Intratumoral Heterogeneity of Glioblastoma Infiltration Revealed by Joint Histogram Analysis of Diffusion Tensor Imaging.

Abstract:

BACKGROUND:Glioblastoma is a heterogeneous disease characterized by its infiltrative growth, rendering complete resection impossible. Diffusion tensor imaging (DTI) shows potential in detecting tumor infiltration by reflecting microstructure disruption. OBJECTIVE:To explore the heterogeneity of glioblastoma infiltration using joint histogram analysis of DTI, to investigate the incremental prognostic value of infiltrative patterns over clinical factors, and to identify specific subregions for targeted therapy. METHODS:A total of 115 primary glioblastoma patients were prospectively recruited for surgery and preoperative magnetic resonance imaging. The joint histograms of decomposed anisotropic and isotropic components of DTI were constructed in both contrast-enhancing and nonenhancing tumor regions. Patient survival was analyzed with joint histogram features and relevant clinical factors. The incremental prognostic values of histogram features were assessed using receiver operating characteristic curve analysis. The correlation between the proportion of diffusion patterns and tumor progression rate was tested using Pearson correlation. RESULTS:We found that joint histogram features were associated with patient survival and improved survival model performance. Specifically, the proportion of nonenhancing tumor subregion with decreased isotropic diffusion and increased anisotropic diffusion was correlated with tumor progression rate (P = .010, r = 0.35), affected progression-free survival (hazard ratio = 1.08, P < .001), and overall survival (hazard ratio = 1.36, P < .001) in multivariate models. CONCLUSION:Joint histogram features of DTI showed incremental prognostic values over clinical factors for glioblastoma patients. The nonenhancing tumor subregion with decreased isotropic diffusion and increased anisotropic diffusion may indicate a more infiltrative habitat and potential treatment target.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Li C,Wang S,Yan JL,Piper RJ,Liu H,Torheim T,Kim H,Zou J,Boonzaier NR,Sinha R,Matys T,Markowetz F,Price SJ

doi

10.1093/neuros/nyy388

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

524-534

issue

4

eissn

0148-396X

issn

1524-4040

pii

5099458

journal_volume

85

pub_type

杂志文章
  • Reflections on nuclear warfare.

    abstract::The author looks back on his more than 70 years of familiarity with Americans involved in warfare, noting their loyal support for our country's objectives. Drawing on the Einstein equation, his own visits to Hiroshima and Nagasaki, and current literature, he, as a physician, belatedly concurs with those who look on th...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198304000-00001

    authors: Evans JP

    更新日期:1983-04-01 00:00:00

  • Expression of integrins in cerebral arteriovenous and cavernous malformations.

    abstract:OBJECTIVE:To assess and compare levels and patterns of expression for integrins alphavbeta1, alphavbeta3, and alphavbeta5 in arteriovenous malformations (AVMs) and cavernous malformations (CCMs) of the brain. MATERIALS AND METHODS:Specimens from 10 AVM and 10 CCM lesions were selected from 112 patients with AVMs and 9...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000192174.55131.09

    authors: Seker A,Yildirim O,Kurtkaya O,Sav A,Günel M,Pamir MN,Kiliç T

    更新日期:2006-01-01 00:00:00

  • Measurement of local directional pressures in the brain with mass.

    abstract::In order to understand the effects and the direction of pressure transmitted from a mass lesion through various brain structures, miniature strain gauges were inserted in different brain locations in eight anesthetized monkeys. Mass lesions were created by inflating a balloon in either of two locations--subcortical in...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199210000-00017

    authors: Kuchiwaki H,Misu N,Takada S,Ishiguri H,Inao S,Sugita K

    更新日期:1992-10-01 00:00:00

  • Modifications of the transoral approach to the craniovertebral junction: anatomic study and clinical correlations.

