Abstract:
:Recent trials have shown that recombinant tissue plasminogen activator (rt-PA) is an effective thrombolytic agent in patients with acute myocardial infarction. Because rt-PA converts plasminogen to plasmin, which is known to activate complement in vitro, we tested the hypothesis that rt-PA can induce in vivo activation of complement. Studies were performed in 12 patients with acute myocardial infarction. Six control patients had patent coronary arteries and did not receive rt-PA; these patients had normal values of the components of the complement system C4a (409 +/- 111 ng/ml) and C5a (8.8 +/- 1.8 ng/ml) with a slight elevation of C3a (204 +/- 6.6 ng/ml) in samples collected before coronary arteriography (253 +/- 25 minutes after onset of pain). After coronary arteriography, there was a slight decrease in the values of C4a (224 +/- 37 ng/ml), C5a (7.3 +/- 1.3 ng/ml) and C3a (164 +/- 35 ng/ml). The remaining six patients had complete coronary occlusion and received rt-PA (80 to 150 mg intravenously). In this treated group, before coronary arteriography the values of C4a (406 +/- 51.6 ng/ml) and C5a (8.1 +/- 1.9 ng/ml) were normal, and those of C3a were slightly elevated (250 +/- 76 ng/ml). All complement values obtained before rt-PA were similar to those in the untreated group. However, after administration of rt-PA (but before any angiographically detectable reperfusion), there was a striking increase in C4a (2,265 +/- 480 ng/ml; p less than 0.01), C3a (600 +/- 89 ng/ml; p less than 0.05) and C5a (30.0 +/- 4.5 ng/ml; p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Bennett WR,Yawn DH,Migliore PJ,Young JB,Pratt CM,Raizner AE,Roberts R,Bolli Rdoi
10.1016/s0735-1097(87)80206-1subject
Has Abstractpub_date
1987-09-01 00:00:00pages
627-32issue
3eissn
0735-1097issn
1558-3597pii
S0735-1097(87)80206-1journal_volume
10pub_type
杂志文章abstract:BACKGROUND:The risk-benefit ratio of left atrial appendage closure (LAAC) versus systemic therapy (warfarin) for prevention of stroke, systemic embolism, and cardiovascular death in nonvalvular atrial fibrillation (NVAF) requires continued evaluation. OBJECTIVES:This study sought to assess composite data regarding lef...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,meta分析
doi:10.1016/j.jacc.2015.04.025
更新日期:2015-06-23 00:00:00
abstract:OBJECTIVES:We sought to determine a generalized equation for predicting maximal heart rate (HRmax) in healthy adults. BACKGROUND:The age-predicted HRmax equation (i.e., 220 - age) is commonly used as a basis for prescribing exercise programs, as a criterion for achieving maximal exertion and as a clinical guide during...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,meta分析
doi:10.1016/s0735-1097(00)01054-8
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Patients with high stroke risk and atrial fibrillation who are unsuitable to oral anticoagulants (OACs) require other stroke prevention strategies. A novel permanent coil filter directly placed into both common carotid arteries (CCAs) was designed to capture emboli >1.4 mm in diameter. OBJECTIVES:The multic...
journal_title:Journal of the American College of Cardiology
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doi:10.1016/j.jacc.2019.04.035
更新日期:2019-08-20 00:00:00
abstract:OBJECTIVES:The purpose of this study was to determine whether the induction at electrophysiologic study of sustained monomorphic ventricular tachycardias with multiple QRS complex configurations predicted failure of subsequent serial electrophysiologic study guided antiarrhythmic drug testing. BACKGROUND:Ventricular t...
journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章
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journal_title:Journal of the American College of Cardiology
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更新日期:2003-11-05 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(99)00506-9
更新日期:2000-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-01-05 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(88)90368-3
更新日期:1988-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-11-15 00:00:00
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doi:10.1016/j.jacc.2009.11.051
更新日期:2010-03-16 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:2019-04-30 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2003.12.045
更新日期:2004-05-19 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0735-1097(03)00483-2
更新日期:2003-06-18 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1016/s0735-1097(02)02822-x
更新日期:2003-02-05 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(86)80356-4
更新日期:1986-04-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2004-09-15 00:00:00
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更新日期:2017-09-26 00:00:00
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更新日期:2020-05-12 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2000-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0735-1097(93)90597-t
更新日期:1993-11-15 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2019-10-22 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:1997-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jacc.2005.02.054
更新日期:2005-05-17 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:1991-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-11-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:2011-11-08 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/0735-1097(88)92597-1
更新日期:1988-11-01 00:00:00