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Combined application of Indocyanine green (ICG) and laser lead to targeted tumor cell destruction.

Abstract：

PURPOSE:Precise excision of neuroblastoma is challenging, especially when tumors adhere to vital structures. Indocyanine green (ICG), an FDA-approved dye with absorption peaking at 800 nm, can absorb the near IR laser energy and release heat in the dyed tissue. We hypothesize that by injecting ICG at tumor sites followed by precise laser application, tumor cell death can be selectively targeted. METHODS:Orthotopic neuroblastoma tumors were created in the adrenal gland of immunocompromised mice. Tumor, liver, kidney, and muscle tissues were chosen for ICG injection. Intervention variables included presence of tumor capsule, continuous vs. pulsed laser treatment and total energy delivered. Control groups included laser or ICG only. Tissues were stained with hematoxylin/eosin. RESULTS:Continuous wave laser generated excessive heat, causing damage in all tissues. When using pulsed laser treatment, liver, kidney, muscle, and intact tumor tissues showed no cell death when treated with laser alone or laser plus ICG. Tumor tissue with the capsule removed, however, showed cell death on histology. CONCLUSIONS:Pulsed laser treatment combined with ICG causes targeted tumor cell death in neuroblastoma tumor without capsule. No cell death was observed when tumor capsule was present, when only laser was used, or when applied over non-tumor tissues.

journal_name

J Pediatr Surg

journal_title

Journal of pediatric surgery

authors

Taylor JS,Zeki J,Ikegaki N,Chen LL,Chiu B

doi

10.1016/j.jpedsurg.2018.08.013

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

2475-2479

issue

12

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(18)30519-0

journal_volume

53

pub_type

杂志文章

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