Suppression of splenic natural killer cell activity in rats with brain tumors.

Abstract:

:After inoculating 9L glioma cells into the brains or into subcutaneous regions of the back of rats, we investigated splenic natural killer (NK) cell activity for 3 weeks using a 4-hour 51Cr release assay. Only rats with brain tumors showed decreased splenic NK cell activity. The spleens of these rats were morphologically small and atrophic. Expansive brain tumors were compressing the basal ganglia, thalamus, and hypothalamus after 2 weeks, and the rats ultimately died of cerebral herniation, usually by 3 weeks after inoculation. The decreased splenic NK cell activity in rats with brain tumors might be the result of neuroimmunomodulation secondary to hypothalamic dysfunction due to increasing tumor compression.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Imaya H,Matsuura H,Kudo M,Nakazawa S

doi

10.1227/00006123-198807000-00005

subject

Has Abstract

pub_date

1988-07-01 00:00:00

pages

23-6

issue

1

eissn

0148-396X

issn

1524-4040

journal_volume

23

pub_type

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