Utility of fine needle aspiration cytology to diagnose intraoral tuberculosis and other oral granulomatous lesions.


OBJECTIVE:Tuberculosis (TB) is a common granulomatous disease leading to high morbidity and mortality worldwide. Though rare, oral tuberculosis (OTB) may manifest during the primary and/or secondary stages of the illness. We studied the manifestations and incidence of oral granulomatous lesions (OGL) and OTB diagnosed on fine needle aspiration cytology (FNAC). STUDY DESIGN:In this retrospective study, we present a review of 149 cases of benign and inflammatory lesions of oral mucosa diagnosed between 2008 and 2016. RESULT:Of the 280 oral FNAC performed during the 9 y study period, 149 cases were diagnosed as benign and inflammatory lesions among which 12 (4.3%) showed granulomatous lesions. Four out of 12 cases were diagnosed as OTB. One (0.011%) was a case of Primary OTB with no associated pulmonary or extrapulmonary manifestations of TB and three had associated lymphadenopathy including one with pulmonary TB. Per the clinical records, all four patients responded well to anti tubercular treatment (ATT) rendered under directly observed treatment short course (DOTS) supervision with regular visits and monitoring. CONCLUSIONS:Although oral mucosal TB is a rare presentation, clinicians and pathologists need to consider it early in the differential diagnosis of primary and secondary oral mucosal lesions. Such patients should be further evaluated for pulmonary TB and tuberculous lymphadenitis.


Diagn Cytopathol


Diagnostic cytopathology


Agarwal R,Singh M,Sharma S,Jaiswal A,Jain SL,Khurana N,Meher R




Has Abstract


2019-03-01 00:00:00












  • Ovarian carcinoma cells in effusions show increased S-phase fraction compared to corresponding primary tumors.

    abstract::The objective of this study was to analyze large-scale genomic patterns during disease progression from primary tumor to effusion in ovarian carcinoma, and to study the association between DNA ploidy parameters in effusions, proliferation/survival markers, and clinicopathologic characteristics. DNA ploidy status, DNA ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Kleinberg L,Pradhan M,Tropé CG,Nesland JM,Davidson B,Risberg B

    更新日期:2008-09-01 00:00:00

  • Pericardial effusion as primary manifestation of metastatic cutaneous adenoid cystic carcinoma: diagnostic cytopathology from an exfoliative sample.

    abstract::Adenoid cystic carcinoma (ACC) occurs not only as a tumor of salivary glands, but also in very unusual locations, such as in the skin. Only very few cases of primary cutaneous of ACC have metastasized to the lymph nodes and lungs. We present a 53-year-old man with metastasis of the pericardium from a primary cutaneous...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Benchetritt M,Butori C,Long E,Ilie M,Ferrari E,Hofman P

    更新日期:2008-05-01 00:00:00

  • Detection of malignant effusions: comparison of a telomerase assay and cytologic examination.

    abstract::Telomerase is inactive in most somatic cells, but has been found to be reactivated in a majority of cancers. Our principal goal was to test whether the presence of telomerase activity concurred with positive cytology, and was thus of potential use in detecting cancer cells in effusions. The telomeric repeat amplificat...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Braunschweig R,Yan P,Guilleret I,Delacretaz F,Bosman FT,Mihaescu A,Benhattar J

    更新日期:2001-03-01 00:00:00

  • Scrape cytology of pemphigus vulgaris of the nipple, a mimicker of Paget's disease.

    abstract::A case of histologically and immunocytochemically confirmed pemphigus vulgaris of the nipple examined by scrape cytology is reported. The scrape cytology showed isolated and somewhat loosely clustered cells with basophilic cytoplasm and vesicular hyperchromatic nuclei dysplaying prominent nucleoli, suggesting Paget's ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Kobayashi TK,Ueda M,Nishino T,Kibe S,Higashida T,Watanabe S

    更新日期:1997-02-01 00:00:00

  • Preoperative diagnosis of well-differentiated neuroendocrine tumor in common hepatic duct by brush cytology: A case report.

    abstract::The biological behavior of neuroendocrine tumors (NETs) is heterogeneous and differs from that of cholangiocarcinoma, which is the most common malignant tumor of the biliary tree. However, the preoperative diagnosis of NET in the biliary tree is extremely difficult and to our knowledge, diagnosis by brush cytology has...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Choi J,Lee KJ,Kim SH,Cho MY

