当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > Cardiovascular Risks of Probenecid Versus Allopurinol in Older Patients With Gout.

Cardiovascular Risks of Probenecid Versus Allopurinol in Older Patients With Gout.

Abstract：

BACKGROUND:Patients with gout are at an increased risk of cardiovascular (CV) disease including myocardial infarction (MI), stroke, and heart failure (HF). OBJECTIVES:The authors conducted a cohort study to examine comparative CV safety of the 2 gout treatments-probenecid and allopurinol-in patients with gout. METHODS:Among gout patients ≥65 years of age and enrolled in Medicare (2008 to 2013), those who initiated probenecid or allopurinol were identified. The primary outcome was a composite CV endpoint of hospitalization for MI or stroke. MI, stroke, coronary revascularization, HF, and mortality were assessed separately as secondary outcomes. The authors estimated the incidence rate and hazard ratio of the primary and secondary outcomes in the 1:3 propensity score-matched cohort of probenecid and allopurinol initiators. RESULTS:A total of 9,722 probenecid initiators propensity score-matched to 29,166 allopurinol initiators with mean age of 76 ± 7 years, and 54% males were included. The incidence rate of the primary composite endpoint of MI or stroke per 100 person-years was 2.36 in probenecid and 2.83 in allopurinol initiators with a hazard ratio of 0.80 (95% confidence interval: 0.69 to 0.93). In the secondary analyses, probenecid was associated with a decreased risk of MI, stroke, HF exacerbation, and mortality versus allopurinol. These results were consistent in the subgroup analyses of patients without baseline CV disease or those without baseline chronic kidney disease. CONCLUSIONS:In this large cohort of 38,888 elderly gout patients, treatment with probenecid appears to be associated with a modestly decreased risk of CV events including MI, stroke, and HF exacerbation compared with allopurinol.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Kim SC,Neogi T,Kang EH,Liu J,Desai RJ,Zhang M,Solomon DH

doi

10.1016/j.jacc.2017.12.052

subject

Has Abstract

pub_date

2018-03-06 00:00:00

pages

994-1004

issue

9

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(18)30026-3

journal_volume

71

pub_type

杂志文章

相关文献

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY文献大全
  • Multislice computed tomography for detection of patients with aortic valve stenosis and quantification of severity.

    abstract：OBJECTIVES:The purpose of this study was to evaluate whether multislice computed tomography (MSCT) provides a reliable, noninvasive imaging modality for identification of patients with degenerative aortic valve stenosis (AS) by quantifying the aortic valve area (AVA) in comparison to the accepted diagnostic standard tr...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2005.11.056

    authors： Feuchtner GM,Dichtl W,Friedrich GJ,Frick M,Alber H,Schachner T,Bonatti J,Mallouhi A,Frede T,Pachinger O,zur Nedden D,Müller S

    更新日期：2006-04-04 00:00:00

  • The antioxidant N-2-mercaptopropionyl glycine attenuates left ventricular hypertrophy in in vivo murine pressure-overload model.

    abstract：OBJECTIVES:In order to identify the role of reactive oxygen species (ROS) in cardiac hypertrophy, we examined the effect of N-2-mercaptopropionyl glycine (MPG) on cardiac hypertrophy. BACKGROUND:Recent in vitro studies have suggested that ROS play an important role as a second messenger in cardiac hypertrophy. It was ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(01)01826-5

    authors： Date MO,Morita T,Yamashita N,Nishida K,Yamaguchi O,Higuchi Y,Hirotani S,Matsumura Y,Hori M,Tada M,Otsu K

    更新日期：2002-03-06 00:00:00

  • Asynchronous atrioventricular valve opening as it relates to right to left interatrial shunting in the normal newborn.

    abstract：:The opening of the tricuspid valve and the onset of right ventricular filling precede the opening of the mitral valve and the onset of flow in the normal adult. Sixty-five studies of atrioventricular flow with range-gated pulsed Doppler echocardiography, performed on 32 normal neonates, consistently demonstrated the r...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(88)80062-7

    authors： Steinfeld L,Almeida OD,Rothfeld EL

    更新日期：1988-09-01 00:00:00

  • Symptomatic myocardial bridges: overview of ischemic mechanisms and current diagnostic and treatment strategies.

