Hybrid Capture-Based Next Generation Sequencing and Its Application to Human Infectious Diseases.


:This review describes target-enrichment approaches followed by next generation sequencing and their recent application to the research and diagnostic field of modern and past infectious human diseases caused by viruses, bacteria, parasites and fungi.


Front Microbiol


Gaudin M,Desnues C




Has Abstract


2018-11-27 00:00:00








  • Klebsiella Phage KP34 RNA Polymerase and Its Use in RNA Synthesis.

    abstract::We have characterized the single subunit RNA polymerase from Klebsiella phage KP34. The enzyme is unique among known bacteriophage RNA polymerases in that it recognizes two unrelated promoter sequences, which provided clues for the evolution of phage single-subunit RNA polymerases. As the first representative enzyme f...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Lu X,Wu H,Xia H,Huang F,Yan Y,Yu B,Cheng R,Drulis-Kawa Z,Zhu B

    更新日期:2019-10-31 00:00:00

  • Bacterial Subspecies Variation and Nematode Grazing Change P Dynamics in the Wheat Rhizosphere.

    abstract::Low phosphorus soils are thought to constitute the majority of soils worldwide and cannot support intensive agriculture without high fertilizer inputs. Rhizobacteria are well-known to modify P dynamics and an increased bacterial diversity normally has a positive impact on various process rates. However, it is not know...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Irshad U,Yergeau E

    更新日期:2018-09-05 00:00:00

  • Molecular Mechanisms and Epidemiology of Fosfomycin Resistance in Staphylococcus aureus Isolated From Patients at a Teaching Hospital in China.

    abstract::Staphylococcus aureus is a major cause of hospital- and community-acquired infections placing a significant burden on the healthcare system. With the widespread of multidrug-resistant bacteria and the lack of effective antibacterial drugs, fosfomycin has gradually attracted attention as an "old drug." Thus, investigat...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Xu W,Chen T,Wang H,Zeng W,Wu Q,Yu K,Xu Y,Zhang X,Zhou T

    更新日期:2020-06-26 00:00:00

  • Anilinopyrimidine Resistance in Botrytis cinerea Is Linked to Mitochondrial Function.

    abstract::Crop protection anilinopyrimidine (AP) fungicides were introduced more than 20 years ago for the control of a range of diseases caused by ascomycete plant pathogens, and in particular for the control of gray mold caused by Botrytis cinerea. Although early mode of action studies suggested an inhibition of methionine bi...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Mosbach A,Edel D,Farmer AD,Widdison S,Barchietto T,Dietrich RA,Corran A,Scalliet G

    更新日期:2017-11-30 00:00:00

  • Multi-Method Characterization of the Human Circulating Microbiome.

    abstract::The term microbiome describes the genetic material encoding the various microbial populations that inhabit our body. Whilst colonization of various body niches (e.g., the gut) by dynamic communities of microorganisms is now universally accepted, the existence of microbial populations in other "classically sterile" loc...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Whittle E,Leonard MO,Harrison R,Gant TW,Tonge DP

    更新日期:2019-01-17 00:00:00

  • PP2A-Like Protein Phosphatase (Sit4) Regulatory Subunits, Sap155 and Sap190, Regulate Candida albicans' Cell Growth, Morphogenesis, and Virulence.

    abstract::PP2A-like phosphatases share high homology with PP2A enzymes and are composed of a catalytic subunit and a regulatory subunit. In Candida albicans, the PP2A-like catalytic subunit SIT4 regulates cell growth, morphogenesis, and virulence. However, the functions of its regulatory subunits remain unclear. Here, by homolo...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Han Q,Pan C,Wang Y,Zhao L,Wang Y,Sang J

    更新日期:2019-12-20 00:00:00

  • GTP-Dependent FlhF Homodimer Supports Secretion of a Hemolysin in Bacillus cereus.

    abstract::The multidomain (B-NG) protein FlhF, a flagellar biogenesis regulator in several bacteria, is the third paralog of the signal recognition particle (SRP)-GTPases Ffh and FtsY, which are known to drive protein-delivery to the plasma membrane. Previously, we showed that FlhF is required for Bacillus cereus pathogenicity ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Mazzantini D,Fonnesu R,Celandroni F,Calvigioni M,Vecchione A,Mrusek D,Bange G,Ghelardi E

    更新日期:2020-05-06 00:00:00

  • How community ecology can improve our understanding of cholera dynamics.

