Abstract：
:Tebuconazole is a triazole compound used agriculturally to treat plant pathogenic fungi. However, whether pubertal exposure to tebuconazole affects Leydig cell development remains unknown. Here, we exposed male Sprague-Dawley rats at 35 days of age to 0, 25, 50, or 100 mg kg-1 day-1 tebuconazole for 21 days. Tebuconazole exposure increased serum testosterone level but lowered estradiol level at a dose of 100 mg kg-1, without affecting serum luteinizing hormone and follicle-stimulating hormone concentrations. Tebuconazole up-regulated the expression of testicular Cyp11a1, Hsd11b1, and Fshr genes as well as their proteins at a dose of 100 mg kg-1. However, tebuconazole did not stimulate the proliferation of Leydig cells. Tebuconazole in vitro inhibits aromatase activity in primary rat Leydig cells with IC50 value of 40 μmol/L. In conclusion, tebuconazole exposure stimulates pubertal Leydig cell differentiation via inhibiting aromatase activity.
journal_name
Chemospherejournal_title
Chemosphereauthors
Chen X,Zhu Q,Li X,Huang T,Wang S,Wang Y,Chen X,Lin Z,Ge RSdoi
10.1016/j.chemosphere.2019.05.122subject
Has Abstractpub_date
2019-09-01 00:00:00pages
519-526eissn
0045-6535issn
1879-1298pii
S0045-6535(19)31028-8journal_volume
230pub_type
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