A Novel Bacteriophage Lysin-Human Defensin Fusion Protein Is Effective in Treatment of Clostridioides difficile Infection in Mice.

abstract：:Aeromonas hydrophila is responsible for aeromonad septicaemia in fish, and gastroenteritis and wound infections in humans. The type III secretion system (T3SS) is utilized by aeromonads to inject protein effectors directly into host cells. One of the major genetic regulators of the T3SS in several bacterial species is...

journal_title：Frontiers in microbiology

authors： Zhao YH,Shaw JG

更新日期：2016-09-07 00:00:00

abstract：:Chlamydia suis is a swine pathogen that has also recently been found to cause zoonotic infections of the human eye, pharynx, and gastrointestinal tract. Many strains contain a tetracycline class C gene [tet(C)] cassette that confers tetracycline resistance. The cassette was likely originally acquired by horizontal gen...

journal_title：Frontiers in microbiology

authors： Marti H,Kim H,Joseph SJ,Dojiri S,Read TD,Dean D

更新日期：2017-02-07 00:00:00

abstract：:Type VI CRISPR-Cas systems contain a single effector nuclease (Cas13) that exclusively targets single-stranded RNA. It remains unknown how these systems acquire spacers. It has been suggested that type VI systems with adaptation modules can acquire spacers from RNA bacteriophages, but sequence similarities suggest tha...

journal_title：Frontiers in microbiology

authors： Toro N,Mestre MR,Martínez-Abarca F,González-Delgado A

更新日期：2019-09-13 00:00:00

abstract：:Zinc has an abounding occurrence in the prokaryotes and plays paramount roles including catalytic, structural, and regulatory. Zinc uptake regulator (Zur), a Fur family transcriptional regulator, is connoted in maintaining zinc homeostasis in the pathogenic bacteria by binding to zinc and regulating the genes involved...

journal_title：Frontiers in microbiology

authors： Kandari D,Gopalani M,Gupta M,Joshi H,Bhatnagar S,Bhatnagar R

更新日期：2019-01-11 00:00:00

abstract：:Many DNA virus replication-related proteins are associated with promyelocytic leukemia protein (PML), a component of nuclear domain 10 (ND10), which has been investigated for its potential involvement in viral replication. In the case of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic gene products, K8 (K-bZIP), ...

journal_title：Frontiers in microbiology

authors： Hossain MG,Ohsaki E,Honda T,Ueda K

更新日期：2018-10-08 00:00:00

abstract：:To understand the contribution of animal- and human-derived fecal pollution sources in shaping integron prevalence and diversity in beach waters, 414 Escherichia coli strains were collected from beach waters (BW, n = 166), seagull feces (SF, n = 179), and wastewaters (WW, n = 69), on the World Biosphere Reserve of the...

journal_title：Frontiers in microbiology

authors： Moura A,Araújo S,Alves MS,Henriques I,Pereira A,Correia AC

更新日期：2014-08-12 00:00:00

abstract：:The conserved protein DivIVA is involved in different morphogenetic processes in Gram-positive bacteria. In Bacillus subtilis, the protein localizes to the cell division site and cell poles, and functions as a scaffold for proteins that regulate division site selection, and for proteins that are required for sporulati...

journal_title：Frontiers in microbiology

authors： Halbedel S,Kawai M,Breitling R,Hamoen LW

更新日期：2014-02-14 00:00:00

abstract：:D-amino acids (DAAs) are an important component of the refractory dissolved organic matter pool in the ocean. Microbes play a vital role in promoting the recycling of DAAs in the ocean. However, the diversity of marine DAA-utilizing bacteria and how they metabolize DAAs are seldom studied. Here, by enrichment culture ...

journal_title：Frontiers in microbiology

authors： Yu Y,Yang J,Zheng LY,Sheng Q,Li CY,Wang M,Zhang XY,McMinn A,Zhang YZ,Song XY,Chen XL

更新日期：2020-01-10 00:00:00

abstract：:Rice false smut fungus (teleomorph: Villosiclava virens; anamorph: Ustilaginoidea virens) can generate chlamydospores and survive winter under field conditions. The chlamydospore is considered as an important infection source of the disease. However, little is known about the regulatory mechanism of the chlamydospore ...

journal_title：Frontiers in microbiology

authors： Yu J,Yu M,Song T,Cao H,Pan X,Yong M,Qi Z,Du Y,Zhang R,Yin X,Liu Y

更新日期：2019-06-20 00:00:00

abstract：:Recently, novel variants of H5 highly pathogenic avian influenza viruses (AIVs) have been frequently isolated from poultry and wild birds in Asia, Europe and North America. Live poultry markets (LPMs) play an important role in the dissemination of influenza viruses. Four H5N2 AIVs were isolated from poultry during sur...