    更新日期:2019-07-01 00:00:00

  • The role of endoscopic ultrasound and endoscopic ultrasound-guided fine-needle aspiration in distinguishing pancreatic cystic lesions.

    abstract::Distinguishing mucinous from nonmucinous cystic lesions of the pancreas often constitutes a diagnostic dilemma. The clinical management differs between such lesions; therefore it is important to make an accurate preoperative diagnosis. Various centers have reported conflicting results regarding their ability to detect...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Moparty B,Logroño R,Nealon WH,Waxman I,Raju GS,Pasricha PJ,Bhutani MS

    更新日期:2007-01-01 00:00:00

  • Adult ocular medulloepithelioma diagnosed by transscleral fine needle aspiration: A case report.

    abstract::Ocular medulloepithelioma (ME) is a rare congenital tumor which occurs usually during childhood but is also reported in adults. They have seen an intraocular tumor in an 89 years-old female with a history of small cell lung carcinoma. Transscleral fine needle aspiration was performed. Aspirates were rich and composed ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Mahdjoubi A,Cassoux N,Levy-Gabriel C,Desjardins L,Klos J,Caly M,Vlajnic T,Gardrat S,Klijanienko J

    更新日期:2017-06-01 00:00:00

  • Simultaneous cytological diagnosis of herpes simplex virus infection and primary lung cancer: report of two cases.

    abstract::Herpes simplex is an uncommon cause of lower respiratory tract infection that requires prompt diagnosis and treatment to prevent late complications. We report two cases with simultaneous herpes simplex virus infection of the lower respiratory tract and lung carcinoma. Cytology of bronchial brushing and washing fluids ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Maounis N,Blana A,Ellina E,Chorti M,Lekkakou A,Mermigkis D,Spanakis N,Emmanouilidou A

    更新日期:2008-11-01 00:00:00

  • Pitfalls in the cytological diagnosis of tenosynovial giant cell tumor: An illustration of eight discordant cases.

    abstract::Tenosynovial giant cell tumor (TSGCT) is a highly recurrent benign tumor of the extremities. Wide local excision is usually sufficient to achieve its recurrence-free outcome. However, that needs a confident pre-operative cytological diagnosis as TSGCT. Aspirates from this tumor express the characteristic polymorphic c...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Mondal K,Mandal R,Khan K,Chakraborty J

    更新日期:2018-03-01 00:00:00

  • Diffuse large B-cell lymphoma with fibrillary matrix.

    abstract::Diffuse large B-cell lymphoma (DLBCL) with fibrillary matrix is an extremely rare variant of non-Hodgkin's lymphoma (NHL) whose pathological features are poorly known. Here, we report on our experience with such a condition arising in a 71-yr-old woman. Our findings not only demonstrate that DLBCL with fibrillary matr...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Dargent JL,Meiers I,Lespagnard L,Ma Y,Dehou MF,Verhest A

    更新日期:2002-10-01 00:00:00

  • Immunostaining of estrogen receptor, progesterone receptor, MIB1 antigen, and c-erbB-2 oncoprotein in cytologic specimens: a simplified method with formalin fixation.

    abstract::An effective but simple fixation protocol for the immunocytochemical staining of cytologic smears for estrogen and progesterone receptors, the Ki-67 antigen (using MIB1 antibody), and c-erbB-2 protein is described. One hundred twenty-seven smears from a variety of malignant and benign breast lesions showed good preser...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Suthipintawong C,Leong AS,Chan KW,Vinyuvat S

    更新日期:1997-08-01 00:00:00

  • Sources of diagnostic discrepancies in fine-needle aspiration of the breast.

    abstract::Fine-needle aspiration (FNA) is a valuable technique to use in the evaluation of breast lesions; however, inadequate and discrepant diagnoses do occur. To identify the source and nature of inaccuracies related to the method we studied 39 cases in which FNA posed diagnostic problems. These problems could be attributed ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Scopa CD,Koukouras D,Androulakis J,Bonikos D

    更新日期:1991-01-01 00:00:00

  • A comparative needle study: EUS-FNA procedures using the HD ProCore(™) and EchoTip(®) 22-gauge needle types.

    abstract::The specific needle sizes/types used in performing endoscopic ultrasound-guided fine needle aspirations (EUS-FNA) vary. The HD ProCore(™) is a 22-gauge beveled needle allowing for core biopsy along with aspiration material. In this study we compare this needle with a standard 22-gauge needle. Between April 1, 2011 and...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Witt BL,Adler DG,Hilden K,Layfield LJ

