized that spasm, deposition of coagulation products, or the suture techni...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-199503000-00015

    authors: Moskovitz MJ,Zhang L,Baron DA,Kanner BJ,Tuchler RE,Siebert JW

    更新日期:1995-03-01 00:00:00

  • Useful arterialized flaps for head and neck reconstruction.

    abstract::During the past 10 years, there have been extensive developments in both "island" muscle and musculocutaneous flaps and in "free" microvascular transfers. Competition still exists between these two schools of surgical methodology, even though both methods are known to be complementary and have comparable success rates...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000637-198710000-00012

    authors: Posnick JC,McCraw JB

    更新日期:1987-10-01 00:00:00

  • Splinting After Ear Reconstruction: A Stepwise and Inexpensive Workflow Protocol.

    abstract:BACKGROUND:Long-term postoperative splinting plays a role in the prevention of contracture of the grafted skin after a second-stage ear reconstruction. The scar retraction could lead to an unfavorable aesthetic outcome. Splinting could play a role to overcome or prevent the loss of projection and the obliteration of th...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0000000000001212

    authors: Vercruysse H Jr,Green JIJ,Osman G,Harrison B,Miyagi K,Bulstrode NW

    更新日期:2018-04-01 00:00:00

  • Postauricular Approach for Mandibular Angle Ostectomy: An Alternative for Shortening the Recovery Time.

    abstract::Many surgical procedures to improve mandibular contour have been introduced in East Asia. Despite consensus regarding mandible contouring surgery, surgery which includes angle ostectomy and lateral cortex excision, some patients require only mandibular angle ostectomy. The intraoral approach is a widely used method, b...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0000000000000216

    authors: Lim H,Kang M

    更新日期:2016-01-01 00:00:00

  • Long-term results of midcarpal arthrodesis in the treatment of scaphoid nonunion advanced collapse (SNAC-Wrist) and scapholunate advanced collapse (SLAC-Wrist).

    abstract:UNLABELLED:Outcome evaluation of midcarpal arthrodesis in the treatment of scaphoid nonunion advanced collapse (SNAC-wrist) and scapholunate advanced collapse (SLAC-wrist). PURPOSE:Scaphoid nonunion or scapholunate ligament instability results in carpal collapse and subsequent arthrosis. These conditions, termed SLAC-...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/01.sap.0000194245.94684.54

    authors: Dacho A,Grundel J,Holle G,Germann G,Sauerbier M

    更新日期:2006-02-01 00:00:00

  • Flexor tendon repair in the neonate.

    abstract::Primary or delayed primary repair of flexor tendon lacerations in the digital sheath has become the accepted practice among surgeons expert in the treatment of hand injuries. The youngest patient reported in the literature we reviewed was 3 months old. We report a case of flexor tendon laceration at the time of delive...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-198211000-00011

    authors: Kavouksorian CA,Noone RB

    更新日期:1982-11-01 00:00:00

  • The growth of vascularized onlay bone transfers.

    abstract::The growth of vascularized onlay bone (autogenous) transfers on the skulls of 27 newborn New Zealand white rabbits was studied. Freeze-dried bone weight in control newborns and control adults (group 1) was compared with that in experimental adult animals (group 2). In the experimental group, the bone was transferred o...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-198706000-00008

    authors: LaTrenta GS,McCarthy JG,Cutting CB

    更新日期:1987-06-01 00:00:00

  • Treatment of chronic, nonhealing abdominal wound in a liquid environment.

    abstract::A 66-year-old woman with an abdominal wound caused by infected synthetic mesh had failed to heal in spite of many surgical attempts to close the wound. A sealed transparent vinyl chamber was glued to the periphery of the wound and antibiotics in high concentrations (up to 2,500 times the minimum inhibitory concentrati...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-199601000-00016

    authors: Eriksson E,Perez N,Slama J,Page CP,Andree C,Maguire JH

    更新日期:1996-01-01 00:00:00

  • Microvascular free transfer in reconstruction of the pharynx and cervical esophagus.

    abstract::We present 8 cases of microvascular reconstruction of the pharynx and cervical esophagus using 5 free ileal transfers and 3 radial forearm flaps. One of the skin flaps underwent a delay procedure a month before transfer. All flaps survived, though there were 2 salivary fistulas that healed spontaneously. ...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-199311000-00010

    authors: Vavylov VN,Ushakov VS,Tokarevitch KK,Krasnoumov AN,Kasyanov IV,Semyonov SV

    更新日期:1993-11-01 00:00:00

  • Penis allotransplantation model in the rat.

    abstract::In this study we present the first experimental vascularized penile allogenic transplantation model in the rat. In group 1 (n = 6), the vascular anatomy of the male rat perineal region was determined. In 12 Lewis rats of group 2 (n = 24), the penile composite graft was transplanted as isotransplant by microvascular an...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0b013e31817dc4d8

    authors: Sonmez E,Nasir S,Siemionow M

    更新日期:2009-03-01 00:00:00

  • Alloplastic reconstruction of large cranio-orbital defects: a comparative evaluation.

    abstract::Norian CRS, Bone Cement (Synthes CMF), and Mimix (Lorenz) have been used to reconstruct large cranio-orbital defects in 85 patients. Resorbable mesh (Macropore), used in combination in selected patients, obviates dura pulsations that have been postulated to cause fragmentation of alloplastic material. Norian is compos...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/01.sap.0000168157.10664.9c

    authors: Greenberg BM,Schneider SJ

    更新日期:2005-07-01 00:00:00

  • Heel reconstruction with an iliac osteocutaneous free flap: 10-year follow-up.

