Abstract:
:Recently, novel variants of H5 highly pathogenic avian influenza viruses (AIVs) have been frequently isolated from poultry and wild birds in Asia, Europe and North America. Live poultry markets (LPMs) play an important role in the dissemination of influenza viruses. Four H5N2 AIVs were isolated from poultry during surveillance of AIVs in LPMs in Eastern China, in 2015. Whole-genome sequencing, combined with phylogenetic and antigenic analyses were performed to characterize these viruses. These H5N2 viruses had undergone extensive reassortment resulting in two genetic groups of viruses in poultry. These viruses exhibited slightly pathogenicity in mice, and replicated without prior adaptation. The continued circulation of these novel H5N2 viruses may represent a threat to human health.
journal_name
Front Microbioljournal_title
Frontiers in microbiologyauthors
Wu H,Lu R,Peng X,Peng X,Cheng L,Liu F,Wu Ndoi
10.3389/fmicb.2017.00741subject
Has Abstractpub_date
2017-04-25 00:00:00pages
741issn
1664-302Xjournal_volume
8pub_type
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