    abstract：:This review article focuses on the morphological and functional alterations that characterize patients with myocardial bridges (MB) as well as the currently available diagnostic and treatment strategies. Because of incomplete understanding of the pathophysiology of MB, their clinical significance has been the subject ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/s0735-1097(02)02768-7

    authors： Bourassa MG,Butnaru A,Lespérance J,Tardif JC

    更新日期：2003-02-05 00:00:00

  • Myocardial strain and torsion quantified by cardiovascular magnetic resonance tissue tagging: studies in normal and impaired left ventricular function.

    abstract：:Accurate quantification and timing of regional myocardial function allows early identification of dysfunction, and therefore becomes increasingly important for clinical risk assessment, patient management, and evaluation of therapeutic efficacy. For this purpose, the application of tissue Doppler echocardiography has ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2006.07.048

    authors： Götte MJ,Germans T,Rüssel IK,Zwanenburg JJ,Marcus JT,van Rossum AC,van Veldhuisen DJ

    更新日期：2006-11-21 00:00:00

  • Value of acceleration flow signals proximal to the leaking orifice in assessing the severity of prosthetic mitral valve regurgitation.

    abstract：:To test the value of acceleration flow signals proximal to the leaking orifice in assessing the severity of prosthetic mitral valve regurgitation, 39 consecutive patients undergoing left ventriculography were examined by Doppler color flow imaging. Acceleration flow signals proximal to the regurgitant orifice were det...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(92)90487-8

    authors： Yoshida K,Yoshikawa J,Akasaka T,Nishigami K,Minagoe S

    更新日期：1992-02-01 00:00:00

  • Failed direct coronary angioplasty for acute myocardial infarction: in-hospital outcome and predictors of death.

    abstract：OBJECTIVES:The purpose of this study was to compare the mechanisms, predictors and outcome of patients with failed direct coronary angioplasty of the infarct-related artery with those in patients with successful direct angioplasty. BACKGROUND:Direct coronary angioplasty of the infarct-related artery, without anteceden...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(93)90178-4

    authors： Bedotto JB,Kahn JK,Rutherford BD,McConahay DR,Giorgi LV,Johnson WL,O'Keefe JH,Shimshak TM,Ligon RW,Hartzler GO

    更新日期：1993-09-01 00:00:00

  • Effect of pravastatin on angiographic restenosis after coronary balloon angioplasty. The PREDICT Trial Investigators. Prevention of Restenosis by Elisor after Transluminal Coronary Angioplasty.

    abstract：OBJECTIVES:This study sought to determine whether pravastatin affects clinical or angiographic restenosis after coronary balloon angioplasty. BACKGROUND:Experimental data and preliminary clinical studies suggest that lipid-lowering drugs might have a beneficial effect on restenosis after coronary angioplasty. METHODS...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0735-1097(97)00259-3

    authors： Bertrand ME,McFadden EP,Fruchart JC,Van Belle E,Commeau P,Grollier G,Bassand JP,Machecourt J,Cassagnes J,Mossard JM,Vacheron A,Castaigne A,Danchin N,Lablanche JM

    更新日期：1997-10-01 00:00:00

  • Endothelial vasomotor dysfunction in the brachial artery is associated with late in-stent coronary restenosis.

    abstract：OBJECTIVES:This study examined whether endothelial dysfunction in the brachial artery might be associated with late in-stent restenosis (ISR) after percutaneous coronary intervention (PCI). BACKGROUND:Simple and noninvasive identification of late ISR might help to select patients who require further angiographic evalu...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2005.04.055

    authors： Kitta Y,Nakamura T,Kodama Y,Takano H,Umetani K,Fujioka D,Saito Y,Kawabata K,Obata JE,Ichigi Y,Mende A,Kugiyama K

    更新日期：2005-08-16 00:00:00

  • Use of color kinesis for evaluation of left ventricular filling in patients with dilated cardiomyopathy and mitral regurgitation.

    abstract：OBJECTIVES:We tested the feasibility of using analysis of color kinesis images to objectively assess global and regional left ventricular (LV) diastolic function in patients with dilated cardiomyopathy (DCM). In addition, the ability of this technique to track drug-induced changes on LV diastolic properties was studied...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(98)00144-2

    authors： Godoy IE,Mor-Avi V,Weinert L,Vignon P,Korcarz C,Spencer KT,Lang RM

    更新日期：1998-06-01 00:00:00

  • Induction of local angiotensin II-producing systems in stenotic aortic valves.

