Abstract:
:We have developed a new in vivo model for the study of fetal wound healing. Fetal ICR mice (total gestation, 21 days) received a full-thickness incisional wound in the hind limb at gestational day 14 (N = 100). The wound was made with a 28.5-gauge needle that was passed transplacentally into the amniotic cavity. The wounds were analyzed histologically on postoperative days 0, 1, 3, and 5 by hematoxylin-eosin and Mallory's trichrome stains. Once the wounding technique was mastered, the overall mortality rate for this model was 20% by postwounding day 5. Each fetus healed their wound without scar by postwounding day 3. In 3 animals, 5 microliters of human transforming growth factor beta 1 (25 micrograms per microliter) was injected into the wound site, resulting in scar and an inflammatory cell infiltrate, indicating that the 14-day-gestation fetal mouse can be manipulated if necessary. This model offers the advantages of an in vivo system that can be studied at an early gestational age. Furthermore, it is inexpensive, easy to manipulate, and can be studied with commercially available murine probes.
journal_name
Ann Plast Surgjournal_title
Annals of plastic surgeryauthors
Stelnicki EJ,Bullard KM,Harrison MR,Cass DL,Adzick NSdoi
10.1097/00000637-199710000-00008subject
Has Abstractpub_date
1997-10-01 00:00:00pages
374-80issue
4eissn
0148-7043issn
1536-3708journal_volume
39pub_type
杂志文章abstract::An approach to outpatient anesthesia using drugs that have reversible or very short-acting effects is described, along with a method of monitoring patients using pulse rate to assess tranquility. Preoperatively, the patient is given 1 mg of lorazepam the evening before surgery and sublingual lorazepam 1 mg combined wi...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198012000-00013
更新日期:1980-12-01 00:00:00
abstract:BACKGROUND:Since obtaining FDA approval for postsurgical pain management in 2011, a number of well-designed studies have reported favorably on the safety and efficacy of liposomal bupivacaine (LB). However, the literature lacks adequate reports of patient perception of postoperative pain and subjective satisfaction. M...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000444
更新日期:2015-06-01 00:00:00
abstract::How and why aponeurotic blepharoptosis develops was investigated in terms of the relationship between the levator aponeurosis and Mueller's muscle functioning as the muscle spindle of the levator muscle. A total of 200 consecutive patients with moderate to severe acquired blepharoptosis completed questionnaires regard...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200101000-00006
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Lower eyelid malposition is the most common complication after lower eyelid blepharoplasty. Although the traditional techniques were effective for correcting lower eyelid malposition, they had potential disadvantages, including additional trauma, additional scar, and long recovery period. OBJECTIVE:To evalu...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318248b65f
更新日期:2013-07-01 00:00:00
abstract::Breast deformities following long-lasting complications associated with the use of polyurethane prostheses are encountered with increasing frequency in our practice. Patients with this problem often feel frustrated after a long period of unsuccessful treatment and multiple operations. The anatomopathological bases of ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199006000-00003
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:Pulmonary complications are common among patients who have undergone major oral cancer surgery with microvascular reconstruction. Current literatures focused on early-onset pneumonia in the postoperative acute stage. In contrast, we are aiming to identify the clinical importance and the risk factors associat...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002170
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Extensive orbital floor and medial wall fractures compared with isolated orbital wall fractures are more likely to require surgical correction because of a higher possibility of complications like diplopia, enophthalmos, or numbness. The unique and complex contours of the orbital anatomy limit th...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001700
更新日期:2019-01-01 00:00:00
abstract::Xeroderma pigmentosum is a relatively rare systemic disease transmitted through an incomplete sex-linked recessive gene. It is characterized by malignant skin degeneration. One of the most effective treatment choices for the malignant changes is full-face resurfacing with skin grafts. Grafts harvested from areas that ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract:PURPOSE:An increase in bariatric surgery has led to a rise in postbariatric contouring procedures. Despite a comprehensive preoperative assessment, body habitus in these patients may significantly limit the abdominal exam. Abdominal contouring procedures typically elevate large portions of the skin and fat off the abdo...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001546
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:This study aimed to present the results of a series of forequarter amputations (FQAs) and to evaluate the reconstructive methods used. SUMMARY BACKGROUND DATA:Although FQA has become a rare procedure in the era of limb-sparing treatment of extremity malignancies, it is a useful option when resection of a sho...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002204
更新日期:2020-06-01 00:00:00
abstract::There is general agreement that Dupuytren's contracture is a genetic disorder that occurs predominantly in white men of Northern European ancestry. It appears rarely in the purely black population. We present our experience from Temple University of 8 black patients with Dupuytren's contracture. We also present a revi...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/00000637-199406000-00010
更新日期:1994-06-01 00:00:00
abstract::A subjective description of a technique of immediate reconstruction of cutaneous defects due to laceration is presented. Extension of the use and range of the Z-plasty is emphasized and its benefits and limitations are discussed. The reconstructive surgeon is challenged to consider wider and more frequent use of these...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-197809000-00003
更新日期:1978-09-01 00:00:00
abstract:BACKGROUND:Patients with unilateral cleft lip and palate (CLP) deformities commonly develop nasal airway obstruction, necessitating septoplasty at the time of definitive rhinoplasty. We assessed the contribution of the bony septum to airway obstruction using computed tomography (CT) and cone beam CT (CBCT). METHODS:A ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000027
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:This study of stage III (locally advanced) breast cancer patients evaluated the survival improvement conferred by immediate breast reconstruction by transverse rectus abdominis musculocutaneous (TRAM) flap reconstruction after modified radical mastectomy (MRM) in comparison with MRM alone. METHODS:This retr...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000251
