Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls.

abstract：BACKGROUND:Impaired spatial working memory (SWM) is a robust feature of schizophrenia and has been linked to the risk of developing psychosis in people with an at-risk mental state (ARMS). We used functional magnetic resonance imaging (fMRI) to examine the neural substrate of SWM in the ARMS and in patients who had jus...

journal_title：Psychological medicine

authors： Broome MR,Fusar-Poli P,Matthiasson P,Woolley JB,Valmaggia L,Johns LC,Tabraham P,Bramon E,Williams SC,Brammer MJ,Chitnis X,Zelaya F,McGuire PK

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:In other branches of epidemiology, stratum specific likelihood ratios (SSLRs) have been found to be preferable to fixed best threshold approaches to screening instruments. This paper presents SSLRs of GHQ-12 and GHQ-28 and compares the SSLR method with the traditional optimal threshold approach. METHODS:Ran...

journal_title：Psychological medicine

authors： Furukawa TA,Goldberg DP,Rabe-Hesketh S,Ustün TB

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:Three prior population-based twin studies, none of which was nationally representative, suggested that both genetic and familial-environmental factors contribute to family resemblance for lifetime cannabis use. We seek to replicate these results in a US national probability sample of twin and sibling pairs e...

journal_title：Psychological medicine

authors： Kendler KS,Neale MC,Thornton LM,Aggen SH,Gilman SE,Kessler RC

更新日期：2002-04-01 00:00:00

abstract：:It has been proposed that a high level of agreement between informants' reports about events and happenings ('objective' data) is a sound basis for establishing (a) the validity of the measure which is based on the reports, and (b) the nature of objective reality. In this paper it is argued that such agreement may not...

journal_title：Psychological medicine

authors： Platt S

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND:Assaultive violence events are associated with increased risk for adverse psychiatric outcomes, including post-traumatic stress (PTS), depression, and generalized anxiety. Prior research has indicated that economic, legal, and social stressors that could follow assaultive events may explain the increased ris...

journal_title：Psychological medicine

authors： Lowe SR,Joshi S,Galea S,Aiello AE,Uddin M,Koenen KC,Cerdá M

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:White matter (WM) impairments have been reported in patients with bipolar disorder (BD) and those at high familial risk of developing BD. However, the distribution of these impairments has not been well characterized. Few studies have examined WM integrity in young people early in the course of illness and i...

journal_title：Psychological medicine

authors： Roberts G,Wen W,Frankland A,Perich T,Holmes-Preston E,Levy F,Lenroot RK,Hadzi-Pavlovic D,Nurnberger JI,Breakspear M,Mitchell PB

更新日期：2016-08-01 00:00:00

abstract：:There have been numerous exhortations for more 'translational research'. A selective review of historical examples of research leading to health benefits is used to consider the various forms of successful interplay between basic science and clinical applications. This is followed by a consideration of key neuroscienc...

journal_title：Psychological medicine

authors： Rutter M,Plomin R

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:The objective was to describe patients presenting themselves at emergency-care settings following a suicide attempt in eight culturally different sites [Campinas (Brazil), Chennai (India), Colombo (Sri Lanka), Durban (South Africa), Hanoi (Viet Nam), Karaj (Iran), Tallinn (Estonia), and Yuncheng, (China)]. ...

journal_title：Psychological medicine

authors： Fleischmann A,Bertolote JM,De Leo D,Botega N,Phillips M,Sisask M,Vijayakumar L,Malakouti K,Schlebusch L,De Silva D,Nguyen VT,Wasserman D

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Depressive syndromes not fulfilling the criteria for specified disorders (subthreshold depression, SD) may be clinically important. We aimed to study SD in old and very old age, in comparison with subjects with no depressive symptoms (NDS) and subjects with major depression (MD). METHODS:A community-based r...

journal_title：Psychological medicine

authors： Geiselmann B,Linden M,Helmchen H

更新日期：2001-01-01 00:00:00

abstract：:Using the 40-item Eating Attitudes Test and other self-report questions, a two-stage screening survey of 1020 (F 646, M 374) Chinese bilingual university students in Hong Kong showed that although female students were 'underweight' by Western standard, the majority of them and nearly all female students above a body m...

