Abstract:
BACKGROUND:Antidepressant use is highly prevalent. Research has mainly focused on efficacy during short periods of use for depression and anxiety. There is a relative paucity of data regarding the frequency of long-term use. METHODS:To determine the prevalence and possible increase of long-term use of antidepressants over recent years, we analyzed routine general practice care data in a large cohort of patients (n = 156,620) in and around Amsterdam, The Netherlands. Additionally, predictors of long-term use were studied. RESULTS:Prevalence of long-term use of antidepressants is substantial, and such use appears to be increasing: 30.3% of use was long-term over the period 1995-2005 compared to 43.7% for the period 2005-2015. Higher age, a registered diagnosis of anxiety or depression, and the use of SSRIs or SNRIs were associated with long-term use in multivariate analysis. In addition, specific antidepressants were differentially associated with long-term use. CONCLUSIONS:Long-term antidepressant use is substantial and appears to be on the rise. Awareness of this phenomenon should be increased, such use should be prevented when possible, and reasons for long-term use need to be examined.
journal_name
Psychother Psychosomjournal_title
Psychotherapy and psychosomaticsauthors
Huijbregts KM,Hoogendoorn A,Slottje P,van Balkom AJLM,Batelaan NMdoi
10.1159/000480456subject
Has Abstractpub_date
2017-01-01 00:00:00pages
362-369issue
6eissn
0033-3190issn
1423-0348pii
000480456journal_volume
86pub_type
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journal_title:Psychotherapy and psychosomatics
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journal_title:Psychotherapy and psychosomatics
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journal_title:Psychotherapy and psychosomatics
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journal_title:Psychotherapy and psychosomatics
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journal_title:Psychotherapy and psychosomatics
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更新日期:1993-01-01 00:00:00
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更新日期:1985-01-01 00:00:00
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更新日期:2016-01-01 00:00:00
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更新日期:1989-01-01 00:00:00
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更新日期:2010-01-01 00:00:00
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