    abstract::Understanding the seasonal emergence and reemergence of cholera is challenging due to the complex dynamics of different protagonists. The abundance of Vibrio cholerae, the causative agent of cholera and a natural inhabitant of aquatic environments, fluctuates according to abiotic, and biotic factors. Among the biotic ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Constantin de Magny G,Hasan NA,Roche B

    更新日期:2014-04-02 00:00:00

  • Identification, Functional Characterization, and Regulon Prediction of the Zinc Uptake Regulator (zur) of Bacillus anthracis - An Insight Into the Zinc Homeostasis of the Pathogen.

    abstract::Zinc has an abounding occurrence in the prokaryotes and plays paramount roles including catalytic, structural, and regulatory. Zinc uptake regulator (Zur), a Fur family transcriptional regulator, is connoted in maintaining zinc homeostasis in the pathogenic bacteria by binding to zinc and regulating the genes involved...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Kandari D,Gopalani M,Gupta M,Joshi H,Bhatnagar S,Bhatnagar R

    更新日期:2019-01-11 00:00:00

  • Fecal Microbiota Transplant From Highly Feed Efficient Donors Affects Cecal Physiology and Microbiota in Low- and High-Feed Efficient Chickens.

    abstract::Fecal microbiota transplants (FMT) may be used to improve chicken's feed efficiency (FE) via modulation of the intestinal microbiota and microbe-host signaling. This study investigated the effect of the administration of FMT from highly feed efficient donors early in life on the jejunal and cecal microbiota, visceral ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Metzler-Zebeli BU,Siegerstetter SC,Magowan E,Lawlor PG,O Connell NE,Zebeli Q

    更新日期:2019-07-09 00:00:00

  • Resistome in Lake Bolonha, Brazilian Amazon: Identification of Genes Related to Resistance to Broad-Spectrum Antibiotics.

    abstract::Resistance to antibiotics is one of the most relevant public health concerns in the world. Aquatic environments play an important role because they are reservoirs for antibiotic resistance genes and antibiotic-resistant strains, contributing to the spread of resistance. The present study investigated the resistome in ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Alves J,Dias L,Mateus J,Marques J,Graças D,Ramos R,Seldin L,Henriques I,Silva A,Folador A

    更新日期:2020-02-04 00:00:00

  • Perspectives on Functional Red Mold Rice: Functional Ingredients, Production, and Application.

    abstract::Monacolin K (MK) is a secondary metabolite of the Monascus species that can inhibit cholesterol synthesis. Functional red mold rice (FRMR) is the fermentation product of Monascus spp., which is rich in MK. FRMR is usually employed to regulate serum cholesterol, especially for hypercholesterolemic patients who refuse s...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Yanli F,Xiang Y

    更新日期:2020-11-25 00:00:00

  • Extracellular Vesicles From the Helminth Fasciola hepatica Prevent DSS-Induced Acute Ulcerative Colitis in a T-Lymphocyte Independent Mode.

    abstract::The complexity of the pathogenesis of inflammatory bowel disease (ulcerative colitis and Crohn's disease) has led to the quest of empirically drug therapies, combining immunosuppressant agents, biological therapy and modulators of the microbiota. Helminth parasites have been proposed as an alternative treatment of the...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Roig J,Saiz ML,Galiano A,Trelis M,Cantalapiedra F,Monteagudo C,Giner E,Giner RM,Recio MC,Bernal D,Sánchez-Madrid F,Marcilla A

    更新日期:2018-05-23 00:00:00

  • Biodiversity of Photobacterium spp. Isolated From Meats.

    abstract::Photobacteria are common psychrophilic bacteria found in marine environments. Recently, several studies revealed high numbers of Photobacterium (P.) spp. on packaged fresh meat. Their occurrence appears relevant for the spoilage of meat, since species of the genus are already known as potent fish spoilage organisms. H...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Fuertes-Perez S,Hauschild P,Hilgarth M,Vogel RF

    更新日期:2019-10-18 00:00:00

  • Development of Multispecies Recombinant Nucleoprotein-Based Indirect ELISA for High-Throughput Screening of Crimean-Congo Hemorrhagic Fever Virus-Specific Antibodies.