journal_title：Frontiers in microbiology

authors： Wu H,Lu R,Peng X,Peng X,Cheng L,Liu F,Wu N

更新日期：2017-04-25 00:00:00

abstract：:Bacterial conjugation is one of the most important mechanisms for spread of antibiotic resistance among bacteria. We have previously demonstrated that cefotaxime (CTX) exposure up-regulates expression of Type-IV conjugation transfer genes, and that this leads to increased transfer of a blaCTX-M-1 encoding IncI1 resist...

journal_title：Frontiers in microbiology

authors： Liu G,Olsen JE,Thomsen LE

更新日期：2019-09-24 00:00:00

abstract：:Exposure to multiple stress factors is believed to contribute to honey bee colony decline. However, little is known about how co-exposure to stress factors can alter the survival and behavior of free-living honey bees in colony conditions. We therefore studied the potential interaction between a neonicotinoid pesticid...

journal_title：Frontiers in microbiology

authors： Coulon M,Dalmon A,Di Prisco G,Prado A,Arban F,Dubois E,Ribière-Chabert M,Alaux C,Thiéry R,Le Conte Y

更新日期：2020-04-30 00:00:00

abstract：:The emergence and spread of multi-drug resistant (MDR) especially carbapenem-resistant Klebsiella pneumoniae is a major emerging threat to public health, leading to excess in mortality rate as high as 50-86%. MDR K. pneumoniae manifests all broad mechanisms of drug resistance, hence development of new drugs to treat M...

journal_title：Frontiers in microbiology

authors： Cheepurupalli L,Raman T,Rathore SS,Ramakrishnan J

更新日期：2017-04-12 00:00:00

abstract：:We explore the potential of bacterial secretion systems as tools for genomic modification of human cells. We previously showed that foreign DNA can be introduced into human cells through the Type IV A secretion system of the human pathogen Bartonella henselae. Moreover, the DNA is delivered covalently attached to the ...

journal_title：Frontiers in microbiology

authors： Guzmán-Herrador DL,Steiner S,Alperi A,González-Prieto C,Roy CR,Llosa M

更新日期：2017-08-22 00:00:00

abstract：:The DedA family is a conserved membrane protein family found in most organisms. A Burkholderia thailandensis DedA family protein, named DbcA, is required for high-level colistin (polymyxin E) resistance, but the mechanism awaits elucidation. Modification of lipopolysaccharide lipid A with the cationic sugar aminoarabi...

journal_title：Frontiers in microbiology

authors： Panta PR,Doerrler WT

更新日期：2021-01-12 00:00:00

abstract：:Agricultural intensification accelerates the degradation of cropland, and restoration has been managed by changing its vegetation. However, the keystone microbiome that drives the decomposition of plant-associated organic matter in the restoration is poorly understood. In this study, we established a 14-year field res...

journal_title：Frontiers in microbiology

authors： Zhang Z,Han X,Yan J,Zou W,Wang E,Lu X,Chen X

更新日期：2020-08-18 00:00:00

abstract：:Lentinula edodes mycelia (LEM) solid culture extracts contain many bioactive compounds with diverse pharmacological activities such as antitumor, antiviral, and immunopotentiating effects. In this study, we examined the anti-influenza virus activity of LEM in vitro and in vivo. LEM directly inhibited influenza virus g...

journal_title：Frontiers in microbiology

authors： Kuroki T,Lee S,Hirohama M,Taku T,Kumakura M,Haruyama T,Nagata K,Kawaguchi A

更新日期：2018-05-29 00:00:00

abstract：:Rhizaria are an important component of oceanic plankton communities worldwide. A number of species harbor eukaryotic microalgal symbionts, which are horizontally acquired in the environment at each generation. Although these photosymbioses are determinant for Rhizaria ability to thrive in oceanic ecosystems, the mecha...

journal_title：Frontiers in microbiology

authors： Balzano S,Corre E,Decelle J,Sierra R,Wincker P,Da Silva C,Poulain J,Pawlowski J,Not F

更新日期：2015-03-17 00:00:00

abstract：:Acinetobacter baumannii is emerging as a challenging nosocomial pathogen due to its rapid evolution of antibiotic resistance. We report characterization of two novel bacteriophages, PBAB08 and PBAB25, infecting clinically isolated, multidrug-resistant (MDR) A. baumannii strains. Both phages belonged to Myoviridae of C...

journal_title：Frontiers in microbiology

authors： Cha K,Oh HK,Jang JY,Jo Y,Kim WK,Ha GU,Ko KS,Myung H

更新日期：2018-04-10 00:00:00

abstract：:A notable feature of the Deepwater Horizon oil spill was the unprecedented formation of marine oil snow (MOS) that was observed in large quantities floating on the sea surface and that subsequently sedimented to the seafloor. Whilst the physical and chemical processes involved in MOS formation remain unclear, some stu...

