Abstract：
BACKGROUND:Intracranial hemorrhage is a common complication of traumatic brain injury (TBI). The purpose of this study is evaluation of the effect of tranexamic acid (TXA) on hemorrhagic mass growth in TBI patients. PATIENTS AND METHODS:In this randomized, double-blind clinical trial, 149 patients with TBI and any kind of blood on their computed tomography scan enrolled in the study and were randomly allocated to receive TXA or placebo. After 24 hours, computed tomography scan was repeated for assessing the changes in hemorrhage, new bleeding, and mass effects of blood on brain tissue. The primary outcome was growth of the hemorrhagic lesion. Data were analyzed by SPSS software using Fisher exact, chi-square, and Mann-Whitney U tests, as well as linear and logistic regression models. FINDINGS:The incidence of hemorrhagic lesion growth was 20.5% in the TXA group and 22.7% in the placebo group. The difference was not significant (P = 0.87, RR = 0.89). The mean (standard deviation) of hemorrhagic lesion growth was 9.4 (15.3) in the TXA group and 10.2 (10.1) in the placebo group without significant difference (P = 0.27). The frequency of deaths (2.7% vs. 4%), adverse outcome at discharge (10.8% vs. 17.3%), and 3 months later (6.8% vs. 14.7%) in the TXA group were lower than the placebo, but the difference was not statistically significant. No side effect was observed with the administration of TXA. CONCLUSION:Administration of a short dose of TXA does not lead to significant prevention of growth of posttraumatic hemorrhagic lesion or improvement of clinical outcomes.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Fakharian E,Abedzadeh-Kalahroudi M,Atoof Fdoi
10.1016/j.wneu.2017.10.075subject
Has Abstractpub_date
2018-01-01 00:00:00pages
e748-e753eissn
1878-8750issn
1878-8769pii
S1878-8750(17)31803-Xjournal_volume
109pub_type
杂志文章,随机对照试验abstract：OBJECTIVE:High-mobility group box 1 (HMGB1) was shown to be a major extracellular mediator involved in relayed neuro-inflammation in animals after subarachnoid hemorrhage (SAH). It is of interest to examine the effect of rhinacanthin-C (RCT-C, C25H30O5) on pro-inflammatory cytokines/HMGB1 in an SAH-related early brain ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.08.071
更新日期：2016-02-01 00:00:00
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journal_title：World neurosurgery
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更新日期：2020-11-01 00:00:00
abstract：OBJECTIVE:To determine the impact of the 2019 novel coronavirus disease (COVID-19) pandemic on operative case volume in 8 U.S. neurosurgical residency training programs in early 2020 and to survey these programs regarding training activities during this period. METHODS:A retrospective review was conducted of monthly o...
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journal_title：World neurosurgery
pub_type： 杂志文章
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.03.098
更新日期：2019-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-12-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2018.11.042
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Cement leakage is the most common complication of vertebroplasty and kyphoplasty. So far, the reported risk factors remain conflicting because of limited data and lack of uniform measurement and evaluation. Here, we performed a systematic review and meta-analysis of potential risk factors for cement leakage ...
journal_title：World neurosurgery
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.wneu.2017.01.124
更新日期：2017-05-01 00:00:00
abstract：:The National Hospital, Queen Square, London was founded as a charitable institution in 1860, becoming the first dedicated neuroscience hospital in the world. Sir Victor Horsley, the first neurosurgeon was appointed in 1886, and since that time, Queen Square neurosurgeons have been prominent on the World neurosurgical ...
journal_title：World neurosurgery
pub_type： 历史文章,杂志文章
doi：10.1016/j.wneu.2017.02.021
更新日期：2017-07-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.07.224
更新日期：2019-11-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.07.221
更新日期：2018-11-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2018.12.015
更新日期：2018-12-19 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.10.043
更新日期：2018-01-01 00:00:00
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更新日期：2017-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.wneu.2019.03.044
更新日期：2019-07-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2011.09.022
更新日期：2013-03-01 00:00:00
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journal_title：World neurosurgery
pub_type：
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更新日期：2020-03-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.04.129
更新日期：2020-08-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.10.204
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更新日期：2018-05-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.06.016
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journal_title：World neurosurgery
pub_type： 杂志文章,评审
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更新日期：2020-08-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.05.108
更新日期：2018-08-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,评审
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更新日期：2019-09-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.05.025
更新日期：2018-08-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.10.006
更新日期：2021-01-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
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更新日期：2020-02-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.09.170
更新日期：2019-01-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2010.04.005
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVE:Thrombectomy with aspiration catheters has shown to be effective for treatment of intracranial large vessel occlusion (LVO). We present preclinical evaluation of the safety and efficacy of React68 and React71 (Medtronic PLC, Irvine, CA) catheters in animal models of LVO. METHODS:In vivo evaluation of cathete...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.08.131
更新日期：2019-12-01 00:00:00
