Abstract：
:Physiologically relevant ALK (anaplastic lymphoma kinase) expression was not detected in human and mouse monocytes and macrophages, suggesting that the effects of bioactive compounds on stimulator of interferon genes (STING) activation may not depend on ALK.
journal_name
Sci Transl Medjournal_title
Science translational medicineauthors
Blasco RB,Patrucco E,Mota I,Tai WT,Chiarle Rdoi
10.1126/scitranslmed.aar4321subject
Has Abstractpub_date
2018-12-12 00:00:00issue
471eissn
1946-6234issn
1946-6242pii
10/471/eaar4321journal_volume
10pub_type
评论,杂志文章abstract：:High doses of oral vitamin D3 attenuate skin inflammation following experimentally induced sun damage. ...
journal_title：Science translational medicine
pub_type： 评论,杂志文章
doi：10.1126/scitranslmed.aan5233
更新日期：2017-06-14 00:00:00
abstract：:Anti-CTLA-4 treatment improves the survival of patients with advanced-stage melanoma. However, although the anti-CTLA-4 antibody ipilimumab is now an approved treatment for patients with metastatic disease, it remains unknown by which mechanism it boosts tumor-specific T cell activity. In particular, it is unclear whe...
journal_title：Science translational medicine
pub_type： 杂志文章
doi：10.1126/scitranslmed.3008918
更新日期：2014-09-17 00:00:00
abstract：:Biomedical engineering tools can be harnessed to address some of the world's most challenging nondisease-focused problems. ...
journal_title：Science translational medicine
pub_type： 杂志文章
doi：10.1126/scitranslmed.3009067
更新日期：2014-12-10 00:00:00
abstract：:Overcoming drug resistance and targeting leukemic stem cells (LSCs) remain major challenges in curing BCR-ABL+ human leukemia. Using an advanced drug/proliferation screen, we have uncovered a prosurvival role for protein phosphatase 2A (PP2A) in tyrosine kinase inhibitor (TKI)-insensitive leukemic cells, regulated by ...
journal_title：Science translational medicine
pub_type： 杂志文章
doi：10.1126/scitranslmed.aan8735
更新日期：2018-02-07 00:00:00
abstract：:Public health emergencies, such as an Ebola disease outbreak, provide a complex and challenging environment for the evaluation of candidate vaccines. Here, we outline the need for flexible and responsive vaccine trial designs to be used in public health emergencies, and we summarize recommendations for their use in th...
journal_title：Science translational medicine
pub_type： 杂志文章,评审
doi：10.1126/scitranslmed.aat0360
更新日期：2019-07-03 00:00:00
abstract：:Functional magnetic resonance imaging offers an unprecedented opportunity to evaluate and compare drug effects on human brain activity and to provide systems-level predictions for how new drugs for chronic pain will affect the brain, thus accelerating drug discovery and repurposing (Duff et al., this issue). ...
journal_title：Science translational medicine
pub_type： 评论,杂志文章
doi：10.1126/scitranslmed.3010342
更新日期：2015-02-11 00:00:00
abstract：:Prolonged life expectancy in the 20th century has been one of humankind's greatest triumphs. However, the substantial increase in the human life span has ushered in a new concern: healthy aging. Because infectious diseases prominently contribute to morbidity in the particularly vulnerable elderly population, strategie...
journal_title：Science translational medicine
pub_type： 杂志文章,评审
doi：10.1126/scitranslmed.3005624
更新日期：2013-05-15 00:00:00
abstract：:Cooperative oncogenic effects resulting from the loss of PTEN and overexpression of MYC overcome the deleterious effects of endoplasmic reticulum stress not only to promote the growth of aggressive prostate cancer but also to expose a new therapy target for this disease (Nguyen et al, this issue). ...
journal_title：Science translational medicine
pub_type： 杂志文章,评审
doi：10.1126/scitranslmed.aat3975
更新日期：2018-05-02 00:00:00
abstract：:We outline the fundamental properties of a highly participatory rapid learning system that can be developed in part from meaningful use of electronic health records (EHRs). Future widespread adoption of EHRs will make increasing amounts of medical information available in computable form. Secured and trusted use of th...
