Abstract:
:Chronic, nonhealing wounds place an enormous burden on both the health care system and patients, with no definitive treatments available. There has been increasing evidence that the microbial composition of wounds may play an important role in wound healing. Culture-independent methods for bacterial detection and analysis have revealed the wound microbiome to be much more diverse and complex than culture alone. Such methods primarily rely on targeted amplification and sequencing of various hypervariable regions of the bacterial 16S rRNA for phylogenetic analysis. To date, there have been several studies utilizing culture-independent methods to investigate the microbiome of a variety of chronic wounds, including venous insufficiency ulcers, pressure ulcers, and diabetic foot ulcers. Major bacteria found include Staphylococcus, Streptococcus, Corynebacterium, Pseudomonas, and various anaerobes. Current studies suggest that improved healing and outcomes may be correlated with increased bacterial diversity and instability of the microbiome composition of a wound. However, the exact role of the microbiome in wound healing remains poorly understood. While the current research is promising, studies are very heterogeneous, hindering comparisons of findings across different research groups. In addition, more studies are needed to correlate microbiome findings with clinical factors, as well as in the relatively unexplored fields of acute wounds and nonbacterial microbiomes, such as the wound mycobiome and virome. Better understanding of the various aspects of the microorganisms present in wounds may eventually allow for the manipulation of the wound microbiota in such a way as to promote healing, such as through bacteriophage therapies or probiotics.
journal_name
Ann Plast Surgjournal_title
Annals of plastic surgeryauthors
Xu Z,Hsia HCdoi
10.1097/SAP.0000000000001450subject
Has Abstractpub_date
2018-07-01 00:00:00pages
113-123issue
1eissn
0148-7043issn
1536-3708journal_volume
81pub_type
杂志文章,评审abstract::Idiopathic avascular necrosis of the scaphoid, or Preiser disease, is a rare condition. Both the etiology and the pathology are still not well understood. We here present 2 cases with this disease and discuss the recommended treatment according to the stage of disease progression and by reference to previous studies i...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/SAP.0b013e31827fafa1
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Chronic ischemia of the hand in the setting of atherosclerotic disease is a challenging problem that leads to serial amputations and significant morbidity. Salvage using an in situ venous bypass has been described. In selected cases, leaving the vein in situ for bypass allows a good size match for anastomosi...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000761
更新日期:2016-06-01 00:00:00
abstract::Breast reconstruction after nipple sparing mastectomy (NSM) plays, nowadays, a fundamental role in breast cancer management. There is no consensus on the best implant-based reconstruction technique, considering 2 stages (expander-prosthesis) or direct-to-implant (DTI). A retrospective review of consecutive adult femal...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001893
更新日期:2019-10-01 00:00:00
abstract::The optic nerve can be injured indirectly by blunt trauma to the frontoorbital region. The mechanism of injury is related to trauma of the nerve in the tight, bony optic canal. Neurovisual transmission in the canal is interrupted by pressure on the nerve. The conventional management includes careful observation and su...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-197811000-00011
更新日期:1978-11-01 00:00:00
abstract::We present a case of a nail defect, which was reconstructed by free composite nail combined with the palmar pocket method without vascular anastomoses. A 40-year-old man lost his nail of the right middle finger by trauma 1 year ago. A total nail composite graft, composed of germinal and sterile matrices, and proximal ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000164731.99795.fe
更新日期:2005-06-01 00:00:00
abstract::Lipofibromatosis is a slow-growing, childhood soft-tissue neoplasm that is often confused with other conditions. We report a patient with lipofibromatosis causing extremity enlargement at birth. The lesion initially was thought to be a vascular anomaly or lipedema on clinical and MRI examination. When involving the lo...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3181a13df6
更新日期:2009-06-01 00:00:00
abstract::Controversy exists on whether or not the epidermal keratinizing squamous epithelium of skin grafts and flaps applied to line a neovagina changes histologically to a nonkeratinizing mucosal type squamous epithelium after vaginoplasty in male-to-female transsexuals. To end this discussion, the aim of this study was to o...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000258953.00234.50
更新日期:2007-11-01 00:00:00
abstract::Despite intense research, etiologies underlying syndromic craniosynostosis remain poorly understood. While syndrome-related genetic factors have garnered much attention, external forces likely play a large role as well. In contrast to well-defined genetic abnormalities that may be precisely identified and statisticall...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31815d5c14
更新日期:2008-09-01 00:00:00
abstract::We have developed a new in vivo model for the study of fetal wound healing. Fetal ICR mice (total gestation, 21 days) received a full-thickness incisional wound in the hind limb at gestational day 14 (N = 100). The wound was made with a 28.5-gauge needle that was passed transplacentally into the amniotic cavity. The w...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199710000-00008
更新日期:1997-10-01 00:00:00
abstract::During the past 10 years, there have been extensive developments in both "island" muscle and musculocutaneous flaps and in "free" microvascular transfers. Competition still exists between these two schools of surgical methodology, even though both methods are known to be complementary and have comparable success rates...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/00000637-198710000-00012
更新日期:1987-10-01 00:00:00
abstract::A study of the psychological aspects of mastectomy and reconstruction was carried out. A review of the literature revealed varied emotional responses to the mastectomy experience. An initial, limited study was designed to investigate the attitudes of two groups of women, one that chose reconstruction after mastectomy ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198407000-00008
更新日期:1984-07-01 00:00:00
abstract::Pilar leiomyoma is a benign smooth muscle tumor arising from the arrectores pili muscles associated with the hair follicles of the skin. The multiple biopsies and pathological consultations needed to obtain a diagnosis attest to the rarity of the disease and the difficult histological picture, which often requires an ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/00000637-200045060-00018
更新日期:2000-12-01 00:00:00