    abstract：OBJECTIVES:The purpose of this study was to investigate the expression of angiotensin II (Ang II)-producing enzyme systems in normal and stenotic aortic valves. BACKGROUND:Chronic inflammation and fibrosis are involved in the pathogenesis of aortic stenosis (AS), but the detailed molecular mechanisms of this atheroscl...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.jacc.2004.07.054

    authors： Helske S,Lindstedt KA,Laine M,Mäyränpää M,Werkkala K,Lommi J,Turto H,Kupari M,Kovanen PT

    更新日期：2004-11-02 00:00:00

  • Outcomes of Cancer Patients Undergoing Percutaneous Pericardiocentesis for Pericardial Effusion.

    abstract：BACKGROUND:Pericardial effusion (PE) is common in cancer patients, but the optimal therapeutic approach is not well defined. Percutaneous pericardiocentesis is less invasive than surgery, but its long-term effectiveness and safety have not been well documented. OBJECTIVES:The goal of this study was to evaluate outcome...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2015.06.1332

    authors： El Haddad D,Iliescu C,Yusuf SW,William WN Jr,Khair TH,Song J,Mouhayar EN

    更新日期：2015-09-08 00:00:00

  • Long-term effects of surgical septal myectomy on survival in patients with obstructive hypertrophic cardiomyopathy.

    abstract：OBJECTIVES:This study sought to determine the impact of surgical myectomy on long-term survival in hypertrophic cardiomyopathy (HCM). BACKGROUND:Left ventricular (LV) outflow tract obstruction in HCM increases the likelihood of heart failure and cardiovascular death. Although surgical myectomy is the primary treatment...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2005.02.090

    authors： Ommen SR,Maron BJ,Olivotto I,Maron MS,Cecchi F,Betocchi S,Gersh BJ,Ackerman MJ,McCully RB,Dearani JA,Schaff HV,Danielson GK,Tajik AJ,Nishimura RA

    更新日期：2005-08-02 00:00:00

  • ACC/AHA Versus ESC/ESH on Hypertension Guidelines: JACC Guideline Comparison.

    abstract：:This study compares the recommendations of the most recent American College of Cardiology (ACC)/American Heart Association (AHA) and European Society of Cardiology (ESC)/European Society of Hypertension (ESH) blood pressure guidelines. Both guidelines represent updates of previous guidelines and reinforce previous con...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2019.03.507

    authors： Bakris G,Ali W,Parati G

    更新日期：2019-06-18 00:00:00

  • Inhibition of atherosclerosis by fish oil in cholesterol-fed rabbits.

    abstract：:To evaluate the effects of dietary fish oil on cholesterol-induced atherosclerosis, 36 New Zealand rabbits in four groups were fed a 0.3% cholesterol diet for 10 weeks. One group served as control, whereas groups I, II and III received 1, 2 and 3 ml/day, respectively, of fish oil (Protochol, eicosapentaenoic acid, 180...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(88)90478-0

    authors： Zhu BQ,Smith DL,Sievers RE,Isenberg WM,Parmley WW

    更新日期：1988-10-01 00:00:00

  • Accurate estimates of absolute left ventricular volumes from equilibrium radionuclide angiographic count data using a simple geometric attenuation correction.

    abstract：:To simplify and clarify the methods of obtaining attenuation-corrected equilibrium radionuclide angiographic estimates of absolute left ventricular volumes, 27 patients who also had biplane contrast cineangiography were evaluated. Background-corrected left ventricular end-diastolic and end-systolic counts were obtaine...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(84)80256-9

    authors： Starling MR,Dell'Italia LJ,Walsh RA,Little WC,Benedetto AR,Nusynowitz ML

    更新日期：1984-03-01 00:00:00

  • Prognostic value of N-terminal proatrial natriuretic factor plasma levels measured within the first 12 hours after myocardial infarction. Thrombolysis in Myocardial Infarction (TIMI) II Investigators.