journal_title：Science translational medicine
pub_type： 杂志文章
doi：10.1126/scitranslmed.3001456
更新日期：2010-11-10 00:00:00
abstract：:Preclinical data suggest the possibility of repurposing a drug for early intervention in envenoming by snake venom rich in metalloproteinases (Albulescu et al., this issue). ...
journal_title：Science translational medicine
pub_type： 杂志文章,评审
doi：10.1126/scitranslmed.abb6700
更新日期：2020-05-06 00:00:00
abstract：:Epithelial tissues line the organs of the body, providing an initial protective barrier as well as a surface for nutrient and drug absorption. Here, we identified enzymatic components present in the gastrointestinal epithelium that can serve as selective means for tissue-directed polymerization. We focused on the smal...
journal_title：Science translational medicine
pub_type： 杂志文章
doi：10.1126/scitranslmed.abc0441
更新日期：2020-08-26 00:00:00
abstract：:The elevation of carbon dioxide (CO2) in tissues and the bloodstream (hypercapnia) occurs in patients with severe lung diseases, including chronic obstructive pulmonary disease (COPD). Whereas hypercapnia has been recognized as a marker of COPD severity, a role for hypercapnia in disease pathogenesis remains unclear. ...
journal_title：Science translational medicine
pub_type： 杂志文章
doi：10.1126/scitranslmed.aat1662
更新日期：2018-09-05 00:00:00
abstract：:Immunological and inflammatory processes downstream of dystrophin deficiency as well as metabolic abnormalities, defective autophagy, and loss of regenerative capacity all contribute to muscle pathology in Duchenne muscular dystrophy (DMD). These downstream cascades offer potential avenues for pharmacological interven...
journal_title：Science translational medicine
pub_type： 杂志文章,评审
doi：10.1126/scitranslmed.aaa7322
更新日期：2015-08-05 00:00:00
abstract：:Meibomian glands (MGs) are sebaceous glands of the eyelid margin that secrete lipids needed to avert tear evaporation and to help maintain ocular surface homeostasis. Obstruction of MGs or other forms of MG dysfunction can promote chronic diseases of the ocular surface. Although chronic eyelid inflammation, such as al...
journal_title：Science translational medicine
pub_type： 杂志文章
doi：10.1126/scitranslmed.aas9164
更新日期：2018-07-25 00:00:00
abstract：:A clinical trial evaluating HIV vaccine therapy teaches us much about optimal design (Sneller et al, this issue). ...
journal_title：Science translational medicine
pub_type： 杂志文章,评审
doi：10.1126/scitranslmed.aaq0810
更新日期：2017-12-06 00:00:00
abstract：:The recent Perspective entitled "Power of rare diseases: Found in translation" undervalues the contributions of academic research in first-in-human studies. ...
journal_title：Science translational medicine
pub_type： 评论,杂志文章
doi：10.1126/scitranslmed.3007911
更新日期：2014-01-15 00:00:00
abstract：:Understanding the biological properties of plasma cell-free DNA may expand its applications in oncology (Mouliere et al, this issue). ...
journal_title：Science translational medicine
pub_type： 评论,杂志文章,评审
doi：10.1126/scitranslmed.aav3873
更新日期：2018-11-07 00:00:00
abstract：:Troublesome involuntary movements in the absence of dopaminergic medication, so-called off-medication dyskinesias, are a serious adverse effect of fetal neural grafts that hinders the development of cell-based therapies for Parkinson's disease. The mechanisms underlying these dyskinesias are not well understood, and i...
journal_title：Science translational medicine
pub_type： 杂志文章
doi：10.1126/scitranslmed.3000976
更新日期：2010-06-30 00:00:00
abstract：:Evaluating individual research performance is a complex task that ideally examines productivity, scientific impact, and research quality--a task that metrics alone have been unable to achieve. In January 2011, the French Academy of Sciences published a report on current bibliometric (citation metric) methods for evalu...
journal_title：Science translational medicine
pub_type： 杂志文章
doi：10.1126/scitranslmed.3002249
更新日期：2011-05-25 00:00:00
abstract：:Clinical management of human cancer is dependent on the accurate monitoring of residual and recurrent tumors. The evaluation of patient-specific translocations in leukemias and lymphomas has revolutionized diagnostics for these diseases. We have developed a method, called personalized analysis of rearranged ends (PARE...
