Cytopathology of anaplastic carcinoma of the pancreas: Review of a rare entity and description of a variant with signet ring cell features.

Abstract:

:Anaplastic carcinoma of the pancreas (ACP) is a rare and aggressive variant of pancreatic ductal adenocarcinoma (PDAC). Several studies have attempted to characterize this subtype through case series or single case reports; however, ACP remains underrecognized by cytopathologists in particular, and often lumped under the umbrella of classic PDAC. Here, we review the most up to date data that literature provides about ACP, to bring familiarity with this entity to the cytopathology practice, and to elucidate the role cytopathologists can play in recognizing and diagnosing this subtype on pancreatic aspiration biopsy, before surgical resection. We also describe a rare case of ACP, demonstrating signet ring cell features, that was diagnosed on fine needle aspiration of a pancreatic mass.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

El Hussein S,Khader SN

doi

10.1002/dc.24263

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

956-960

issue

9

eissn

8755-1039

issn

1097-0339

journal_volume

47

pub_type

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