Abstract:
Objectives:To explore the microbiome of the prostatic fluid in high prostate-specific antigen (PSA) patients. Patients and Methods:The microbiome profiles of prostatic fluid samples from 32 prostate cancer (PCa) patients and 27 non-PCa people were assessed. Microbiome analysis was assessed by massive 16S ribosomal RNA gene sequencing. Results:Compared with the NCA group, the microbial diversity was lower in the CA group. There were no specific microbial species in the CA group or NCA group. However, many species, such as those in the genera Alkaliphilus, Enterobacter, Lactococcus, Cronobacter, Carnobacterium, and Streptococcus, showed a significant difference between the CA group and NCA group. Conclusion:The prostate contains reduced bacteria, suggesting a possible pathophysiological correlation between the composition of the microbiome and PCa. Meanwhile, this study uncovered that the microbiome may be beneficial in maintaining the stability of the microenvironment of the prostate and provides interesting perspectives for the identification of novel biomarkers in high-PSA patients.
journal_name
Front Microbioljournal_title
Frontiers in microbiologyauthors
Ma X,Chi C,Fan L,Dong B,Shao X,Xie S,Li M,Xue Wdoi
10.3389/fmicb.2019.01664subject
Has Abstractpub_date
2019-07-19 00:00:00pages
1664issn
1664-302Xjournal_volume
10pub_type
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