journal_title：Psychological medicine

authors： Lee S

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Cognitive models of obsessive-compulsive disorder (OCD) posit dysfunctional appraisal of disorder-relevant stimuli in patients, suggesting disturbances in the processes relying on amygdala-prefrontal connectivity. Recent neuroanatomical models add to the traditional view of dysfunction in corticostriatal cir...

journal_title：Psychological medicine

authors： Paul S,Beucke JC,Kaufmann C,Mersov A,Heinzel S,Kathmann N,Simon D

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:There is uncertainty about the incidence of breakthrough psychosis in treatment adherent patients, and the role that factors, such as cumulative antipsychotic exposure, play in this phenomenon. METHODS:In a nationwide cohort of individuals treated for schizophrenia-spectrum disorders in Finland between 1 Ja...

journal_title：Psychological medicine

authors： Rubio JM,Taipale H,Correll CU,Tanskanen A,Kane JM,Tiihonen J

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Retrospective studies have consistently indicated an association between maladaptive parenting and borderline personality disorder (BPD). This requires corroboration with prospective, longitudinal designs. We investigated the association between suboptimal parenting and parent conflict in childhood and BPD s...

journal_title：Psychological medicine

authors： Winsper C,Zanarini M,Wolke D

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:With regard to current neurobiological theories, the aim of our study was to examine possible alterations of temporal and frontal lobe volume in panic disorder (PD). METHOD:Seventeen in-patients with PD and a group of healthy control subjects (HC) matched for age and gender were investigated by quantitative...

journal_title：Psychological medicine

authors： Sobanski T,Wagner G,Peikert G,Gruhn U,Schluttig K,Sauer H,Schlösser R

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Electroconvulsive therapy (ECT) is widely applied to treat severe depression resistant to standard treatment. Results from previous studies comparing the cost-effectiveness of this technique with treatment alternatives such as repetitive transcranial magnetic stimulation (rTMS) are conflicting. METHOD:We co...

journal_title：Psychological medicine

authors： Vallejo-Torres L,Castilla I,González N,Hunter R,Serrano-Pérez P,Perestelo-Pérez L

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:The mental and physical health of individuals with a psychotic illness are typically poor. Access to psychosocial interventions is important but currently limited. Telephone-delivered interventions may assist. In the current systematic review, we aim to summarise and critically analyse evidence for telephone...

journal_title：Psychological medicine

authors： Baker AL,Turner A,Beck A,Berry K,Haddock G,Kelly PJ,Bucci S

更新日期：2018-12-01 00:00:00

abstract：:Referral rates to psychiatric services in North-East Scotland by 147 individual urban and rural general practitioners were calculated. Among city doctors, the greater the number of years since qualification the more patients were referred. Single-handed city doctors also had very high referral rates. Subsequent interv...

journal_title：Psychological medicine

authors： Robertson NC

更新日期：1979-05-01 00:00:00

abstract：:Long-stay patients who were discharged from Friern and Claybury hospitals during the 6-year period between September 1985 and August 1991 were followed up for at least 1 year and the details of all readmissions were recorded. Of the 615 hospital leavers, some 178 (29%) were readmitted at some time during the follow-up...

journal_title：Psychological medicine

authors： Gooch C,Leff J

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:Rumination is an important cognitive risk factor for onset and relapse of depression. However, no studies have employed a dimensional approach in investigating the neural correlates of rumination and the relationship with depression. METHOD:Non-clinical healthy subjects (n = 306), who completed the classica...

journal_title：Psychological medicine

authors： Wang K,Wei D,Yang J,Xie P,Hao X,Qiu J

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Psychological literature and clinical lore suggest that there may be systematic differences in how various demographic groups experience depressive symptoms, particularly somatic symptoms. The aim of the current study was to use methods based on item response theory (IRT) to examine whether, when equating fo...