    abstract:OBJECTIVE:This study was designed to more precisely characterize the changes in exposure achieved by modifying the standard transoral approach by sequential mandibulotomy and mandibuloglossotomy with or without palatotomy. METHODS:A series of cadaveric dissections was performed and the operative distance and angle of ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000317386.99055.3f

    authors: Youssef AS,Guiot B,Black K,Sloan AE

    更新日期:2008-03-01 00:00:00

  • High-resolution three-dimensional magnetic resonance angiography and three-dimensional spoiled gradient-recalled imaging in the evaluation of neurovascular compression in patients with trigeminal neuralgia: a double-blind pilot study.

    abstract:OBJECTIVE:To assess the value of high-resolution three-dimensional (3D) time-of-flight (TOF) magnetic resonance (MR) angiography and gadolinium (Gad)-enhanced 3D spoiled gradient-recalled imaging in the visualization of neurovascular compression in patients with trigeminal neuralgia. METHODS:Forty-eight patients with ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000197117.34888.DE

    authors: Anderson VC,Berryhill PC,Sandquist MA,Ciaverella DP,Nesbit GM,Burchiel KJ

    更新日期:2006-04-01 00:00:00

  • Neurinoma of the trigeminal root and atypical trigeminal neuralgia: their commonality.

    abstract::Two cases of very small trigeminal neurinomas arising proximal to Meckel's cave are presented. We believe that the overlap of the symptoms and signs of these tumors with those of atypical trigeminal neuralgia strengthens the concept of the latter entity also being due to compression of the trigeminal nerve solely with...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Yonas H,Jannetta PJ

    更新日期:1980-03-01 00:00:00

  • Significant differences in the postoperative morphological and hemodynamic conditions of carotid arteries of patients undergoing stenting or endarterectomy with patch angioplasty.

    abstract:OBJECTIVE:Carotid endarterectomy with a patch graft (Patch CEA) has been our standard treatment for patients with carotid artery stenosis, but carotid artery stenting (CAS) has emerged as an alternative. The purpose of this study was to compare the postoperative changes in the configurations and the flow velocities of ...

    journal_title:Neurosurgery

    pub_type: 临床试验,杂志文章

    doi:10.1227/01.NEU.0000358952.12917.DF

    authors: Tokunaga K,Sugiu K,Hayase H,Nishida A,Date I

    更新日期:2009-11-01 00:00:00

  • Closure of myelorachischisis defects with reverse latissimus dorsi myocutaneous flaps.

    abstract::The closure of myelorachischisis defects has been difficult and at times complicated. Over the past 2 decades, the use of rotational advancement flaps has been increasingly popular, but can be attended by instances of skin ischemia and necrosis. The development of the myocutaneous and muscle flap concept has aided rec...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198209000-00015

    authors: Clark DH,Walsh JW,Luce EA

    更新日期:1982-09-01 00:00:00

  • Intraoperative brain shift and deformation: a quantitative analysis of cortical displacement in 28 cases.

    abstract:OBJECTIVE:A quantitative analysis of intraoperative cortical shift and deformation was performed to gain a better understanding of the nature and extent of this problem and the resultant loss of spatial accuracy in surgical procedures coregistered to preoperative imaging studies. METHODS:Three-dimensional feature trac...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199810000-00010

    authors: Roberts DW,Hartov A,Kennedy FE,Miga MI,Paulsen KD

    更新日期:1998-10-01 00:00:00

  • Iatrogenic vertebrobasilar insufficiency after surgery of the subclavian or brachial artery: review of three cases.

    abstract:OBJECTIVE AND IMPORTANCE:Vertebrobasilar insufficiency resulting from disease of the subclavian artery is well recognized. Usually, this occurs as the "subclavian steal" syndrome in the context of chronic subclavian stenosis and is consequently well tolerated because of collateralization. Acute disruption of the hemody...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Amar AP,Levy ML,Giannotta SL

    更新日期:1998-12-01 00:00:00

  • Preoperative imaging to predict intraoperative changes in tumor-to-corticospinal tract distance: an analysis of 45 cases using high-field intraoperative magnetic resonance imaging.

