当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Haemodynamic effects of combined oral nifedipine and sublingual nitroglycerin in patients with chronic stable angina.

Haemodynamic effects of combined oral nifedipine and sublingual nitroglycerin in patients with chronic stable angina.

Abstract：

:We examined the pharmacokinetics of nifedipine after acute and sustained oral therapy and the potential haemodynamic interaction between nifedipine and sublingual nitroglycerin in nine patients with chronic stable angina. Nifedipine pharmacokinetics after a single oral dose and sustained dosing (three times daily for five days) were not significantly different. Single dose nifedipine produced a statistically significant decrease in standing and supine systolic and diastolic blood pressures when compared to placebo. A significant decrease in the supine systolic pressure was observed after sustained nifedipine therapy. Except for this change, other hypotensive effects of nifedipine after sustained therapy were not different to those of placebo, in spite of persistent plasma nifedipine concentrations after repeated dosing. There were no observable correlations between nifedipine haemodynamics and pharmacokinetics in these patients, nor were there any significant haemodynamic interactions between sublingual nitroglycerin with either acute or sustained nifedipine treatment. The transient haemodynamic effects of sublingual nitroglycerin were not potentiated by either acute or sustained nifedipine therapy.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Boje KM,Fung HL,Yoshitomi K,Parker JO

doi

10.1007/BF00637629

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

349-54

issue

4

eissn

0031-6970

issn

1432-1041

journal_volume

33

pub_type

临床试验,杂志文章,随机对照试验

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