    abstract::During the Homeland War in Croatia, many civilians suffered from war wounds of the extremities. Explosive war wounds create composite and devastating injuries mainly by high-energy transfer to the tissue. We present an early reconstruction of explosive heel wound with an iliac osteocutaneous free flap with late follow...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/01.sap.0000099704.02280.d6

    authors: Stanec Z,Krivić A,Stanec S,ZIc R,Budi S

    更新日期:2004-08-01 00:00:00

  • Precaruncular approach for the reconstruction of medial orbital wall fractures.

    abstract::To reconstruct medial orbital wall fractures with a clear, least dissection, an alternative method, precaruncular approach, has been performed. We reviewed 36 patients with medial blowout fractures treated with this technique. The incision was made between the caruncle and medial canthal skin at the mucocutaneous junc...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0b013e31826a1a75

    authors: You HJ,Kim DW,Dhong ES,Yoon ES

    更新日期:2014-01-01 00:00:00

  • Isolated Dorsoradial Capsular Tear of the Thumb Metacarpophalangeal Joint: Missed Diagnosis and the Management of Delayed Presentation.

    abstract::Isolated dorsoradial capsule injuries of the thumb metacarpophalangeal joint are different from those associated with collateral ligament disruption. Early suspicion of this rare injury is important because, if overlooked, ulnarward subluxation of extensor pollicis longus tendon can develop. Functionally, active thumb...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0000000000001202

    authors: Godwin Y,Ter Horst B,Scerri G

    更新日期:2018-02-01 00:00:00

  • Inframammary fold reconstruction with a deepithelialized skin flap.

    abstract::Sagging of the remaining breast behind the inframammary fold after breast reduction or breast augmentation may necessitate revisional surgery. The authors achieved inframammary fold reconstruction by reconstruction of the inframammary crease ligament through a deepithelialized skin flap that is anchored to the periost...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/01.SAP.0000037279.69711.53

    authors: Wechselberger G,Del Frari B,Pülzl P,Schoeller T

    更新日期:2003-04-01 00:00:00

  • V-Y in V-Y procedure: new technique for augmentation and protrusion of the upper lip.

    abstract::A new surgical technique for upper lip augmentation is presented. In this technique, 2 vertically parallel V-shaped incisions placed in a "V in V" fashion are used. Remarkable augmentation of the lip is provided by V-to-Y closure of the incisions. Over 7 years, this new technique, namely, V-Y in V-Y procedure, was use...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/01.sap.0000205774.40210.58

    authors: Mutaf M

    更新日期:2006-06-01 00:00:00

  • Successful Treatment of Plantar Hyperkeratosis in the Form of Recurrent Corns With Split-Thickness Sole Skin Graft.

    abstract:INTRODUCTION:Plantar hyperkeratosis, such as corns and calluses, is common in older people and associated with pain, mobility impairment, and functional limitations. It usually develops on the palms, knees, or soles of feet, especially under the heels or balls. There are several treatment methods for plantar hyperkerat...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0000000000001304

    authors: Wang CY,Chang CK,Chou CY,Wu CJ,Chu TS,Chiao HY,Chen CY,Chen TM,Tzeng YS

    更新日期:2018-02-01 00:00:00

  • Long-term survival in basal cell carcinoma metastatic to bone: a case report.

    abstract::A total of 97 cases of metastatic basal cell carcinoma have been reported in the literature, 22 of which were metastatic to bone. To date there has been no survival following bone metastasis. A case report of significant long-term survival--over three times the expected--is presented. The treatment described is perhap...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-197912000-00010

    authors: Briggs RM,Pestana I

    更新日期:1979-12-01 00:00:00

  • Angiographic analysis of the first metatarsal arteries and its clinical applications.

    abstract::Twenty-five feet (18 patients) plus 2 traumatically amputated feet were used for angiographic analysis of the first metatarsal arteries. The author classified the first (dorsal and plantar) metatarsal arteries into three types: the first dorsal metatarsal artery, dominant type (seen in 17 feet), the first plantar meta...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-198107000-00002

    authors: Ohtsuka H

    更新日期:1981-07-01 00:00:00

  • Effect of electrosurgical technique on wound healing and early complication rate following abdominal dermolipectomy.

    abstract::Thirty-eight patients with significant weight loss after vertical banded gastroplasty were studied prospectively while undergoing abdominal dermolipectomy to determine if the current intensity used during electrosurgical dissection influenced wound complication rates after this surgery. Patients were assigned randomly...

    journal_title:Annals of plastic surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000637-199609000-00002

    authors: Kuzon WM Jr,Crawford R,Binhammer P,Fielding C,Knowlton R,Levine R

    更新日期:1996-09-01 00:00:00

  • The Impact of Microbial Communities on Wound Healing: A Review.

    abstract::Chronic, nonhealing wounds place an enormous burden on both the health care system and patients, with no definitive treatments available. There has been increasing evidence that the microbial composition of wounds may play an important role in wound healing. Culture-independent methods for bacterial detection and anal...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SAP.0000000000001450

    authors: Xu Z,Hsia HC

    更新日期:2018-07-01 00:00:00