    abstract:BACKGROUND:Preoperative diffusion tensor imaging (DTI) is used to demonstrate corticospinal tract (CST) position. Intraoperative brain shifts may limit preoperative DTI value, and studies characterizing such shifts are lacking. OBJECTIVE:To examine tumor characteristics that could predict intraoperative shift in tumor...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000000338

    authors: Shahar T,Rozovski U,Marko NF,Tummala S,Ziu M,Weinberg JS,Rao G,Kumar VA,Sawaya R,Prabhu SS

    更新日期:2014-07-01 00:00:00

  • Transient hyperemia immediately after rapid decompression of chronic subdural hematoma.

    abstract:OBJECTIVE:Intracerebral hemorrhage occurring after removal of a chronic subdural hematoma (CSH) is a rare but usually devastating postoperative complication. In patients with CSH, we determined cerebral blood flow immediately after surgical decompression to clarify the pathogenic mechanism of this complication. METHOD...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199909000-00014

    authors: Ogasawara K,Koshu K,Yoshimoto T,Ogawa A

    更新日期:1999-09-01 00:00:00

  • Idiopathic brachial neuritis.

    abstract::Parsonage-Turner syndrome (PTS) is a rare syndrome of unknown cause, affecting mainly the lower motor neurons of the brachial plexus. The brachial plexus is a group of nerves that conduct signals from the spine to the shoulder, arm, and hand. PTS is usually characterized by the sudden onset of severe 1-sided shoulder ...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/01.NEU.0000345355.59438.D1

    authors: Sumner AJ

    更新日期:2009-10-01 00:00:00

  • Lateral cervical spine dislocation and vertebral artery injury.

    abstract::Although anterior and posterior traumatic displacement of cervical vertebrae are commonly noted, and the devastating neurological deficits associated with these injuries have been amply defined, lateral displacement with fractures has been rarely recognized, and the clinical significance of this injury has been overlo...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/00006123-199209000-00012

    authors: Parent AD,Harkey HL,Touchstone DA,Smith EE,Smith RR

    更新日期:1992-09-01 00:00:00

  • Reevaluation of syringosubarachnoid shunt for syringomyelia with Chiari malformation.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the effectiveness of syringosubarachnoid (S-S) shunting for syringomyelia with Chiari malformation. The authors describe the technical methods of performing the S-S shunt and the clinical results, including shunt malfunction. METHODS:Forty-nine patients underwent S-S...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200002000-00026

    authors: Iwasaki Y,Hida K,Koyanagi I,Abe H

    更新日期:2000-02-01 00:00:00

  • Primary Leptomeningeal Gliomatosis in Children and Adults: A Morphological and Molecular Comparative Study With Literature Review.

    abstract:BACKGROUND:Primary leptomeningeal gliomatosis (PLG) is a poorly recognized tumor of the central nervous system. OBJECTIVE:To describe the histopathological, immunohistochemical, and molecular features of PLG. METHODS:Results of our multicentric retrospective study of 6 PLG cases (3 pediatric and 3 adult) were compare...

    journal_title:Neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.1227/NEU.0000000000001028

    authors: Tauziede-Espariat A,Maues de Paula A,Pages M,Laquerriere A,Caietta E,Delpont B,Viennet G,Medeiros de Bustos E,Moulin T,Barnerias C,Vauleon E,Grill J,Chiforeanu D,Vasiljevic A,Varlet P

    更新日期:2016-03-01 00:00:00

  • Surgical treatment of spinal extradural arteriovenous fistula with parenchymal drainage: report on 5 cases.

    abstract:BACKGROUND AND IMPORTANCE:Spinal extradural arteriovenous fistula (SEDAVF) with parenchymal drainage (type A) is a rare clinical entity that causes venous congestive myelopathy. Treatment includes endovascular and open microsurgical interventions. We reviewed the clinical records of patients treated for a type A SEDAVF...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000000189

    authors: Niizuma K,Endo T,Sato K,Takada S,Sugawara T,Mikawa S,Tominaga T

    更新日期:2013-12-01 00:00:00

  • In vitro study of biomechanical behavior of anterior and transforaminal lumbar interbody instrumentation techniques.