    abstract::Crimean-Congo hemorrhagic fever (CCHF) is a re-emerging zoonotic viral disease prevalent in many parts of Asia, Europe, and Africa. The causative agent, Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV), is transmitted through hard ticks. Tick vectors especially belonging to the Hyalomma species serve as the res...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Shrivastava N,Shrivastava A,Ninawe SM,Sharma S,Kumar JS,Alam SI,Kanani A,Sharma SK,Dash PK

    更新日期:2019-08-23 00:00:00

  • Microbial Communities in Sediments From Four Mildly Acidic Ephemeral Salt Lakes in the Yilgarn Craton (Australia) - Terrestrial Analogs to Ancient Mars.

    abstract::The Yilgarn Craton in Australia has a large number of naturally occurring shallow ephemeral lakes underlain by a dendritic system of paleodrainage channels. Processes like evaporation, flooding, erosion, as well as inflow of saline, often acidic and ion-rich groundwater contribute to the (dynamic) nature of the lakes ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Aerts JW,van Spanning RJM,Flahaut J,Molenaar D,Bland PA,Genge MJ,Ehrenfreund P,Martins Z

    更新日期:2019-05-06 00:00:00

  • Chloroplast symbiosis in a marine ciliate: ecophysiology and the risks and rewards of hosting foreign organelles.

    abstract::Simultaneous use of both heterotrophic and autotrophic metabolism ("mixotrophy") is common among protists. Strombidium rassoulzadegani is a planktonic mixotrophic marine ciliate that saves chloroplasts from its algal food and obtains a nutritional subsidy via photosynthesis. Cultures from the northeast, northwest, and...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: McManus GB,Schoener DM,Haberlandt K

    更新日期:2012-09-04 00:00:00

  • CCp5A Protein from Toxoplasma gondii as a Serological Marker of Oocyst-driven Infections in Humans and Domestic Animals.

    abstract::Considering that the current immunoassays are not able to distinguish the infective forms that cause Toxoplasma gondii infection, the present study was carried out to evaluate the reactivity of two recombinant proteins (CCp5A and OWP1) from oocyst/sporozoite, in order to differentiate infections occurring by ingestion...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Santana SS,Gebrim LC,Carvalho FR,Barros HS,Barros PC,Pajuaba AC,Messina V,Possenti A,Cherchi S,Reiche EM,Navarro IT,Garcia JL,Pozio E,Mineo TW,Spano F,Mineo JR

    更新日期:2015-11-24 00:00:00

  • Global Distribution of Anaerobic Ammonia Oxidation (Anammox) Bacteria - Field Surveys in Wetland, Dryland, Groundwater Aquifer and Snow.

    abstract::The discovery of anaerobic ammonia oxidation (anammox) expanded our knowledge on the microbial nitrogen cycle. Previous studies report that anammox bacteria are distributed in a wide range of habitats and plays significant roles in the global nitrogen cycle. However, most studies focus only on individual ecosystems or...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Wang Y,Xu L,Wang S,Ye F,Zhu G

    更新日期:2019-11-12 00:00:00

  • Laccases: Production, Expression Regulation, and Applications in Pharmaceutical Biodegradation.

    abstract::Laccases are a family of copper-containing oxidases with important applications in bioremediation and other various industrial and biotechnological areas. There have been over two dozen reviews on laccases since 2010 covering various aspects of this group of versatile enzymes, from their occurrence, biochemical proper...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审


    authors: Yang J,Li W,Ng TB,Deng X,Lin J,Ye X

    更新日期:2017-05-16 00:00:00

  • Physical-Chemical Properties of Biogenic Selenium Nanostructures Produced by Stenotrophomonas maltophilia SeITE02 and Ochrobactrum sp. MPV1.

    abstract::Stenotrophomonas maltophilia SeITE02 and Ochrobactrum sp. MPV1 were isolated from the rhizosphere soil of the selenium-hyperaccumulator legume Astragalus bisulcatus and waste material from a dumping site for roasted pyrites, respectively. Here, these bacterial strains were studied as cell factories to generate seleniu...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Piacenza E,Presentato A,Ambrosi E,Speghini A,Turner RJ,Vallini G,Lampis S

    更新日期:2018-12-19 00:00:00

  • Growth Phase, Oxygen, Temperature, and Starvation Affect the Development of Viable but Non-culturable State of Vibrio cholerae.