    更新日期:2013-12-01 00:00:00

  • Liquid fixation of endometrial brush cytology ensures a well-preserved, representative cell sample with frequent tissue correlation.

    abstract::Endometrium was obtained by brushing 656 hysterectomy specimens with a MedScand cytobrush (Hollywood, FL) in order to evaluate linking an easy-to-use liquid fixative with brush-sampling of the endometrium, and to determine the fixative's operating characteristics when applied to brush-sampling the endometrium. Liquid-...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Maksem JA,Knesel E

    更新日期:1996-06-01 00:00:00

  • E-cadherin cell-adhesion molecule expression as a diagnostic adjunct in urothelial cytology.

    abstract::E-cadherin (E-CD) is a cell-adhesion molecule that has been associated with invasion and metastasis in a wide variety of human neoplasms. We have recently shown that, although decreased E-CD expression is associated with increased bladder-wall invasion and higher tumor grade of infiltrating transitional cell carcinoma...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Ross JS,Cheung C,Sheehan C,del Rosario AD,Bui HX,Fisher HA

    更新日期:1996-06-01 00:00:00

  • Flow cytometric S-phase fraction as a complementary biological parameter for the cytological grading of non-Hodgkin's lymphoma.

    abstract::Fine-needle aspiration cytology (FNAC) is a technique that can overcome tissue-sampling disaggregation problems related to DNA flow cytometry analysis. The aim of this study, with long-term follow-up (median, 72 mo), was to investigate the prognostic value of DNA ploidy and S-phase fraction (SPF) in patients with non-...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Pinto AE,Cabeçadas J,Nóbrega SD,Mendonça E

    更新日期:2003-10-01 00:00:00

  • Fine-needle aspiration cytology of lipoblastoma: a report of two cases.

    abstract::Lipoblastoma is an uncommon lipomatous tumor that typically occurs in infants and children. It may present as a single subcutaneous nodule or with multiple lesions (lipoblastomatosis). We describe fine-needle aspiration (FNA) cytologic features of two cases that presented as a subcutaneous lump in the scapular area an...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: López-Ferrer P,Jiménez-Heffernan JA,Yébenes L,Vicandi B,Viguer JM

    更新日期:2005-01-01 00:00:00

  • Localized primary amyloid tumor associated with osseous metaplasia presenting as bilateral breast masses: cytologic and radiologic features.

    abstract::This report details the cytologic features of primary localized amyloid tumor of the breast presenting as bilateral breast masses in a 72-yr-old woman. Clinically and radiographically, the masses simulated metastatic or multifocal carcinoma. Fine-needle aspiration revealed irregular globules of acellular amorphous mat...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Lynch LA,Moriarty AT

    更新日期:1993-10-01 00:00:00

  • Bleeding from Wharton's duct after fine-needle aspiration biopsy on submandibular gland.

    abstract::The case of a fine-needle aspiration biopsy (FNAB) of the patient's salivary gland lesions is considered a rapid, simple, reliable, minimal invasive procedure with markedly rare complications. Herein, we report a case of bleeding from the region of the Wharton's duct after a procedure of a FNAB on the patient's subman...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Lee DH,Yoon TM,Lee JK,Lim SC

    更新日期:2018-11-01 00:00:00

  • Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): diagnosis with fine-needle aspiration in a case with nodal and nasal involvement.

    abstract::Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare entity characterized by the proliferation of cells belonging to the macrophage-histiocyte family, but whose exact origin is unknown. A case of SHML occurring in a 62-yr-old female is described in which the diagnosis is initially suggested by fine-needle...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Alvarez Alegret R,Martinez Tello A,Ramirez T,Gállego P,Martinez D,García Julían G

    更新日期:1995-11-01 00:00:00

  • Parachordoma or chordoma periphericum? Case report of a tumor of the thoracic wall.

    abstract::We report the findings from an aspiration biopsy and resection of a chordoma-like tumorous mass in the wall of the thorax of a 36-yr-old man with immunohistochemical, ultrastructural, and cytogenetic studies. The 4-cm oval tumor was an incidental finding on physical examination, and no other lesions were identified af...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Tong G,Perle MA,Desai P,Kumar A,Waisman J

    更新日期:2003-07-01 00:00:00

  • Vaginal fine-needle aspiration: A useful alternative to biopsy.