    abstract：OBJECTIVES:The aim of the present study was to examine the relation between the plasma levels of the atrial peptide N-terminal proatrial natriuretic factor (proANF) measured during the 1st 12 h after myocardial infarction and 1-year mortality. BACKGROUND:The atrial peptides atrial natriuretic factor and N-terminal pro...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(95)00342-8

    authors： Hall C,Cannon CP,Forman S,Braunwald E

    更新日期：1995-11-15 00:00:00

  • Comparison of dual-chamber pacing versus septal myectomy for the treatment of patients with hypertrophic obstructive cardiomyopathy: a comparison of objective hemodynamic and exercise end points.

    abstract：OBJECTIVES:The purpose of this study was to compare the treatment effects of septal myectomy with dual-chamber pacing in patients with hypertrophic obstructive cardiomyopathy (HOCM). BACKGROUND:The optimal treatment for symptomatic patients with drug-refractory HOCM is unknown. Both dual-chamber pacing and surgical my...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(99)00173-4

    authors： Ommen SR,Nishimura RA,Squires RW,Schaff HV,Danielson GK,Tajik AJ

    更新日期：1999-07-01 00:00:00

  • Independent and incremental value of coronary artery calcium for predicting the extent of angiographic coronary artery disease: comparison with cardiac risk factors and radionuclide perfusion imaging.

    abstract：OBJECTIVES:The study was done to test the ability to predict the extent of angiographically determined coronary artery disease (CAD) by quantification of coronary calcium using electron-beam computed tomography (EBCT) and to compare it with more conventional parameters for delineating the angiographic extent of CAD, th...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(99)00265-x

    authors： Schmermund A,Denktas AE,Rumberger JA,Christian TF,Sheedy PF 2nd,Bailey KR,Schwartz RS

    更新日期：1999-09-01 00:00:00

  • Antimyosin scintigraphy and immunohistologic analysis of endomyocardial biopsy in patients with clinically suspected myocarditis--evidence of myocardial cell damage and inflammation in the absence of histologic signs of myocarditis.

    abstract：OBJECTIVES:This study compares the results of antimyosin scintigraphy in patients with clinically suspected myocarditis with histologic and immunohistologic findings in the endomyocardial biopsy. BACKGROUND:In patients with clinically suspected myocarditis, antimyosin scintigraphy often demonstrates myocardial cell da...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(98)00397-0

    authors： Kühl U,Lauer B,Souvatzoglu M,Vosberg H,Schultheiss HP

    更新日期：1998-11-01 00:00:00

  • Myocardial contrast echocardiography in humans. II. Assessment of coronary blood flow reserve.

    abstract：:The hypothesis that myocardial contrast echocardiography could be used to simultaneously assess coronary blood flow reserve and the size of the perfusion bed supplied by a coronary artery was examined in nine patients and six dogs. All patients were undergoing cardiac catheterization and had single vessel coronary art...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(88)90456-1

    authors： Keller MW,Glasheen W,Smucker ML,Burwell LR,Watson DD,Kaul S

    更新日期：1988-10-01 00:00:00

  • Cholesterol-lowering interventions and stroke: insights from a meta-analysis of randomized controlled trials.

    abstract：OBJECTIVES:This meta-analysis was performed to determine the effects of various cholesterol-lowering treatments on the risk of stroke and its relationship with the extent of cholesterol lowering. BACKGROUND:Statins reduce the incidence of stroke, and it has been proposed that such effect is independent of cholesterol ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jacc.2009.07.062

    authors： De Caterina R,Scarano M,Marfisi R,Lucisano G,Palma F,Tatasciore A,Marchioli R

    更新日期：2010-01-19 00:00:00

  • Paired comparisons of efficacy of intravenous and oral procainamide in patients with inducible sustained ventricular tachyarrhythmias.

    abstract：:Thirty-eight patients who had inducible sustained ventricular tachycardia during baseline programmed electrical stimulation underwent electrophysiologic testing after both intravenous and oral administration of procainamide. Each had presented clinically with documented sustained ventricular tachycardia or out of hosp...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(91)90651-o

    authors： Interian A Jr,Zaman L,Velez-Robinson E,Kozlovskis P,Castellanos A,Myerburg RJ

    更新日期：1991-06-01 00:00:00

  • Enhanced external counterpulsation improves exercise tolerance, reduces exercise-induced myocardial ischemia and improves left ventricular diastolic filling in patients with coronary artery disease.