journal_title：Frontiers in microbiology

authors： Suja LD,Chen X,Summers S,Paterson DM,Gutierrez T

更新日期：2019-03-20 00:00:00

abstract：:Aspergillus diseases are often caused by Aspergillus fumigatus. Azoles are the mainstay of therapy, but the management of aspergillosis is hampered by the emergence of azole resistance. Rapid detection of azole resistance might benefit treatment outcome by early treatment modifications. However, the yield of fungal cu...

journal_title：Frontiers in microbiology

authors： Buil JB,Zoll J,Verweij PE,Melchers WJG

更新日期：2018-03-21 00:00:00

abstract：:Toxoplasma gondii rhoptry proteins (TgROPs) are the major targets as key molecules for immunodiagnosis as well as immunoprophylaxis because of their initial presentation to the host immune system. In this work, it was aimed at evaluating the protection effect of TgROP21 DNA vaccine on experimental mice subjected to T....

journal_title：Frontiers in microbiology

authors： Zhang Z,Li Y,Wang M,Xie Q,Li P,Zuo S,Kong L,Wang C,Wang S

更新日期：2018-05-08 00:00:00

abstract：:A Gram-positive, coccoid, motile, aerobic bacterium, designated strain B12T was isolated from a Jet Propulsion Laboratory spacecraft assembly cleanroom, Pasadena, CA, United States. Strain B12T was resistant to chloramphenicol (100 μg/mL), and is a relatively slow grower (3-5 days optimal). Strain B12T was found to gr...

journal_title：Frontiers in microbiology

authors： Mhatre S,Singh NK,Wood JM,Parker CW,Pukall R,Verbarg S,Tindall BJ,Neumann-Schaal M,Venkateswaran K

更新日期：2020-08-18 00:00:00

abstract：:Lactic acid bacteria (LAB) are important for human health. However, the relative abundance of LAB in complex samples, such as fecal samples, is low and their presence and diversity (at the species level) is understudied. Therefore, we designed LAB-specific primer pairs based on 16S rRNA gene consensus sequences from 4...

journal_title：Frontiers in microbiology

authors： Hou Q,Bai X,Li W,Gao X,Zhang F,Sun Z,Zhang H

更新日期：2018-08-31 00:00:00

abstract：:The central nervous system (CNS) barriers are highly specialized cellular barriers that promote brain homeostasis while restricting pathogen and toxin entry. The primary cellular constituent regulating pathogen entry in most of these brain barriers is the brain endothelial cell (BEC) that exhibits properties that allo...

journal_title：Frontiers in microbiology

authors： Kim BJ,Shusta EV,Doran KS

更新日期：2019-06-13 00:00:00

abstract：:Carbapenem-resistant Acinetobacter baumannii (CRAB) are emerging worldwide. In South America, clinical isolates presenting such a phenotype usually do not belong to the globally distributed international clone 2 (IC2). The majority of these isolates are also resistant to multiple other antimicrobials and are often des...

journal_title：Frontiers in microbiology

authors： Nodari CS,Cayô R,Streling AP,Lei F,Wille J,Almeida MS,de Paula AI,Pignatari ACC,Seifert H,Higgins PG,Gales AC

更新日期：2020-11-30 00:00:00

abstract：:High-throughput sequencing (HTS) techniques are of great value for the investigation of microbial communities, and have been extensively used to study the gut microbiome. While most studies focus on the human gut, many others have investigated insects. However, because of the rapid spread of HTS techniques, a lot of v...

journal_title：Frontiers in microbiology

authors： De Cock M,Virgilio M,Vandamme P,Augustinos A,Bourtzis K,Willems A,De Meyer M

更新日期：2019-12-13 00:00:00

abstract：:RNA silencing mediated by microRNAs (miRNAs) is a recently discovered gene regulatory mechanism involved in various aspects of biology, such as development, cell differentiation and proliferation, and innate immunity against viral infections. miRNAs, which are a class of small (21-25 nucleotides) RNAs, target messenge...

journal_title：Frontiers in microbiology

authors： Tsunetsugu-Yokota Y,Yamamoto T

更新日期：2010-10-13 00:00:00

abstract：:The response of methanogens to thawing permafrost is an important factor for the global greenhouse gas budget. We tracked methanogenic community structure, activity, and abundance along the degradation of sub-Arctic palsa peatland permafrost. We observed the development of pronounced methane production, release, and a...

journal_title：Frontiers in microbiology

authors： Liebner S,Ganzert L,Kiss A,Yang S,Wagner D,Svenning MM

更新日期：2015-05-12 00:00:00

abstract：:Although complete genome sequences hold particular value for an accurate description of core genomes, the identification of strain-specific genes, and as the optimal basis for functional genomics studies, they are still largely underrepresented in public repositories. Based on an assessment of the genome assembly comp...

journal_title：Frontiers in microbiology

authors： Schmid M,Muri J,Melidis D,Varadarajan AR,Somerville V,Wicki A,Moser A,Bourqui M,Wenzel C,Eugster-Meier E,Frey JE,Irmler S,Ahrens CH

更新日期：2018-01-30 00:00:00