Abstract：
:To ascertain whether zearalenone (ZEA) could induce intestinal inflammation and investigate its possible mechanism, we investigated inflammatory cytokine release and the activation of the NLRP3 inflammasome after ZEA treatment both in vitro or in vivo. First, intestinal porcine enterocyte cell line (IPEC-J2) cells and mouse peritoneal macrophages were treated with ZEA to detect NLRP3 inflammasome activation, and the role of reactive oxygen species (ROS) in ZEA-induced inflammation was investigated. Then, Balb/c mice were fed a gavage of ZEA, and the disease activity indices (DAIs) and histological analysis were used to assess intestinal inflammation. Our study showed that the mRNA expression of NLRP3 inflammasome, pro-interleukin-1β (pro-IL-1β), and pro-interleukin-18 (pro-IL-18) was up-regulated 0.5- to 1-fold and that the release of IL-1β and IL-18 increased from 48 pg mL-1 to 55 pg mL-1 and 110 pg mL-1 to 145 pg mL-1, respectively. However, ROS inhibitor N-acetyl-l-cysteine (NAC) reduced IL-1β and IL-18 release to 45 pg mL-1 and 108 pg mL-1. Moreover, the same phenomenon was observed in intestinal tissues of ZEA-treated mice. In addition, clinical parameters of treated mice showed stools became loose and contained mucous. In addition, the presence of gross blood stool was found in the last 2 d. Histological analysis showed obvious inflammatory cell infiltration and tissue damage in the colon. These findings uncovered a possible mechanism of intestinal mucosal innate immunity in response to mycotoxin ZEA that ZEA could activate the ROS-mediated NLRP3 inflammasome and, in turn, contribute to the caspase-1-dependent activation of the inflammatory cytokines IL-1β and IL-18.
journal_name
Chemospherejournal_title
Chemosphereauthors
Fan W,Lv Y,Ren S,Shao M,Shen T,Huang K,Zhou J,Yan L,Song Sdoi
10.1016/j.chemosphere.2017.09.145subject
Has Abstractpub_date
2018-01-01 00:00:00pages
272-279eissn
0045-6535issn
1879-1298pii
S0045-6535(17)31567-9journal_volume
190pub_type
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