    abstract：OBJECTIVES:We examined whether enhanced external counterpulsation (EECP) improves myocardial ischemia, exercise tolerance and cardiac function in patients with coronary artery disease (CAD). BACKGROUND:Enhanced external counterpulsation reduces angina and improves exercise tolerance in patients with CAD. Some objectiv...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(00)01095-0

    authors： Urano H,Ikeda H,Ueno T,Matsumoto T,Murohara T,Imaizumi T

    更新日期：2001-01-01 00:00:00

  • Frequency and distribution of thin-cap fibroatheroma and ruptured plaques in human coronary arteries: a pathologic study.

    abstract：OBJECTIVES:Our purpose was to quantify the frequency and distribution of suspected vulnerable lesions, defined as thin-capped fibroatheroma (TCFA) and ruptured plaque, in human coronary artery autopsy specimens. BACKGROUND:Most acute coronary events and sudden death are believed to arise from rupture of a TCFA followe...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2007.04.086

    authors： Cheruvu PK,Finn AV,Gardner C,Caplan J,Goldstein J,Stone GW,Virmani R,Muller JE

    更新日期：2007-09-04 00:00:00

  • The case for surgery in obstructive hypertrophic cardiomyopathy.

    abstract：:Relief of left ventricular (LV) outflow obstruction in patients with hypertrophic cardiomyopathy (HCM) and disabling symptoms refractory to maximum medical management has historically been a surgical problem. Surgical septal myectomy permanently abolishes systolic anterior motion of the mitral valve and mitral regurgi...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2004.04.063

    authors： Maron BJ,Dearani JA,Ommen SR,Maron MS,Schaff HV,Gersh BJ,Nishimura RA

    更新日期：2004-11-16 00:00:00

  • Beta-blocker use and survival in patients with ventricular fibrillation or symptomatic ventricular tachycardia: the Antiarrhythmics Versus Implantable Defibrillators (AVID) trial.

    abstract：OBJECTIVES:To evaluate whether use of beta-adrenergic blocking agents, alone or in combination with specific antiarrhythmic therapy, is associated with improved survival in persons with ventricular fibrillation (VF) or symptomatic ventricular tachycardia (VT). BACKGROUND:The ability of beta-blockers to alter the morta...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0735-1097(99)00234-x

    authors： Exner DV,Reiffel JA,Epstein AE,Ledingham R,Reiter MJ,Yao Q,Duff HJ,Follmann D,Schron E,Greene HL,Carlson MD,Brodsky MA,Akiyama T,Baessler C,Anderson JL

    更新日期：1999-08-01 00:00:00

  • Staging Cardiac Damage in Patients With Asymptomatic Aortic Valve Stenosis.

    abstract：BACKGROUND:The optimal timing of intervention in patients with asymptomatic severe aortic stenosis (AS) remains controversial. OBJECTIVES:This multicenter study sought to test and validate the prognostic value of the staging of cardiac damage in patients with asymptomatic moderate to severe AS. METHODS:This study ret...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2019.04.065

    authors： Tastet L,Tribouilloy C,Maréchaux S,Vollema EM,Delgado V,Salaun E,Shen M,Capoulade R,Clavel MA,Arsenault M,Bédard É,Bernier M,Beaudoin J,Narula J,Lancellotti P,Bax JJ,Généreux P,Pibarot P

    更新日期：2019-07-30 00:00:00

  • Late increase in luminal diameter of aortocoronary venous bypass grafts associated with an increase in the vascular region under supply.

    abstract：:In a previous study, a significant inverse relation was found between the luminal size of aortocoronary venous bypass grafts and the vascular resistance of the coronary region that was perfused by the bypass graft in late stages after bypass surgery. This observation suggested that changes in the graft-dependent vascu...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(87)80153-5

    authors： Herrmann G,Simon R,Amende I,Frank G,Borst HG,Lichtlen PR

    更新日期：1987-07-01 00:00:00

  • Gaps in referral to cardiac rehabilitation of patients undergoing percutaneous coronary intervention in the United States.

    abstract：BACKGROUND:Rates of referral to cardiac rehabilitation after percutaneous coronary intervention (PCI) have been historically low despite the evidence that rehabilitation is associated with lower mortality in PCI patients. OBJECTIVES:This study sought to determine the prevalence of and factors associated with referral ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2015.02.063

    authors： Aragam KG,Dai D,Neely ML,Bhatt DL,Roe MT,Rumsfeld JS,Gurm HS

    更新日期：2015-05-19 00:00:00