    abstract::Vibrio cholerae can enter into a viable but non-culturable (VBNC) state in order to survive in unfavorable environments. In this study, we studied the roles of five physicochemical and microbiological factors or states, namely, different strains, growth phases, oxygen, temperature, and starvation, on the development o...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Wu B,Liang W,Kan B

    更新日期:2016-03-30 00:00:00

  • Algae-based oral recombinant vaccines.

    abstract::Recombinant subunit vaccines are some of the safest and most effective vaccines available, but their high cost and the requirement of advanced medical infrastructure for administration make them impractical for many developing world diseases. Plant-based vaccines have shifted that paradigm by paving the way for recomb...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审


    authors: Specht EA,Mayfield SP

    更新日期:2014-02-17 00:00:00

  • Biomethanation of Syngas Using Anaerobic Sludge: Shift in the Catabolic Routes with the CO Partial Pressure Increase.

    abstract::Syngas generated by thermal gasification of biomass or coal can be steam reformed and purified into methane, which could be used locally for energy needs, or re-injected in the natural gas grid. As an alternative to chemical catalysis, the main components of the syngas (CO, CO2, and H2) can be used as substrates by a ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Sancho Navarro S,Cimpoia R,Bruant G,Guiot SR

    更新日期:2016-08-03 00:00:00

  • Different metabolic features of Bacteroides fragilis growing in the presence of glucose and exopolysaccharides of bifidobacteria.

    abstract::Bacteroides is among the most abundant microorganism inhabiting the human intestine. They are saccharolytic bacteria able to use dietary or host-derived glycans as energy sources. Some Bacteroides fragilis strains contribute to the maturation of the immune system but it is also an opportunistic pathogen. The intestine...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Rios-Covian D,Sánchez B,Salazar N,Martínez N,Redruello B,Gueimonde M,de Los Reyes-Gavilán CG

    更新日期:2015-08-18 00:00:00

  • Prioritized Expression of BDH2 under Bulk Translational Repression and Its Contribution to Tolerance to Severe Vanillin Stress in Saccharomyces cerevisiae.

    abstract::Vanillin is a potent fermentation inhibitor derived from the lignocellulosic biomass in biofuel production, and high concentrations of vanillin result in the pronounced repression of bulk translation in Saccharomyces cerevisiae. Studies on genes that are efficiently translated even in the presence of high concentratio...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Ishida Y,Nguyen TT,Kitajima S,Izawa S

    更新日期:2016-07-06 00:00:00

  • oriC-encoded instructions for the initiation of bacterial chromosome replication.

    abstract::Replication of the bacterial chromosome initiates at a single origin of replication that is called oriC. This occurs via the concerted action of numerous proteins, including DnaA, which acts as an initiator. The origin sequences vary across species, but all bacterial oriCs contain the information necessary to guide as...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审


    authors: Wolański M,Donczew R,Zawilak-Pawlik A,Zakrzewska-Czerwińska J

    更新日期:2015-01-06 00:00:00

  • Use of Rhizobacteria and Mycorrhizae Consortium in the Open Field as a Strategy for Improving Crop Nutrition, Productivity and Soil Fertility.

    abstract::Plant growth promoting rhizobacteria (PGPR) and arbuscular mycorrhizal fungi (AMF) are known for their beneficial effects. In recent years, more attention has been paid to their use as biofertilizers to reduce the use of chemical fertilizers causing significant damage to the environment. To have high plant yields, bio...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Raklami A,Bechtaoui N,Tahiri AI,Anli M,Meddich A,Oufdou K

    更新日期:2019-05-21 00:00:00

  • Diatom-Bacteria Interactions Modulate the Composition and Productivity of Benthic Diatom Biofilms.

    abstract::Benthic diatoms are dominant primary producers in intertidal mudflats and constitute a major source of organic carbon to consumers and decomposers residing within these ecosystems. They typically form biofilms whose species richness, community composition and productivity can vary in response to environmental drivers ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Koedooder C,Stock W,Willems A,Mangelinckx S,De Troch M,Vyverman W,Sabbe K

    更新日期:2019-06-05 00:00:00

  • Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut.

    abstract::With the increasing amount of evidence linking certain disorders of the human body to a disturbed gut microbiota, there is a growing interest for compounds that positively influence its composition and activity through diet. Besides the consumption of probiotics to stimulate favorable bacterial communities in the huma...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审


    authors: Rivière A,Selak M,Lantin D,Leroy F,De Vuyst L

    更新日期:2016-06-28 00:00:00