当前位置： SCI文献检索 > EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING期刊下所有文献 > Incremental value of amyloid-PET versus CSF in the diagnosis of Alzheimer's disease.

Incremental value of amyloid-PET versus CSF in the diagnosis of Alzheimer's disease.

Abstract：

PURPOSE:To compare the incremental diagnostic value of amyloid-PET and CSF (Aβ42, tau, and phospho-tau) in AD diagnosis in patients with mild cognitive impairment (MCI) or mild dementia, in order to improve the definition of diagnostic algorithm. METHODS:Two independent dementia experts provided etiological diagnosis and relative diagnostic confidence in 71 patients on 3 rounds, based on (1) clinical, neuropsychological, and structural MRI information alone; (2) adding one biomarker (CSF amyloid and tau levels or amyloid-PET with a balanced randomized design); and (3) adding the other biomarker. RESULTS:Among patients with a pre-biomarker diagnosis of AD, negative PET induced significantly more diagnostic changes than amyloid-negative CSF at both rounds 2 (CSF 67%, PET 100%, P = 0.028) and 3 (CSF 0%; PET 78%, P < 0.001); PET induced a diagnostic confidence increase significantly higher than CSF on both rounds 2 and 3. CONCLUSIONS:Amyloid-PET should be prioritized over CSF biomarkers in the diagnostic workup of patients investigated for suspected AD, as it provides greater changes in diagnosis and diagnostic confidence. TRIAL REGISTRATION:EudraCT no.: 2014-005389-31.

journal_name

Eur J Nucl Med Mol Imaging

journal_title

European journal of nuclear medicine and molecular imaging

authors

Ramusino MC,Garibotto V,Bacchin R,Altomare D,Dodich A,Assal F,Mendes A,Costa A,Tinazzi M,Morbelli SD,Bauckneht M,Picco A,Dottorini ME,Tranfaglia C,Farotti L,Salvadori N,Moretti D,Savelli G,Tarallo A,Nobili F,Parap

doi

10.1007/s00259-019-04466-6

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

270-280

issue

2

eissn

1619-7070

issn

1619-7089

pii

10.1007/s00259-019-04466-6

journal_volume

47

pub_type

杂志文章

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