更新日期:2014-09-01 00:00:00
abstract::The purpose of our retrospective study was to evaluate the outcomes of scaphoid fracture nonunion treated with a pronator quadratus pedicled vascularized bone graft and a headless compression screw with regard to early wrist and thumb mobilization. From January 2008 to June 2011, 27 patients (20 men and 7 women; mean ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000025
更新日期:2015-06-01 00:00:00
abstract::Island skin flaps based on the latissimus dorsi muscle were raised in domestic pigs. Flap circulation, maintained only by the vascular pedicle, was monitored by laser Doppler flowmetry, laser photometry, and transcutaneously measured carbon dioxide tension. Both arterial and venous occlusion were accompanied by very l...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198501000-00005
更新日期:1985-01-01 00:00:00
abstract::A mild, persistent umbilical hernia that does not cause any functional problem is often ignored. The authors have devised a new technique to treat the mild, protrusive deformity of the umbilicus without associated complications. In this report, the new operative procedure is introduced. The authors have treated 72 pat...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199906000-00009
更新日期:1999-06-01 00:00:00
abstract::Upper thoracic wounds with exposed hardware from spinal instrumentation and previous radiation presents a subset of back wound coverage problems that lend themselves to a unique opportunity to use the distal trapezius musculocutaneous flap. The unradiated, healthy skin paddle can be transposed between the radiated ski...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.SAP.0000054242.00928.06
更新日期:2003-07-01 00:00:00
abstract::This study evaluated the outcomes of extensor indicis proprius (EIP) transfer based on varying degrees of thumb extension after EIP transfer and elongation of the EIP. A total of 24 cases with extensor pollicis longus (EPL) ruptures who underwent EIP to EPL transfer were analyzed prospectively. The EIP transfer was pe...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,随机对照试验
doi:10.1097/SAP.0000000000000593
更新日期:2015-12-01 00:00:00
abstract::The objective of the study was to evaluate the lung function of patients with median sternotomy wound complication during the early postmedian sternotomy period and to compare the long-term pulmonary effects of reconstruction using pectoralis major and rectus abdominis muscle flaps. The percentage of predicted, standa...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199707000-00006
更新日期:1997-07-01 00:00:00
abstract::Although the etiology of nonsyndromic forms of craniosynostosis remains uncertain, recent experiments from our laboratory have demonstrated that fetal head constraint induces cranial suture fusion in mice through a process associated with altered patterns of transforming growth factor beta (TGF-beta) isoform expressio...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200105000-00015
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Quality of life and functional improvement have emerged as important goals for patients with oncologic disease. For patients with head and neck cancer, free anterolateral thigh (ALT) flaps serve as reliable reconstruction and provide functional restoration. Nevertheless, factors affecting the resumption of o...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002652
更新日期:2021-02-01 00:00:00
abstract:INTRODUCTION:Calcium gluconate extravasation is a process, which, while not common, occurs more frequently in neonatal intensive care units. The aim of this study is to present a number of cases of calcium gluconate extravasation, which have occurred in our hospital, and to carry out a review of those clinical cases pu...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/SAP.0000000000001110
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:Autologous breast reconstruction with abdominally based free flaps has traditionally been associated with a longer hospital stay and higher initial cost relative to other reconstructive methods. One important component of this course is postoperative pain control. Thoracic epidural anesthesia is considered amon...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002423
更新日期:2020-12-01 00:00:00
abstract::Suction-assisted lipectomy (SAL) in association with abdominoplasty has been regarded with trepidation, with ischemia of the apron flap, skin loss, and open wounds among the potential dire consequences. Leaving midabdominal and epigastric fatty excess, however, confers suboptimal contour and often a mediocre cosmetic ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31816f76d6
更新日期:2008-05-01 00:00:00
abstract:INTRODUCTION:Human placental membranes (hPMs) have a long history in treating burns and wounds. The composition of hPMs includes structural matrix, growth factors, and neonatal cells, all of which contribute to their regenerative potential. However, most hPM products are devitalized after dehydration and irradiation. W...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001101
更新日期:2017-08-01 00:00:00
abstract::A muscle bow traction method was developed for dynamic facial reanimation utilizing the masseter muscle and a fascial sling. The principle of this method is that the sling around the muscle pulls the oral commissure laterally and backward by the restoring force of the muscle from its relaxed position to its contracted...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199910000-00002
更新日期:1999-10-01 00:00:00
abstract::Ischemia/reperfusion injury (IRI) after free tissue transfer of the small intestine results in transmural tissue damage. This study examined the effects of IRI on the jejunum. Wistar rats served either as controls (N=10) or underwent clamping of the infrarenal aorta for 1 hour followed by 1 hour of reperfusion (N=10)....
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199806000-00008
更新日期:1998-06-01 00:00:00
abstract:PURPOSE:This study aimed to describe immediate nasal reconstruction using a forehead flap after dog bite injuries. BACKGROUND:Dog bites to the nose can avulse multiple aesthetic subunits, making primary repair difficult, inadvisable, or impossible. Microsurgical replantation and composite grafting of the nose have bee...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31827ead6c
更新日期:2013-04-01 00:00:00
abstract::From an anatomical standpoint, the support of the inferior two thirds of the nose is ensured by the cartilaginous septum. Usually, the reconstruction of total loss of the quadrangular cartilage is performed with some success by means of camouflage procedures such as L-shaped struts or cantilever grafts. In this articl...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199506000-00010
更新日期:1995-06-01 00:00:00