abstract::To evaluate the management and outcome of acute facial powder burns, 10 patients admitted to a burn center (1980-1985) were reviewed. Facial burns resulted from black gun-powder in 7 and fireworks in 3 patients. Most burns occurred in teenage boys (6) and all but 1 were the result of carelessness on the part of the bu...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198708000-00009
更新日期:1987-08-01 00:00:00
abstract::Repair of unilateral cleft lip is a challenging procedure with no single technique satisfactory for all types of unilateral cleft deformity. This study compares retrospectively five techniques of unilateral cleft lip repair in 72 children (45 boys, 27 girls). Twenty-two children had a Millard rotation-advancement repa...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199812000-00002
更新日期:1998-12-01 00:00:00
abstract::Using a newly developed Doppler probe, we have found that a standard suture anastomosis in a rat femoral artery is accompanied by significant (30-60%) cross-sectional area stenosis, which dissipates to baseline levels within 24 hours. We hypothesized that spasm, deposition of coagulation products, or the suture techni...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199503000-00015
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:The reported rate of isolated medial orbital wall fractures varies widely but has been found to be as high as 55% of all orbital fractures. Identifying and repairing medial orbital wall defects by using appropriate materials improves patient outcome considerably; however, most related research has focused on...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001012
更新日期:2017-03-01 00:00:00
abstract::Congenital segmental amputations are difficult to correct. Free interposition bone grafts with growth centers were tried experimentally by many investigators even at the beginning of this century. Attempts at clinical application of this principle, however, were mostly failures. More recently, with the advent of micro...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199210000-00010
更新日期:1992-10-01 00:00:00
abstract::The reconstruction of scalp defects presents a clinical challenge. Free tissue transfer has played an increasingly important role in the reconstruction of complex scalp defects. In many cases, patient medical comorbidities along with the length of the operative procedures incurs significant patient risk. Artificial de...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318180c913
更新日期:2009-06-01 00:00:00
abstract::Basal cell carcinoma is the most common type of malignant cutaneous neoplasm found in man. Rarely, however, is it life-threatening or does it metastasize. A review of the literature revealed 138 cases of metastatic basal cell carcinoma. We describe 3 additional patients with metastatic basal cell carcinoma who were tr...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198312000-00017
更新日期:1983-12-01 00:00:00
abstract::Microvascular reconstruction at the lower extremity for complex composite wounds has traditionally been predicated upon performance of the microanastamosis beyond the so-called "zone of injury." Failure to do so was believed to account for increased rates of vessel thrombosis and transplant loss. Extensive vessel diss...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199603000-00007
更新日期:1996-03-01 00:00:00
abstract::The nasal reconstruction in 8 patients and cheek reconstruction in 1 using a free flap from the deltoid region has been successfully undertaken in our department since August 1987. The flap has a direct cutaneous artery--the acromial artery--as its vascular axis. The experiences and a brief anatomical review of the do...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198907000-00003
更新日期:1989-07-01 00:00:00
abstract::A young male patient, who sustained a severe burn injury 6 years ago, received amputation of left hand at the level of metacarpal shaft of the thumb and base of proximal phalanxes of the rest of the fingers. Staged operations, including combined second- and third-toe transfer from the right foot to middle and ring fin...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002200
更新日期:2020-01-01 00:00:00
abstract::Oronasal fistula formation is a recalcitrant complication following palatoplasty, resulting in nasal emission during speech and deglutition. We review our series to identify factors associated with fistula incidence. A retrospective review of all children with nonsyndromic cleft palate who underwent 2-flap palatoplast...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318199669b
更新日期:2009-12-01 00:00:00
abstract:INTRODUCTION:Plastic surgeons are often asked to assist with the reconstruction of lower extremity wounds. These patients many times require free tissue transfer for coverage given paucity of soft tissue. Anecdotally, many orthopedic surgeons prefer muscle coverage--particularly in the setting of potentially infected b...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000779
更新日期:2016-05-01 00:00:00
abstract::Glomus tumors develop from a thermoregulatory unit called the glomus body which is found in high density within the digits of both the hands and feet. To note, even though less frequently, these tumors can present in extradigital locations. Usually it presents as a small, 1-cm bluish nodule. Glomangioma (multiple glom...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000222729.59856.e1
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Concerns of nonlasting results and potential nasal growth damage precluded cleft nasal correction at the time of initial cleft lip repair. Our goal was to evaluate the outcome of primary cleft nasal correction in our patients with unilateral cleft lip. METHODS:A retrospective review of patients with complet...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002039
更新日期:2020-01-01 00:00:00
abstract::A short operative time and a high successful rate of microvascular anastomosis are the goals of many plastic surgeons. The authors present their experimental and clinical experience in microvascular anastomoses with the use of a combination of continuous suture and interrupted tie. Twenty rats were divided into two gr...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200045030-00010
更新日期:2000-09-01 00:00:00
abstract::Tissue engineering is an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function. This field has enjoyed tremendous growth in the past 10 years fuelled by its potential role in regenerating ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/SAP.0b013e3181788ec9
更新日期:2009-01-01 00:00:00
abstract::A 4-year-old girl was referred to the plastic surgery unit with metastatic malignant melanoma diagnosed in a cervical lymph node. She had previously undergone excision of a Spitz nevus of the cheek at age 18 months. The management of this patient is discussed along with a review of the literature relating to Spitz nev...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.SAP.0000037277.03962.4F
更新日期:2003-05-01 00:00:00
abstract::Reconstruction of complex tissue deficiencies in which each missing component is in a different spatial relationship to each other can be particularly challenging, especially in patients with limited recipient vessels. The chimera flap design is uniquely suited to reconstruct these deformities. Chimera flaps have been...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/SAP.0b013e318193499f
更新日期:2009-10-01 00:00:00