    abstract:OBJECTIVE:To study the biomechanical behavior of lumbar interbody instrumentation techniques using titanium cages as either transforaminal lumbar interbody fusion (TLIF) or anterior lumbar interbody fusion (ALIF), with and without posterior pedicle fixation. METHODS:Six fresh-frozen lumbar spines (L1-L5) were loaded w...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000245609.01732.E4

    authors: Niemeyer TK,Koriller M,Claes L,Kettler A,Werner K,Wilke HJ

    更新日期:2006-12-01 00:00:00

  • Stereotactic radiosurgery for tentorial dural arteriovenous fistulae draining into the vein of Galen: report of two cases.

    abstract:OBJECTIVE AND IMPORTANCE:Treatment of tentorial dural arteriovenous fistulae (DAVFs) primarily draining into the vein of Galen remains a therapeutic challenge. We present two cases of ruptured galenic DAVFs that were successfully treated with gamma knife radiosurgery. CLINICAL PRESENTATION:Patient 1, a 66-year-old wom...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200003000-00039

    authors: Shin M,Kurita H,Tago M,Kirino T

    更新日期:2000-03-01 00:00:00

  • Syndrome of inappropriate antidiuretic hormone secretion after spontaneous subarachnoid hemorrhage: a reversible cause of clinical deterioration.

    abstract::The syndrome of inappropriate antidiuretic hormone secretion (SIADH) developed approximately 7 days after a spontaneous subarachnoid hemorrhage in a 63-year-old woman with an anterior cerebral artery aneurysm. The hyponatremia associated with this syndrome resulted in a deterioration of the patient's clinical conditio...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-197811000-00016

    authors: Wise BL

    更新日期:1978-11-01 00:00:00

  • Utility of preoperative magnetic resonance imaging myelography for identifying dural defects in patients with spinal extradural arachnoid cysts: case report.

    abstract:OBJECTIVE:Preoperative magnetic resonance imaging (MRI) myelography scans demonstrated a dural defect in a 50-year-old man with an epidural arachnoid cyst who had a 29-year history of untreated weakness and numbness both lower limbs. METHODS:MRI scans showed a dorsal intraspinal extradural cystic lesion at the level f...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000232659.56174.28

    authors: Miyamoto M,Kim K,Matsumoto R,Isobe M,Isu T

    更新日期:2006-10-01 00:00:00

  • Radiation therapy in the treatment of cerebral astrocytoma.

    abstract::With the advent of more sensitive diagnostic techniques, we are encountering an increasing number of young patients harboring cerebral astrocytoma. The great danger in such patients is that the astrocytoma cells will undergo dedifferentiation to a higher state of malignancy. An essential question is whether the use of...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198706000-00028

    authors: Morantz RA

    更新日期:1987-06-01 00:00:00

  • Patients with moderate head injury: a prospective multicenter study of 315 patients.

    abstract:OBJECTIVE:To analyze the risk factors of worst outcome associated with moderate head injury. METHODS:Data on patients with moderate head injury were collected prospectively in 11 Italian neurosurgical units over a period of 18 months. Patients older than 18 years with blunt head injury and at least one Glasgow Coma Sc...

    journal_title:Neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.1227/01.NEU.0000340796.18738.F7

    authors: Compagnone C,d'Avella D,Servadei F,Angileri FF,Brambilla G,Conti C,Cristofori L,Delfini R,Denaro L,Ducati A,Gaini SM,Stefini R,Tomei G,Tagliaferri F,Trincia G,Tomasello F

    更新日期:2009-04-01 00:00:00

  • Hemorrhagic infarction after vasospasm due to ruptured cerebral aneurysm.