journal_title：Science translational medicine
pub_type： 杂志文章
doi：10.1126/scitranslmed.3000702
更新日期：2010-02-24 00:00:00
abstract：:As observed during the 2013-2016 Ebola virus disease epidemic, containment of filovirus outbreaks is challenging and made more difficult by the lack of approved vaccine or therapeutic options. Marburg and Ravn viruses are highly virulent and cause severe and frequently lethal disease in humans. Monoclonal antibodies (...
journal_title：Science translational medicine
pub_type： 杂志文章
doi：10.1126/scitranslmed.aai8711
更新日期：2017-04-05 00:00:00
abstract：:Whole-genome sequencing of patient DNA can facilitate diagnosis of a disease, but its potential for guiding treatment has been under-realized. We interrogated the complete genome sequences of a 14-year-old fraternal twin pair diagnosed with dopa (3,4-dihydroxyphenylalanine)-responsive dystonia (DRD; Mendelian Inherita...
journal_title：Science translational medicine
pub_type： 杂志文章
doi：10.1126/scitranslmed.3002243
更新日期：2011-06-15 00:00:00
abstract：:In acute and chronic inflammation, neutrophils and platelets, both of which promote monocyte recruitment, are often activated simultaneously. We investigated how secretory products of neutrophils and platelets synergize to enhance the recruitment of monocytes. We found that neutrophil-borne human neutrophil peptide 1 ...
journal_title：Science translational medicine
pub_type： 杂志文章
doi：10.1126/scitranslmed.aad5330
更新日期：2015-12-09 00:00:00
abstract：:There is a critical need for effective new pharmacotherapies for pain. The paucity of new drugs successfully reaching the clinic calls for a reassessment of current analgesic drug discovery approaches. Many points early in the discovery process present significant hurdles, making it critical to exploit advances in pai...
journal_title：Science translational medicine
pub_type： 杂志文章,评审
doi：10.1126/scitranslmed.3008320
更新日期：2014-08-13 00:00:00
abstract：:Measles virus is a highly infectious morbillivirus responsible for major morbidity and mortality in unvaccinated humans. The related, zoonotic canine distemper virus (CDV) induces morbillivirus disease in ferrets with 100% lethality. We report an orally available, shelf-stable pan-morbillivirus inhibitor that targets ...
journal_title：Science translational medicine
pub_type： 杂志文章
doi：10.1126/scitranslmed.3008517
更新日期：2014-04-16 00:00:00
abstract：:Venetoclax is a specific B cell lymphoma 2 (BCL-2) inhibitor with promising activity against acute myeloid leukemia (AML), but its clinical efficacy as a single agent or in combination with hypomethylating agents (HMAs), such as azacitidine, is hampered by intrinsic and acquired resistance. Here, we performed a genome...
journal_title：Science translational medicine
pub_type： 杂志文章
doi：10.1126/scitranslmed.aax2863
更新日期：2019-10-30 00:00:00
abstract：:Advances in health information technology and electronic medical records have the tremendous potential to accelerate translational and clinical research. However, privacy concerns threaten to be a rate-limiting factor. By recognizing and responding to patient privacy concerns, policy-makers, researchers, and informati...
journal_title：Science translational medicine
pub_type： 杂志文章
doi：10.1126/scitranslmed.3002037
更新日期：2011-02-09 00:00:00
abstract：:A congenital or iatrogenic tissue defect often requires closure by open surgery or metallic components that can erode tissue. Biodegradable, hydrophobic light-activated adhesives represent an attractive alternative to sutures, but lack a specifically designed minimally invasive delivery tool, which limits their clinic...
journal_title：Science translational medicine
pub_type： 杂志文章
doi：10.1126/scitranslmed.aaa2406
更新日期：2015-09-23 00:00:00
abstract：:Migraine-related photophobia is multifaceted and may be mediated by numerous pathways. ...
journal_title：Science translational medicine
pub_type： 评论,杂志文章
doi：10.1126/scitranslmed.aan8206
更新日期：2017-07-12 00:00:00
abstract：:Direct-to-consumer (DTC) advertising of suspect goods and services has burgeoned because of the Internet. Despite very limited approval for use, DTC stem cell-marketed "treatments" have emerged for an array of conditions, creating global public health and safety risks. However, it remains unclear whether such use of s...
journal_title：Science translational medicine
pub_type： 杂志文章
doi：10.1126/scitranslmed.3004030
更新日期：2012-09-12 00:00:00