journal_title：Psychological medicine

authors： Uebelacker LA,Strong D,Weinstock LM,Miller IW

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Prior research on work-related factors in the aetiology of psychiatric disorders has been concentrated on job control, job demands and social support. To broaden the view to managerial procedures, we examined whether the extent to which employees are treated with equity in the workplace predicts their mental...

journal_title：Psychological medicine

authors： Kivimäki M,Elovainio M,Vahtera J,Virtanen M,Stansfeld SA

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Research on the subject of insight has been hampered by difficulties in definition and reliable measurement. METHODS:We compared several rating scales to measure insight on a group of 33 psychotic patients as well as assessing patients' psychopathology, clinical characteristics and cognitive functioning. R...

journal_title：Psychological medicine

authors： Sanz M,Constable G,Lopez-Ibor I,Kemp R,David AS

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Previous studies have highlighted the role of the brain reward and cognitive control systems in the etiology of anorexia nervosa (AN). In an attempt to disentangle the relative contribution of these systems to the disorder, we used functional magnetic resonance imaging (fMRI) to investigate hemodynamic respo...

journal_title：Psychological medicine

authors： Boehm I,King JA,Bernardoni F,Geisler D,Seidel M,Ritschel F,Goschke T,Haynes JD,Roessner V,Ehrlich S

更新日期：2018-04-01 00:00:00

abstract：:In an earlier paper we found that a model of depression developed on a sample of women in a London population was confirmed in a female population in the Outer Hebrides. Differences in the rates of onset and chronic cases between the two populations, however, suggested that the Scottish women might be more likely to b...

journal_title：Psychological medicine

authors： Prudo R,Brown GW,Harris T,Dowland J

更新日期：1981-08-01 00:00:00

abstract：BACKGROUND:A few previous studies suggest that a large number of individuals do not present at hospital following a suicide attempt, complicating recurrence prevention and prevalence estimation. METHODS:Data were extracted from a regular phone survey in representative samples of the French population aged 18-75 years ...

journal_title：Psychological medicine

authors： Jollant F,Hawton K,Vaiva G,Chan-Chee C,du Roscoat E,Leon C

更新日期：2020-07-03 00:00:00

abstract：BACKGROUND:There is evidence that cannabis use might be relevant to the aetiology of schizophrenia. We aimed to measure any change in cannabis use over time in those first presenting with schizophrenia in South-East London from 1965 to 1999, and compare this with change in use in those presenting with non-psychotic psy...

journal_title：Psychological medicine

authors： Boydell J,van Os J,Caspi A,Kennedy N,Giouroukou E,Fearon P,Farrell M,Murray RM

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Chronic fatigue is a common symptom of multiple sclerosis (MS). A randomized controlled trial (RCT) showed that cognitive behavioural therapy (CBT) was more effective in reducing MS fatigue than relaxation training (RT). The aim of the current study was to analyse additional data from this trial to determine...

journal_title：Psychological medicine

authors： Knoop H,van Kessel K,Moss-Morris R

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Pharmaceutical industry funding of psychiatric research has increased significantly in recent decades, raising the question of a relationship between pharmaceutical company funding of clinical psychiatric studies and the outcomes of those studies. This study examines this relationship. METHOD:Abstracts of a...

journal_title：Psychological medicine

authors： Kelly RE Jr,Cohen LJ,Semple RJ,Bialer P,Lau A,Bodenheimer A,Neustadter E,Barenboim A,Galynker II

更新日期：2006-11-01 00:00:00

abstract：:Data are presented from a study of acculturation and psychiatric disorder in 291 Greek Cypriot immigrants from the general population of Camberwell, south London. We hypothesized that 'pre-acculturation' would protect against mental disorder, that difficulties in the period immediately after migration would increase t...

journal_title：Psychological medicine

authors： Mavreas V,Bebbington P

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Although many case-control studies have replicated an association between dysfunctional parenting and a lifetime diagnosis of depression, few epidemiological studies have explored the association. In addition, little is known about the association in non-western countries. METHODS:Using logistic regression ...

journal_title：Psychological medicine

authors： Sato T,Sakado K,Uehara T,Narita T,Hirano S,Nishioka K,Kasahara Y

更新日期：1998-05-01 00:00:00