    abstract:BACKGROUND:Vaginal fine-needle aspiration (FNA) is infrequently performed to assess palpable lesions. We perform the first multi-institutional study to evaluate this procedure. METHODS:We retrospectively reviewed vaginal FNAs performed at two institutions for the past 27 years. Clinical, cytological and histological d...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Lin DM,Barkan GA,Chatt G,Park JW,Gattuso P

    更新日期:2016-08-01 00:00:00

  • Cytological diagnosis of osteoblastoma of cervical spine: a case report with review of literature.

    abstract::Osteoblastomas are rare benign but sometimes aggressive primary bone tumors (1%), usually seen in males in the 2nd decade. Osteoblastomas, occurring in the spine, constitute a medical emergency due to impending cord compression. Hence a rapid and simple diagnostic modality, such as fine-needle aspiration (FNA) plays a...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Venugopal SB,Prasad S

    更新日期:2015-03-01 00:00:00

  • Fine-needle aspiration cytology of extramedullary hematopoiesis (myeloid metaplasia).

    abstract::Myeloproliferative disease may be associated with extramedullary hematopoiesis (EH). Clinically, however, the differential diagnosis of solid masses in these patients includes not only EH but also inflammatory lesions and malignant neoplasms, including granulocytic sarcoma. We report the fine-needle aspiration (FNA) c...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Raab SS,Silverman JF,McLeod DL,Geisinger KR

    更新日期:1993-10-01 00:00:00

  • Diagnostic value of AgNOR method in thyroid cytopathology: correlation with morphometric measurements.

    abstract::A silver staining technique was applied to 51 thyroid smears. The numbers of silver-stained nucleolar organizer regions (AgNORs) were counted, and the mean AgNOR and nuclear area per cell were determined with an image analyzer. The mean AgNOR count per cell was significantly higher in malignant than in benign lesions,...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Solymosi T,Tóth V,Sápi Z,Bodó M,Gál I,Csanádi L

    更新日期:1996-03-01 00:00:00

  • Foamy alveolar casts: diagnostic specificity for Pneumocystis carinii pneumonia in bronchoalveolar lavage fluid cytology.

    abstract::Pneumocystis carinii pneumonia (PCP) is a major infectious complication of immunodeficiency states, including the acquired immunodeficiency syndrome (AIDS). Bronchoalveolar lavage (BAL) is a safe and effective procedure for making this diagnosis. In addition to the characteristic organisms, both histologic and cytolog...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Stanley MW,Henry MJ,Iber C

    更新日期:1988-01-01 00:00:00

  • FNA diagnosis of a metastatic papillary thyroid carcinoma arising from a previously unknown follicular variant of papillary thyroid microcarcinoma.

    abstract::While metastatic tumors to bone or lymph nodes from previously known primaries are often successfully diagnosed via fine-needle aspiration (FNA), a metastatic deposit in a patient with no previously known cancer may pose a diagnostic dilemma. Here, we present a case of metastatic papillary thyroid carcinoma that prese...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Jedrzkiewicz J,Witt BL

    更新日期:2014-08-01 00:00:00

  • Intraoperative cytologic diagnosis of granulomas: a retrospective study of 156 cases.

    abstract::To avoid contamination of equipment and reduce risks of infection, intraoperative cytology (IOC) is a useful substitute to conventional frozen section in the diagnosis of infectious diseases. One of the various histomorphologic patterns of infections is the granuloma, which sometimes may be difficult to diagnose cytol...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Eltoum IA,Tabbara S

    更新日期:1998-01-01 00:00:00

  • Primary pulmonary Hodgkin's lymphoma: a rare pitfall in transthoracic fine needle aspiration cytology.

    abstract::Primary pulmonary Hodgkin's lymphoma (PPHL) is extremely rare. At an extranodal location such as the lung this lymphoma is likely to be confused with the more commonly occurring carcinomas at this site. We report the fine needle aspiration cytology (FNAC) findings of a PPHL in a 36-year-old male with a view to discuss...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Kumar R,Sidhu H,Mistry R,Shet T

    更新日期:2008-09-01 00:00:00

  • Aspiration cytodiagnosis of amyloid from vitreous fluid.

    abstract::Amyloidosis of the vitreous body is a rare disorder that causes progressive visual loss. In this report, a 36-yr-old female with familial amyloidosis is described in whom a progressive reduction of vision in both eyes over the last 4 yr was ascribed to vitreous opacities due to amyloid. A left pars plana vitrectomy wa...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Gupta RK,Wakefield J,Halliwell T,Foo K,Lallu S,Naran S,Fauck R

    更新日期:2002-05-01 00:00:00