    abstract::Hemorrhagic infarction after vasospasm is a rare condition in patients with aneurysmal subarachnoid hemorrhage (SAH). Induced hypertensive therapy is used for patients with vasospasm, but this treatment has a risk of inducing hemorrhagic infarction. A total of 221 patients whose first computed tomographic (CT) scans w...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198604000-00004

    authors: Terada T,Komai N,Hayashi S,Moriwaki H,Hyoutani G,Uematsu Y,Karasawa J,Kikuchi H

    更新日期:1986-04-01 00:00:00

  • Natural history of arteriovenous malformations of the brain: a clinical study.

    abstract::The natural history of intracranial arteriovenous malformations (AVMs) was studied in 131 patients. The 83 patients managed nonsurgically and the 48 patients treated surgically were followed for an average of 8 years. Hemorrhage occurred in 61.8% of all patients. A second hemorrhage occurred in 67.4% of the survivors ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198411000-00003

    authors: Fults D,Kelly DL Jr

    更新日期:1984-11-01 00:00:00

  • Adjuvant gamma knife stereotactic radiosurgery at the time of tumor progression potentially improves survival for patients with glioblastoma multiforme.

    abstract:OBJECTIVE:Gamma knife stereotactic radiosurgery (GK-SRS) is a safe and noninvasive treatment used as adjuvant therapy for patients with glioblastoma multiforme (GBM). Several studies have yielded conflicting results in the effectiveness of radiosurgery in GBM. This study is a retrospective review of our institutional e...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Hsieh PC,Chandler JP,Bhangoo S,Panagiotopoulos K,Kalapurakal JA,Marymont MH,Cozzens JW,Levy RM,Salehi S

    更新日期:2005-10-01 00:00:00

  • Changes in the immunophenotype of recurrent pituitary adenomas.

    abstract::Only two cases have been reported of a pituitary adenoma that changed phenotype between its initial resection and recurrence. To determine the frequency of such cases among our patients, we examined the clinical course of these tumors and characterized any patterns. We reviewed the charts of 1023 patients with pituita...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199407000-00006

    authors: Mindermann T,Kovacs K,Wilson CB

    更新日期:1994-07-01 00:00:00

  • Delayed retraction of the pipeline embolization device and corking failure: pitfalls of pipeline embolization device placement in the setting of a ruptured aneurysm.

    abstract:BACKGROUND AND IMPORTANCE:The safety of flow-diverting stents for the treatment of ruptured intracranial aneurysms is unknown. CLINICAL PRESENTATION:A 35-year-old woman with a ruptured dissecting aneurysm of the intradural right vertebral artery and incorporating the right posterior inferior cerebellar artery was trea...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e31827fc9be

    authors: McTaggart RA,Santarelli JG,Marcellus ML,Steinberg GK,Dodd RL,Do HM,Marks MP

    更新日期:2013-06-01 00:00:00

  • Suppression of splenic natural killer cell activity in rats with brain tumors.

    abstract::After inoculating 9L glioma cells into the brains or into subcutaneous regions of the back of rats, we investigated splenic natural killer (NK) cell activity for 3 weeks using a 4-hour 51Cr release assay. Only rats with brain tumors showed decreased splenic NK cell activity. The spleens of these rats were morphologica...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198807000-00005

    authors: Imaya H,Matsuura H,Kudo M,Nakazawa S

    更新日期:1988-07-01 00:00:00

  • Clinical and Short-Term Radiographic Outcomes of Minimally Invasive Transforaminal Lumbar Interbody Fusion With Expandable Lordotic Devices.

    abstract:BACKGROUND:Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is a well-accepted procedure for the treatment of degenerative lumbar disease. However, its ability to restore lumbar lordosis has been limited. Development of expandable lordotic interbody devices has challenged this limitation, furthering...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1093/neuros/nyz402

    authors: McMordie JH,Schmidt KP,Gard AP,Gillis CC

    更新日期:2020-02-01 00:00:00